An insight into novel therapeutic potentials of taxifolin

Abstract

Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees, which is often found in foods such as onions and olive oil, and is also used in commercial preparations, and has attracted the interest of nutritionists and medicinal chemists due to its broad range of health-promoting effects. It is a powerful antioxidant with excellent antioxidant, anti-inflammatory, anti-microbial and other pharmacological activities. This review focuses on the breakthroughs in taxifolin for the treatment of diseases from 2019 to 2022 according to various systems of the human body, such as the nervous system, immune system, and digestive system, and on the basis of this review, we summarize the problems of current research and try to suggest solutions and future research directions.

Revealing Medicinal Constituents of Bistorta vivipara Based on Non-Targeted Metabolomics and 16S rDNA Gene Sequencing Technology

“…Jasmonic acid is a fatty acyl compound with anticancer, anti-inflammatory, and cosmetic effects [ 68 ]. Taxifolin is a class of flavonoids that have antioxidant, anti-inflammatory, antibacterial, and bone loss prevention effects [ 69 , 70 ]. Irigenin is a class of isoflavonoids, which has mainly been derived from Belamcanda chinensis in previous studies, and it has important medicinal values, including antioxidant, anti-inflammatory, and antitumor properties [ 71 ].…”

Optimization of flavanonols heterologous biosynthesis in Streptomyces albidoflavus, and generation of auronols

“…These secondary metabolites are essential for the morphology and physiology of plants, displaying a wide range of functions, like cell growth regulation, pollinator insect attraction or protection against both biotic and abiotic stresses ( Dias et al, 2021 ). Humans can benefit from flavonoid intake as these compounds show diverse bioactive properties, such as antioxidant ( Chen et al, 2023 ; Liu et al, 2023 ), anti-inflammatory ( Chen et al, 2023 ; Liu et al, 2023 ), antitumor ( Redondo-Blanco et al, 2017 ) and cardioprotective ( Espírito-Santo et al, 2023 ), among many others.…”

“…Taxifolin ( Figure 1 ), also known as dihydroquercetin, is a flavanonol that, as aromadendrin, contains two stereocenters giving rise to four stereoisomers ( Bernatova and Liskova, 2021 ; Das et al, 2021 ). Many pharmacological properties are attributed to taxifolin, such as anti-inflammatory, antioxidant ( Liu et al, 2023 ), anti-Alzheimer, hepatoprotective, antiangiogenic, antimicrobial ( Bernatova and Liskova, 2021 ; Das et al, 2021 ), and also cosmetic ones ( Chen et al, 2023 ). Taxifolin has a higher antioxidant potential compared to other flavonoids, based on the disposition of its phenol groups and the elevated number of hydroxyl groups in its structure ( Das et al, 2021 ).…”

Tissue Lipid Profiles of Rainbow Trout, Oncorhynchus mykiss, Cultivated under Environmental Variables on a Diet Supplemented with Dihydroquercetin and Arabinogalactan

“…The pharmacological effects and mechanisms of action of dihydroquercetin (or taxifolin) have recently been reviewed [ 22 , 23 , 24 ]. Dihydroquercetin is a potent antioxidant and, thus, directly reduces the deleterious effects of ROS through radical scavenging.…”

“…Dihydroquercetin also inhibits the activity of pro-oxidative enzymes, such as myeloperoxidase, NADPH oxidase, cyclooxygenase and nitric oxide synthase [ 26 ]. As a flavonoid, dihydroquercetin has been shown to have anti-inflammatory properties [ 22 , 23 , 24 ], reducing the production of pro-inflammatory cytokines such as interleukin 1β (IL-1β) and TNF-α [ 27 , 28 ]. Dihydroquercetin affects lipid synthesis, cholesterol production and the ApoA/ApoB balance, although these effects are not caused by changes in transcription levels [ 29 , 30 ].…”