Exploring the association between parental psychiatric disease and childhood atopic dermatitis: a matched case–control study

Abstract

Background Maternal prenatal psychiatric disease has been identified as a possible risk factor for atopic dermatitis development in her children. We quantified the associations between maternal and paternal psychiatric disease and the development of atopic dermatitis in their offspring using nationwide registries.Methods All children in Denmark born between 1 January 1996 and 31 December 2011 who developed atopic dermatitis prior to their fifth birthday were identified and individually matched 1:10 with controls from the general population and with children receiving care in a similar ambulatory/hospital setting. Conditional logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals.Results A total of 8602 children with atopic dermatitis were matched with controls. Rates of parental psychiatric care were similar in the atopic dermatitis and control groups. When compared to the general population, weak associations were found between childhood atopic dermatitis and maternal history of depression [OR 1.18 (95% confidence interval:

Does Prenatal Anxiety or Depression Symptoms Associate With Asthma or Atopic Diseases Throughout the Offspring's Childhood? An Updated Systematic Review and Meta-analysis

“…Of these, 273 articles were left for full-text screening and 264 were excluded because of not accessible (n=10), study aim/design (n=54), population (n=100), outcome (n=28), intervention (n=63), animal (n=9). Since no additional records identi ed through other sources, giving a total of 9 observational studies entered our nal model [10,12,13,[18][19][20][21][22][23].…”

“…Characteristics of the included studies Table 1 presents the included studies [10,12,13,[18][19][20][21][22][23]. There were 4 prospective cohort studies [7,[18][19][20], 4 retrospective cohort studies [12,13,21,22] [11,13,21,22] and 1 case-control study [23]. The majority of included studies came from Europe, and the rest of them were from America.…”

“…The included studies investigated based on different exposure including depression, anxiety, depression or anxiety, mental health service use, prenatal postpartum distress, and negative life events. Studies were grouped into the categories according to their outcomes which had 5 asthma [10,12,13,18,21], 3 AD [19,20,23], and 1 asthma and AD [22]. To ensure the reliability and quality control of this metaanalysis, we scored each of the included studies by using NOS criteria, studies with more than ve stars can be included in the research.…”

“…To ensure the reliability and quality control of this metaanalysis, we scored each of the included studies by using NOS criteria, studies with more than ve stars can be included in the research. After evaluation, there were 6 studies scored 9 [10,12,18,20,22,23], and 3 studies scored 8 [13,19,21] (Supplementary Table 1a). The outcome of Letourneau et al, 2017 was measured when the infants were only 18-months old which contribute to an insu cient follow-up period for outcome occurrence [19].…”

“…The effect of prenatal depression on childhood AD Four studies (eight databases) [19,20,22,23] could be included for the meta-analysis of prenatal depression on childhood AD. The result indicated that there has no statistically signi cant between the control group and treatment group, which means prenatal depression may not bring in uences on childhood AD (ES=1.211, 95%CI: 0.982-1.494, P=0.073; I 2 =78.5%, P heterogeneity <0.001) ( Figure 2B and Table 2b).…”