Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives

Hussain, Zahid; Thu, Hnin Ei; Amjad, Muhammad Wahab; Hussain, Fahad; Ahmed, Tarek A.; Khan, Shahzeb

doi:10.1016/j.msec.2017.03.226

Cited by 220 publications

(112 citation statements)

References 99 publications

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“…Studies have demonstrated that the nanoencapsulation of curcumin with PCL contributed to the potentiation of antioxidant action; according to the authors, nanocapsules permit slow and prolonged release of the active ingredient (Hussain et al, ; Mohammadi, Rabbani, Bahrami, Joghataei, & Moayer, ). In the case of curcumin associated with Eudragit ® polymers, researchers observed a profile of biphasic release and intestinal pH and prolonged systemic bioavailability (Khatik et al, ); these results suggested that curcumin has been released only in the gut of the sheep, where it was efficiently absorbed, possibly giving rise to our antioxidant and immune results.…”

Section: Discussionmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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The main objective of this study was to evaluate whether the addition of curcumin‐loaded nanocapsules (prepared and characterized) in the diets of dairy sheep improved milk quality. The nanocapsules were prepared using two polymers: poly‐ε‐caprolactone (PCL) and Eudragit L‐100. The nanocapsules contained 0.25 mg/ml (Nano‐Eudragit L‐100) and 2 mg/ml (Nano‐PCL) of curcumin. Dairy sheep were divided into four groups: A (control), B (30 mg free curcumin/kg concentrate), C (3 mg Nano‐PCL/kg concentrate), and D (3 mg Nano‐Eudragit/kg concentrate). We observed that the number of total leukocytes and serum globulin levels were lower in Group D than in the control (Group A) (p < 0.05). Antioxidant capacity against peroxyl radicals (ACAP) and catalase enzymes was elevated in Group D, with consequently reduced lipid peroxidation (LPO; p < 0.05). In milk, there were no differences in production and composition between groups during the experimental period (p > 0.05); however, ACAP increased and LPO decreased in milk. Practical applications Curcumin is a functional molecule with potent antioxidant, anti‐inflammatory, and antimicrobial actions, used frequently and with medical indications in human food. Free curcumin in sheep diets improves milk quality and increases its shelf life. This study showed that curcumin nanocapsules produced from the Eudragit L‐100 polymer potentiated the anti‐inflammatory and antioxidant actions of dairy sheep when used in the diet daily, at doses 10 times lower than that of free curcumin. These positive effects were reflected in higher total antioxidant capacity and lower lipid peroxidation in milk in sheep‐fed curcumin‐loaded Eudragit L‐100 nanocapsules, generating desirable milk properties. In practice, the use of nanotechnology enhances the beneficial effects of curcumin in milk, possibly creating a nutraceutical food desirable to consumers.

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Section: Discussionmentioning

confidence: 99%

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

et al. 2019

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“…Curcumin (CUR), the main active constituent of a traditionally used food additive, spice and herbal medicine Curcuma longa L., is a polyphenolic molecule possessing various bioactivities, such as antioxidant, anticancer, anti-inflammatory and anti-microbial activities etc [1][2][3]. However, CUR has very low bioavailability owing to its poor water solubility and structural stability, which is contradictory to the diversity of its pharmacological activities [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of food spice curcumin by gut bacterium Bacillus megaterium DCMB-002 and its pharmacological implications

Sun

Shen

et al. 2017

Food & Nutrition Research

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The food additive curcumin shows many benefits for human health but has low solubility and stability, which leads to its low bioavailability. After oral administration, curcumin undergoes biotransformation by gut microbiota in digestive tracts, and thus it is interesting to characterize the biotransformation products of curcumin and assess their bioactivities to help us understand the pharmacology. Herein a bacterial strain of Bacillus megaterium DCMB-002 isolated from mice feces, showed the capability of transforming curcumin to its various derivatives. The tracing high performance liquid chromatogram coupled with quadrupole time-of-flight tandem mass spectra (HPLC-Q-TOF MS n ) led to the identification of seven hydrogenation transformation metabolites through reduction, hydroxylation, demethylation and demethoxylation etc, six of which were reported for the first time. The metabolites exhibited moderate antioxidant activity. The findings provided insights into the microbial biotransformation of curcumin and roles of gut microbiota in its pharmacological effects. ARTICLE HISTORY

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“…Curcumin exhibits a number of medicinal properties including anti-diabetic [1], anti-arthritic [2], anti-oxidant [3], anti-inflammatory [4], antimicrobial [5], anti-neurodegenerative [6]and anticancer [7]. Despite the widespread applications, the beneficial effects of curcumin are hampered by its poor bioavailability which results from its high metabolic and excretion rates, poor absorption and minimal water insolubility [8]. To circumvent these obstacles, some studies have focused attention on the utilization of nanomaterials to encapsulate curcumin to enhance its bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Al-Bishri¹

2017

Int. J. Adv. Res. Biol. Sci.

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Recent works have indicated the beneficial efficacy of using nanocurcumin in addressing poor bioavailability commonly associated with native curcumin. Curcumin has been shown to alleviate hyperthyroidism induced liver dysfunction. Here we carried out a comparative study using both native curcumin and nanocurcumin to verify the superior effects of encapsulation of curcumin in nanomaterials in blunting liver dysfunction in L-thyroxine induced hyperthyroid rats. Native curcumin (NC) and poly (lactide-co-glycolic acid (PLGA) encapsulated curcumin (PNC) significantly increased liver catalase activity and reduced glutathione (GSH) levels and significantly declined malondialdehyde (MDA) levels in hyperthyroid rats. However, rats treated with PNC had significantly better ameliorative effects on these parameters than rats treated with NC. Similarly, PNC showed significantly improved effects in lowering inflammatory mediators including TNF-a, IL-6, VEGF, CRP and caspase protein levels compared to NC in hyperthyroid rats. Serum T3, T4, and TSH levels and liver functional markers including albumin, ALT, ASP and AST were better controlled in PNC treated rats than in NC treated hyperthyroid rats. DNA fragmentation as estimated by comet assay was significantly lower in PNC treated rats than in NC treated rats. Likewise, significantly fewer histopathological and ultrastructural changes were observed in liver tissue in PNC treated hyperthyroid rats. Conclusion: Our work illustrates the capability of PNC to resolve hyperthyroidism induced liver dysfunction and substantiate the findings that beneficial effects of curcumin may be maximized by improving its stability and bioavailability by its encapsulation in nanoparticles.

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Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives

Cited by 220 publications

References 99 publications

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

Low‐dose curcumin‐loaded Eudragit L‐100‐nanocapsules in the diet of dairy sheep increases antioxidant levels and reduces lipid peroxidation in milk

Biotransformation of food spice curcumin by gut bacterium Bacillus megaterium DCMB-002 and its pharmacological implications

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

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