The Role of Environmental Exposures in Atopic Dermatitis

Narla, Shanthi; Silverberg, Jonathan I.

doi:10.1007/s11882-020-00971-z

Cited by 52 publications

(45 citation statements)

References 118 publications

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“…The late colonization of the adult gut resulted in a different gut microbiota composition that may by itself affect the immunological response and severity of disease. The effect of delayed colonization on oxazolone-induced dermatitis was not detected in mice colonized upon birth, and in utero exposures including maternal stress, gestational diabetes, antibiotic treatment and other environmental factors that can affect the maternal microbiota and which has been associated with a high risk of developing childhood eczema (9), may as such only play a long-term role for immune maturation and atopic disease if they also disturb the intestinal colonization of the infant gut following birth. Thus, we find that the colonization pattern of the very first colonizers is crucial for the development of atopic dermatitis.…”

Section: Discussionmentioning

confidence: 95%

“…the atopic march. The increasing prevalence of allergic diseases has long been explained by a westernized lifestyle with excessive hygiene, vaccination and widespread use of antibiotics, as well as drastic changes in dietary habits; factors that all modulate the establishment of the early gut microbiome (8,9). The gut microbiome of children with atopic dermatitis is different from healthy age-matched children (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis

et al. 2021

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Epidemiological studies have long reported that perturbations of the childhood microbiome increase the risk of developing allergies, but a causal relationship with atopic dermatitis remains unclear. Here we colonized germ-free mice at birth or at one or eight week-of-age to investigate the role of prenatal and early postnatal microbial exposure on development of oxozolone-induced dermatitis later in life. We demonstrate that only one week delayed microbial colonization increased IgE levels and the total histological score of the inflamed ear compared to mice colonized throughout life. In parallel, several pro-inflammatory cytokines and chemokines were upregulated in the ear tissue demonstrating an enhanced immunological response following delayed postnatal colonization of the gut. In contrast, sensitivity to oxazolone-induced dermatitis was unaffected by the presence of a maternal microbiota during gestation. Mice colonized at eight week-of-age failed to colonize Rikenellaceae, a group of bacteria previously associated with a high-responding phenotype, and did not develop an immunological response to the same extent as the early colonized mice despite pronounced histopathological manifestations. The study provides proof-of-principle that the first intestinal colonizers of mice pups are crucial for the development of oxazolone-induced dermatitis later in life, and that the status of the maternal microbiota during pregnancy has no influence on the offspring’s allergic immune response. This highlights an important window of opportunity following birth for microbiota-mediated interventions to prevent atopic responses later in life. How long such a window is open may vary between mice and humans considering species differences in the ontogeny of the immune system.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis

et al. 2021

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“…While the heritability of AD has been confirmed in human and canine studies, and the strong breed predisposition seen in atopic dogs further supports an important role for genetic factors, the search for inherited traits associated with AD continues in both the veterinary and human medical arenas, with no consistent genetic factors yet being identified. 2,5,7,8 A strong tendency to Th2 lymphocytedominated immune responses, driving allergenspecific IgE production, has long been considered a hallmark of AD, and this response is known to be inherited. However, the specifics of this heritability are unknown, and it is recognised that a subset of people and dogs with AD do not appear to have a propensity to produce allergenspecific IgE at any stage during the course of the disease.…”

Section: What Causes Atopic Dermatitis?mentioning

confidence: 99%

“…lack of siblings, antibiotic use) and protective factors (rural environments, access to farmland/ farm animals, regular dog contact, noncommercial diets) have been identified for AD in children and dogs. [7][8][9] It is theorised that such environmental factors may result in crucial changes to skin microbiota and the skin immune system, either contributing to or moderating disease progression. However, the mechanisms behind these effects remain unclear.…”

Section: What You Need To Knowmentioning

confidence: 99%

“…However, the mechanisms behind these effects remain unclear. 2,7 Collectively, the genetic and environmental factors involved in the pathogenesis of AD result in skin barrier dysfunction, immune system dysregulation and skin microbiome alterations (dysbiosis) in affected individuals. However, it is currently unclear which of these changes is most critical to disease development and whether this may vary between individuals.…”

Section: What You Need To Knowmentioning

confidence: 99%

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Canine atopic dermatitis: a common, chronic and challenging dermatosis

Vogelnest¹

2021

Veterinary Record

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Nanotopology‐Enabled On‐Site Pathogen Detection for Managing Atopic Dermatitis

Kim,

Song,

Kim

et al. 2024

Adv Healthcare Materials

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Atopic dermatitis (AD), a prevalent skin condition often complicated by microbial infection, poses a significant challenge in identifying the responsible pathogen for its effective management. However, a reliable, safe tool for pinpointing the source of these infections remains elusive. In this study, we propose a novel on‐site pathogen detection that combines chemically functionalized nanotopology with genetic analysis to capture and analyze pathogens closely associated with severe atopic dermatitis. The chemically functionalized nanotopology features a 3D hierarchical nanopillar array (HNA) with a functional polymer coating, tailored to isolate target pathogens from infected skin. This innovative nanotopology demonstrates superior pathogenic capture efficiency, favorable entrapment patterns, and non‐cytotoxicity. We utilize an HNA‐assembled stick to directly retrieve bacteria from infected skin samples, followed by extraction‐free quantitative loop‐mediated isothermal amplification (direct qLAMP) for validation. To mimic human skin conditions, we employ porcine skin, successfully capturing Staphylococcus aureus, a common bacterium exacerbating AD cases. Our on‐site detection method exhibits an impressive detection limit of 10^3 cells/mL. The HNA‐assembled stick represents a promising tool for on‐site detection of bacteria associated with atopic dermatitis. This innovative approach enables to deepen our understanding of AD pathogenesis and open avenues for more effective management strategies for chronic skin condition.This article is protected by copyright. All rights reserved

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The Role of Environmental Exposures in Atopic Dermatitis

Cited by 52 publications

References 118 publications

Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis

Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis

Canine atopic dermatitis: a common, chronic and challenging dermatosis

Nanotopology‐Enabled On‐Site Pathogen Detection for Managing Atopic Dermatitis

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