Exploring GABAergic and dopaminergic effects in a minimal model of a medium spiny projection neuron

Samuelsson, Ebba; Kotaleski, Jeanette Hellgren

doi:10.1016/j.neucom.2006.10.045

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…While these studies demonstrated a marked effect of the K IR conductance on generation and propagation of synaptic potentials, the question remained as to whether these effects would also occur in a physiologically more realistic model of an MS neuron equipped with its wide array of voltage-dependent active channels. The presence of a large number of nonlinear conductances makes it difficult to predict such effects analytically, and complex interactions between these mechanisms can sometimes lead to counter-intuitive outcomes (Williams and Stuart 2003;Samuelsson and Kotaleski 2007;Steephen and Manchanda 2009). We, therefore, used a biophysically detailed model of the NAc MS neuron, which has recently become available (Wolf et al 2005), incorporating all the 14 active conductances known to be present in these neurons, to investigate the effects of these active conductances in modulating the subthreshold down-state synaptic inputs as well as excitability in the up-state.…”

Section: Discussionmentioning

confidence: 99%

Modulation of synaptic potentials and cell excitability by dendritic KIR and KAs channels in nucleus accumbens medium spiny neurons: A computational study

John

Manchanda

2011

J Biosci

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The nucleus accumbens (NAc), a critical structure of the brain reward circuit, is implicated in normal goal-directed behaviour and learning as well as pathological conditions like schizophrenia and addiction. Its major cellular substrates, the medium spiny (MS) neurons, possess a wide variety of dendritic active conductances that may modulate the excitatory post synaptic potentials (EPSPs) and cell excitability. We examine this issue using a biophysically detailed 189-compartment stylized model of the NAc MS neuron, incorporating all the known active conductances. We find that, of all the active channels, inward rectifying K+ (KIR) channels play the primary role in modulating the resting membrane potential (RMP) and EPSPs in the down-state of the neuron. Reduction in the conductance of KIR channels evokes facilitatory effects on EPSPs accompanied by rises in local input resistance and membrane time constant. At depolarized membrane potentials closer to up-state levels, the slowly inactivating A-type potassium channel (KAs) conductance also plays a strong role in determining synaptic potential parameters and cell excitability. We discuss the implications of our results for the regulation of accumbal MS neuron biophysics and synaptic integration by intrinsic factors and extrinsic agents such as dopamine.

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Section: Discussionmentioning

confidence: 99%

Modulation of synaptic potentials and cell excitability by dendritic KIR and KAs channels in nucleus accumbens medium spiny neurons: A computational study

John

Manchanda

2011

J Biosci

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“…The striatum is the crucial component of the basal ganglia which is associated with a variety of functions including control of voluntary motor movements, procedural learning, routine behaviors or habits, (Bolam et al 2000;Samuelsson et al 2007) . Striatum receives input from the cerebral cortex and is the primary input to the basal ganglia system.…”

Section: Introductionmentioning

confidence: 99%

Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

2018

Tamap J. Eng.

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The aim of this work is to investigate the role of network organization and the neuron model type on the collective dynamic behavior of striatal population. For that purpose, two different scale neuron models which are phenomenological Izhikevich and conductance-based Hodgkin-Huxley (HH) type are used to investigate the dynamic behavior of MS neurons. Two network architectures are proposed with inhibitory and excitatory synaptic currents. In these networks, while all MS neurons affect each other with inhibitory synaptic currents, an excitatory current is applied to all MS neurons in the first layer, to represent the cortical inputs. A mathematical model of a medium spiny neuron of striatum based on HH type neuron model is proposed using different calcium channels and its dynamical behavior is investigated. It is observed that when the original HH model is used, regular spiking type behavior is observed. Including the high threshold calcium current, after hyperpolarization calcium current and voltage gated potasium current into the model improves the modeling capabilities. With extended ion channels, in addition to regular spiking behavior, bursting with resting stage are obtained. Then, Izhikevich neuron model is used in the network structures to compare the dynamic behaviors and computational time.

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Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

Steephen

Manchanda

2009

J Comput Neurosci

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Exploring GABAergic and dopaminergic effects in a minimal model of a medium spiny projection neuron

Cited by 6 publications

References 9 publications

Modulation of synaptic potentials and cell excitability by dendritic KIR and KAs channels in nucleus accumbens medium spiny neurons: A computational study

Modulation of synaptic potentials and cell excitability by dendritic KIR and KAs channels in nucleus accumbens medium spiny neurons: A computational study

Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

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