Exploring the applications of hyaluronic acid‐based nanoparticles for diagnosis and treatment of bacterial infections

Mohammed, Mahir; Devnarain, Nikita; Elhassan, Eman; Govender, Thirumala

doi:10.1002/wnan.1799

Cited by 30 publications

(27 citation statements)

References 117 publications

(265 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, HA-based colloidal PECs have not been widely studied for antibiotic delivery. From the bacterial targeting effect of HA suggested by Simonson et al after their studies on HA/PLL colloidal PECs for treating E. coli and S. aureus [36] (Section 4.1) and several recent works which reveal remarkable interest in HA-based nanoformulations for infection treatment, [194,195] antimicrobial applications of HA-based colloidal PECs should be considered for more serious investigation, especially in the current era where more powerful therapeutic platforms are needed to cope with increasing antibiotic resistance.…”

Section: Current Limitations and Future Perspectivesmentioning

confidence: 99%

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Cerf

2022

Small

View full text Add to dashboard Cite

nanocomplexes, [8,9] nanocomposites, [10,11] nanoassemblies [12] and coacervates. [13,14] Such colloidal systems, especially when prepared from biopolymers, have been extensively investigated due to their promising properties for numerous applications in biomedical fields. [1] Their merits come from the combination of three aspects: nanomedicine, biomaterials, and green chemistry. With the emergence of nanomedicine, the use of nanocarriers can offer tremendous advantages in drug encapsulation and delivery, namely enhancing the chemical stability of drugs and improving drug solubility and bioavailability. [15] Due to their small size and the possibility of surface modification with biological ligands or molecular imprinting, nanocarriers can easily cross biological barriers, which have limited pore sizes (fenestrations) under 1 micron in most cases, then target and enter the tissues or cells of interest. [16,17] Due to these aspects and the possibility of controlling drug distribution and release through particle engineering, nanocarriers can thus reduce systemic side effects and enhance the therapeutic efficacy of drugs. [15] Nanosystems can also offer unique advantages for biomedical imaging with their ability of sensing, image enhancement, and incorporating concomitantly therapeutic agents for theranostics, that is, simultaneous therapeutic and diagnostic applications. [18][19][20] When constructed from biomaterials, especially naturally occurring polysaccharides or proteins, PECs can become significantly biocompatible and biodegradable with much less immunogenicity and toxicity. [21] Besides such biorelevant aspects, the elaboration of biopolymerbased PECs is also in accordance with green chemistry principles since their preparation process usually requires only gentle mixing of polyelectrolyte solutions at room temperature, which is a simple and rapid procedure without the need for chemical agents, surfactants, organic solvents or high mechanical or thermal energy. [15] Beyond the above-mentioned basic advantages, the potential of colloidal PEC systems is increased by the inherent biological and chemical properties of individual constituent polymers. Hyaluronic acid (HA), also called hyaluronan to generally mention both its acid and salt forms, has been one of the most common polyanions among several biopolymers reported so far for the elaboration of colloidal PECs. The significant attention dedicated to HA in biomedical fields is associated with its unique advantages, stemming from not only its outstanding biocompatibility but also interesting biological activities. [22] Hyaluronic acid (HA) is a naturally occurring polysaccharide which has been extensively exploited in biomedical fields owing to its outstanding biocompatibility. Self-assembly of HA and polycations through electrostatic interactions can generate colloidal polyelectrolyte complexes (PECs), which can offer a wide range of applications while being relatively simple to prepare with rapid and "green" processes. The advantages of colloidal HA-base...

show abstract

Section: Current Limitations and Future Perspectivesmentioning

confidence: 99%

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Cerf

2022

Small

View full text Add to dashboard Cite

show abstract

“…[58][59][60] These functionalized hydrogels consist of HA and gelatin, which are key ECM components of many tissues and organs. [61][62][63] To generate HAMA bioinks in this study, the methacrylate groups were modified onto the backbone of the HA through the reaction of MA with hydroxyl groups of HA. Successful synthesis of HAMA was confirmed via 1 H NMR spectroscopy which demonstrated the peaks at 1.9 ppm and 5.6-6.1 ppm, representing the N-acetyl glucosamine of HA and the methacrylate protons, respectively (Figure 2A-i,ii).…”

Section: Resultsmentioning

confidence: 99%

Extrusion‐Based 3D Bioprinting of Adhesive Tissue Engineering Scaffolds Using Hybrid Functionalized Hydrogel Bioinks

et al. 2023

View full text Add to dashboard Cite

Adhesive tissue engineering scaffolds (ATESs) have emerged as an innovative alternative means, replacing sutures and bioglues, to secure the implants onto target tissues. Relying on their intrinsic tissue adhesion characteristics, ATES systems enable minimally invasive delivery of various scaffolds. This study investigates development of the first class of 3D bioprinted ATES constructs using functionalized hydrogel bioinks. Two ATES delivery strategies, in situ printing onto the adherend versus printing and then transferring to the target surface, are tested using two bioprinting methods, embedded versus air printing. Dopamine-modified methacrylated hyaluronic acid (HAMA-Dopa) and gelatin methacrylate (GelMA) are used as the main bioink components, enabling fabrication of scaffolds with enhanced adhesion and crosslinking properties. Results demonstrate that dopamine modification improved adhesive properties of the HAMA-Dopa/GelMA constructs under various loading conditions, while maintaining their structural fidelity, stability, mechanical properties, and biocompatibility. While directly printing onto the adherend yields superior adhesive strength, embedded printing followed by transfer to the target tissue demonstrates greater potential for translational applications. Together, these results demonstrate the potential of bioprinted ATESs as off-the-shelf medical devices for diverse biomedical applications.

show abstract

“…Physical crosslinking strategy is based on its anionic and hydrophilic nature ( Figure a). [ 64 ] Based on anionic nature, HA can form ion complex nanoparticles through polyelectrolyte complexation when blended with cationic polymers. One of the most widely used cationic polymers for nanogel preparation is chitosan (CS).…”

Section: Hydrogel Formsmentioning

confidence: 99%

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Luo,

Wang,

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, and highly designable capacity, HA hydrogels have been an emerging biomaterial, showing tailoring performance in terms of chemical modifications and hydrogel forms. Various preparation technologies have been developed for the fabrication of the tailoring HA hydrogels with unique structures and functions. They have been utilized in diverse biomedical applications like drug delivery and tissue engineering scaffolds. Herein, this review comprehensively summarizes the HA derivatives with different molecule weights and functional modifications. Then the various fabrication methods to obtain tailoring hydrogels in the forms of nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, and scaffold are reviewed as well. The emphasis is focused on the shining biomedical applications of these tailoring HA hydrogels in anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. The potentials and prospects are subsequently given to inspire further investigation, aiming at accelerating product translation from research to clinic.

show abstract

Exploring the applications of hyaluronic acid‐based nanoparticles for diagnosis and treatment of bacterial infections

Cited by 30 publications

References 117 publications

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Colloidal Polyelectrolyte Complexes from Hyaluronic Acid: Preparation and Biomedical Applications

Extrusion‐Based 3D Bioprinting of Adhesive Tissue Engineering Scaffolds Using Hybrid Functionalized Hydrogel Bioinks

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Contact Info

Product

Resources

About