Exploring the anti-breast cancer potential of flavonoid analogs

Thakor, V. M.; Poddar, Mayur; Dey, Sumit; Manjula, S; Madhunapantula, SubbaRao V.; Pawara, Rahul; Patel, Harun; Noolvi, Malleshappa N.

doi:10.1039/c6ra14428d

Cited by 15 publications

(4 citation statements)

References 35 publications

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“…The developed NPs have shown effective anticancer activity by 77 µg as ED 50 whereas the Gloriosasuperba leaf extract showed the ED 50 value at 80 µg. The studies thus demonstrated NPs to be environment friendly to deliver the potential active drugs against triple negative breast cancer (33).…”

Section: Gloriosasuperba Mediated Nanoparticlesmentioning

confidence: 91%

Potent Nano Carriers for Targeting Breast Cancer

Sangam¹,

Shekar²

2020

IJAR

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Breast cancer (BC) is the most common cancer in female population. Triple-negative breast cancer (TNBC) is the subtype of breast cancer in which the three major receptors are absent. TNBC has very aggressive phenotype and high spreading rate/metastasis which often results in resistance to chemotherapy. Nano-medicines offer various promising approaches to BC and TNBC therapy because of its unique characteristics viz.nanometric size, high drug payload, targeting capabilities and capability to accommodate multiple therapeutic moieties.This review focuses on the conventional therapies, novel approaches and recent treatment strategies available for the therapeutic benefits to the patients. The role of cancer stem cell in the recurrence of BC and TNBC has also been highlighted. Moreover, the application of nanomedicines for the treatment of BC/TNBC and different molecular targets available for further exploration have also been discussed.Nanomedicines offers a right platform to develop multifaceted treatment strategies to control the spread and recurrence of BC/TNBC. Researchers explored multiple pathways that can play a major role in controlling the progression of TNBC. Several chemotherapeutic agents were delivered using these nanocarriers with outstanding responses. Numerous targets were also reported that could stop/alter the specific pathway or receptor interaction.

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Section: Gloriosasuperba Mediated Nanoparticlesmentioning

confidence: 91%

Potent Nano Carriers for Targeting Breast Cancer

Sangam¹,

Shekar²

2020

IJAR

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“…Several natural products have proved to be potent sources of anti-cancer drugs, as cancer is one of the leading causes of death worldwide ( Butler, 2004 ; Ghosh et al, 2014 ). As a result of the continuous exploration of traditional Chinese medicine, medicinal plants have emerged as a unique treatment strategy for cancer, primarily due to their accessibility, low toxicity, and well tolerated nature ( Takebe et al, 2011 ; Thakor et al, 2016 ). Natural bioactive compounds, especially flavonoids, have a significant impact on the treatment of cancer.…”

Section: Therapeutic Effects Of Taxifolinmentioning

confidence: 99%

An insight into novel therapeutic potentials of taxifolin

et al. 2023

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Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees, which is often found in foods such as onions and olive oil, and is also used in commercial preparations, and has attracted the interest of nutritionists and medicinal chemists due to its broad range of health-promoting effects. It is a powerful antioxidant with excellent antioxidant, anti-inflammatory, anti-microbial and other pharmacological activities. This review focuses on the breakthroughs in taxifolin for the treatment of diseases from 2019 to 2022 according to various systems of the human body, such as the nervous system, immune system, and digestive system, and on the basis of this review, we summarize the problems of current research and try to suggest solutions and future research directions.

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“…Briefly, the cells were pre-treated with 2.5 μg/ml of methanol extract for 20 h. The media was removed and washed once with PBS and incubated with DCFH-DA solution (20 μM/well) for 30 min. The cells were then treated with 1000 μM of H 2 O 2 for 6 h. Finally, at the end of the 6 th h, the fluorescence intensity (FI) of DCF was measured in a microplate reader with an excitation wavelength of 485 nm and an emission wavelength of 535 nm [17].…”

Section: Ros Measurement By Dcfh-damentioning

confidence: 99%

Neuroprotective and Cognitive Enhancing Effect of Methanolic Morus Alba Leaf Fraction in U87mg Cell Lines and Experimental Rat Model

Raj

Dey

Madhunapantula

et al. 2019

Asian J Pharm Clin Res

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Objective: The present study aims to investigate the protective effect of methanol fraction of Morus alba (MEMA) leaves against hydrogen peroxide (H2O2)-induced U87MG cell toxicity and aluminum fluoride (ALF)-induced rat toxicity. Methods: The study was divided into in vitro and in vivo sections. U87MG cell lines were pre-treated with different fractions of MEMA for 20 h and further tested against 1000 ϻM of H2O2. The best fraction from in vitro studies was used to study the protective effects against ALF-induced neurotoxicity. Rats were divided i nto five different groups, and MEMA (200 and 400 mg/kg p.o) was administered for 14 days to the animals with α-tocopherol as the standard drug treatment. Behavioral studies were assessed using Barnes maze. The major biochemical measurements included catalase, superoxide dismutase and glutathione reductase, lipid peroxidation (LPO), and acetylcholinesterase (AchE) levels. Results: In vitro studies indicated MEMA as a potential candidate followed by AQMA and ethyl acetate. The MEMA fraction was able to ameliorate ALF-induced neurotoxicity in the behavioral assessment. The higher antioxidant content in the fraction decreased the LPO levels from 250±4.07 to 115±3.22 as well as elevated the levels of most of the endogenous antioxidant enzyme levels. AchE levels were also decreased to 33.89±0.71 from 38.94±0.64. Conclusion: Although the results obtained indicate that MEMA could significantly suppress oxidative stress-induced central neuronal damage both in vitro and in vivo, further mechanistic studies are required to delineate its neuroprotective pathway.

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Exploring the anti-breast cancer potential of flavonoid analogs

Abstract: In the course of our search for new antitumor agents for breast cancer, novel flavone derivatives were synthesized, characterized and examined for their antitumor activities against breast cancer cell lines.

Cited by 15 publications

References 35 publications

Potent Nano Carriers for Targeting Breast Cancer

Potent Nano Carriers for Targeting Breast Cancer

An insight into novel therapeutic potentials of taxifolin

Neuroprotective and Cognitive Enhancing Effect of Methanolic Morus Alba Leaf Fraction in U87mg Cell Lines and Experimental Rat Model

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