Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis

Shahriyari, Elham; Vahedi, Leila; Roshanipour, Nasrin; Jafarabadi, Mohammad Asghari; Khamaneh, Amin; Laleh, Maryam Ghaffari

doi:10.1186/s12950-019-0230-2

Cited by 11 publications

(6 citation statements)

References 61 publications

(70 reference statements)

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“…Ni et al 32 presented an association between IL-10 1082 G allele and risk of developing gastric cancer. Although other meta-analyses have shown the association between IL-10 polymorphisms and other diseases 16 , 31 – 35 , the present meta-analysis of five case–control studies did not indicate IL-10 SNPs as a risk factor or protective factor for the progression of leishmaniasis.…”

Section: Discussioncontrasting

confidence: 99%

Association between interleukin 10 (IL-10) polymorphisms and leishmaniasis progression: a systematic review and meta-analysis

Silva

Vasconcelos

Tavares

et al. 2022

Sci Rep

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Interleukin 10 (IL-10) is associated with the progression of leishmaniasis because it inhibits the leishmanicidal action of macrophages and the production of mediators such as IFN-γ and nitric oxide. Studies have shown that specific polymorphisms are associated with the regulatory role of IL-10 and the development of more relevant clinical forms of leishamaniasis. We performed a systematic review and meta-analysis to determine whether single nucleotide polymorphisms (SNPs) of IL-10 influence the progression of leishmaniasis. The selected articles were read in full and only those consistent with the eligibility criteria were included in our study. Seven studies were eligible according to the inclusion criteria and were included in the present systematic review, but only five were subjected to statistical analysis. The pooled odds ratios showed no significant association between the rs1800871 SNP and the progression of leishmaniasis in all genotype models, including the dominant, recessive, homozygote, heterozygote, and allelic models. Regarding the association between rs1800896 SNP and the progression of leishmaniasis, the pooled odds ratios showed no association under all genotype models. Hence, IL-10 SNPs did not show significant association and were not considered a risk factor for the progression of leishmaniasis.

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Section: Discussioncontrasting

confidence: 99%

Association between interleukin 10 (IL-10) polymorphisms and leishmaniasis progression: a systematic review and meta-analysis

Silva

Vasconcelos

Tavares

et al. 2022

Sci Rep

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“…Previous studies have shown a significant relationship between IL-10 ─ 819 C/T SNP and several diseases, including Alzheimer's disease, lung cancer, and Behcet's disease [13][14][15][16]. We demonstrated that the T allele of the IL-10 ─ 819 gene is associated with higher risks of periodontitis.…”

Section: Discussionmentioning

confidence: 53%

“…At the same time, it suppresses the innate response and thus, might contribute to bacterial persistence and the following chronic infection in the region [12]. Two detected single nucleotide polymorphisms (SNPs) in the promoter region of the IL-10 gene, including at positions − 819 and − 592, are reported to be associated with several diseases [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Saremi

Shafizadeh

Ghaffari

et al. 2022

Egypt J Med Hum Genet

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Background Chronic periodontitis (CP) is a prevalent infectious disease caused by an interplay between pathogens and immune responses. Gene polymorphisms are among the factors that affect susceptibility to CP. This study aimed to assess the association between CP and single nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10), interleukin 1ß (IL-1ß), and tumor necrosis factor-α (TNF-α) genes. Methods A total of 87 patients with CP and 89 healthy controls were included in this study. Venous blood samples were obtained, and DNA was extracted and purified. Segments containing the relevant genes were amplified by polymerase chain reaction (PCR). Electrophoresis was performed after restriction fragment length polymorphism (RFLP) to determine genotype and allele frequencies. Results The CP group showed significantly different allele and genotype frequencies for three out of five SNPs: IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, and IL-1ß + 3954 C/T (p < 0.05). Additionally, the frequency of the TNF-α ─ 857 AA genotype was significantly lower in patients compared with controls (p = 0.034); however, no significant differences were found in allele frequencies (p > 0.05). Logistic regression analysis revealed that carriers of IL-10 ─ 592 A allele and IL-1ß + 3954 T allele are at higher risk of CP (p < 0.001). Allele and genotype frequencies for TNF-α ─ 308 G/A did not differ significantly between patients and controls (p > 0.05). Conclusions This study showed specific genotypes of IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, IL-1ß + 3954 C/T, and TNF-α ─ 857 G/A SNPs may be associated with an increased risk of CP development.

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“…In 2019, two latest meta-analyses were published by Shahriyari et al and Lee and Song. The two publications had collected all current case-control studies and made an updated conclusion on the association between IL-10 polymorphisms and BD risk [39,40].…”

Section: Discussionmentioning

confidence: 99%

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

Huang

et al. 2020

Journal of Immunology Research

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Epidemiological studies have demonstrated that interleukin-10 (IL-10) polymorphisms may be associated with the development of Behcet’s disease (BD). However, the published results were inconsistent. Therefore, this meta-analysis was conducted to derive a more precise relationship between IL-10 polymorphisms and BD susceptibility. Online databases (PubMed, Embase, Science Citation Index (SCI), CNKI, and WanFang) were searched to identify eligible studies. Odds ratio (OR) and a 95% confidence interval (CI) were applied to assess the relationship strength between IL-10 -1082A>G (rs1800896), -819T>C (rs1800871), and -592A>C (rs1800872) polymorphisms and BD susceptibility. Publication bias, sensitivity, and cumulative analyses were conducted to measure the robustness of our findings. Finally, fifteen articles (36 independent case-control studies) involving 5,971 patients and 8,913 controls were included. Overall, significant associations between -819T>C polymorphisms and BD risk were observed in the total population (C vs. T: OR=0.72, 95%CI=0.67‐0.77, P<0.01, I2=36.6%; TC vs. TT: OR=0.73, 95%CI=0.66‐0.80, P<0.01, I2=23.0%; CC vs. TT: OR=0.52, 95%CI=0.39‐0.70, P<0.01, I2=53.7%; TC+CC vs. TT: OR=0.67, 95%CI=0.61‐0.71, P<0.01, I2=22.1%; and CC vs. TT+TC: OR=0.66, 95%CI=0.53‐0.82, P<0.01, I2=57.8%). Moreover, the IL-10 -592 A>C polymorphism and the ACC haplotype exhibited a significant, protective effect against BD susceptibility. In summary, our meta-analysis suggested that IL-10 gene polymorphisms may play a salient role for BD development.

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Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis

Cited by 11 publications

References 61 publications

Association between interleukin 10 (IL-10) polymorphisms and leishmaniasis progression: a systematic review and meta-analysis

Association between interleukin 10 (IL-10) polymorphisms and leishmaniasis progression: a systematic review and meta-analysis

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Association between Interleukin-10 Gene Polymorphisms and Behcet’s Disease Susceptibility: Evidence from a Meta-Analysis

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