Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease

Bryzgalov, L. O.; Korbolina, Elena E.; Merkulova, T. I.

doi:10.3390/ijms24097955

Cited by 3 publications

(2 citation statements)

References 124 publications

(159 reference statements)

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“…According to several authors, RNA interference mediated by microRNAs can initiate neurovascular events leading to Alzheimer’s-type neurodegeneration [ 90 , 91 , 92 , 93 ]. This provides a strong theoretical basis for the development of new directions in targeted genetic therapy for neurodegenerative diseases [ 94 , 95 , 96 , 97 ].…”

Section: The Role Of Micrornas In Signaling Pathways Of Alzheimer’s-t...mentioning

confidence: 99%

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Tregub,

Ibrahimli,

Averchuk

et al. 2023

IJMS

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In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.

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Section: The Role Of Micrornas In Signaling Pathways Of Alzheimer’s-t...mentioning

confidence: 99%

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Tregub,

Ibrahimli,

Averchuk

et al. 2023

IJMS

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“…‘Genetic factors that increase or decrease susceptibility to such exogenous influences warrant further study’ (Ruebel & Latham, 2020). An initial example of an approach to explore the genetic predisposition to epigenetic changes was carried out for Alzheimer's disease (Bryzgalov, et al., 2023), where research is examining the involvement of interacting epigenetic and epitranscriptomic effects (Moore, 2022).…”

Section: Introductionmentioning

confidence: 99%

Evolutionary feedback from the environment shapes mechanisms that generate genome variation

Caporale

2024

The Journal of Physiology

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Darwin recognized that ‘a grand and almost untrodden field of inquiry will be opened, on the causes and laws of variation.’ However, because the Modern Synthesis assumes that the intrinsic probability of any individual mutation is unrelated to that mutation's potential adaptive value, attention has been focused on selection rather than on the intrinsic generation of variation. Yet many examples illustrate that the term ‘random’ mutation, as widely understood, is inaccurate. The probabilities of distinct classes of variation are neither evenly distributed across a genome nor invariant over time, nor unrelated to their potential adaptive value. Because selection acts upon variation, multiple biochemical mechanisms can and have evolved that increase the relative probability of adaptive mutations. In effect, the generation of heritable variation is in a feedback loop with selection, such that those mechanisms that tend to generate variants that survive recurring challenges in the environment would be captured by this survival and thus inherited and accumulated within lineages of genomes. Moreover, because genome variation is affected by a wide range of biochemical processes, genome variation can be regulated. Biochemical mechanisms that sense stress, from lack of nutrients to DNA damage, can increase the probability of specific classes of variation. A deeper understanding of evolution involves attention to the evolution of, and environmental influences upon, the intrinsic variation generated in gametes, in other words upon the biochemical mechanisms that generate variation across generations. These concepts have profound implications for the types of questions that can and should be asked, as omics databases become more comprehensive, detection methods more sensitive, and computation and experimental analyses even more high throughput and thus capable of revealing the intrinsic generation of variation in individual gametes. These concepts also have profound implications for evolutionary theory, which, upon reflection it will be argued, predicts that selection would increase the probability of generating adaptive mutations, in other words, predicts that the ability to evolve itself evolves. image

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Identification of biomarkers and molecular mechanisms implicated in genetic variations underlying Alzheimer's disease pathogenesis

Nguyen,

Vu,

Kim

2024

Aspects of Molecular Medicine

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Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease

Cited by 3 publications

References 124 publications

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Evolutionary feedback from the environment shapes mechanisms that generate genome variation

Identification of biomarkers and molecular mechanisms implicated in genetic variations underlying Alzheimer's disease pathogenesis

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