We introduce an opportunistic scheduling to enhance the physical layer security with transmit antenna selection (TAS) in multiuser environment. We consider a wireless communication system composed of a single transmitter and multiple legitimate users in the presence of several eavesdroppers with each node having multiple antennas under quasi-static Rayleigh fading channel. The transmitter selects the best transmitting antenna and the best user to maximize signal-to-noise ratio (SNR) at the selected user. The user and eavesdropper can employ either selection combining (SC) or maximal ratio combining (MRC) to combine the received signals. New closed-form expressions for probability of positive secrecy and outage are derived. Moreover, asymptotic analysis reveals the outage diversity gain and array gain for the proposed scheme. The impact of number of users, eavesdroppers, and antennas on secrecy performance are clearly demonstrated with mathematical analysis and numerical results.