Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

Steephen, John Eric; Manchanda, Rohit

doi:10.1007/s10827-009-0161-7

Cited by 37 publications

(23 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The above results show that K IR conductance affects the amplitude and time course of EPSPs in such a way that more effective summation occurs when K IR current is inactivated. This appears to be one of the factors responsible for the enhanced overall excitability of the MS cell with K IR inactivation demonstrated in a recent study by Steephen & Manchanda [10].…”

Section: Ifmbe Proceedings Vol 39mentioning

confidence: 80%

“…It also enhances the amplitude and time course of the EPSP, resulting in better summation of the EPSPs at the soma. This, in turn, may underlie the increased excitability reported in neurons with inactivating K IR currents [10,12]. There are two major types of mammalian NAc MS neurons: (i) Substance P-expressing (SP positive) neurons, more concentrated in the shell region and projecting mainly to ventral tegmental area and, (ii) enkephalin (ENK) neurons constituting the larger fraction in the core region and primarily projecting to the ventral pallidum.…”

Section: Discussionmentioning

confidence: 99%

“…It was built based on the data obtained from published models [9], [10], using NEURON simulation platform. The model has a soma and four proximal dendrites each bifurcating to form eight middle dendrites.…”

Section: Methodsmentioning

confidence: 99%

“…Channel parameters were mostly taken from a published model [9]. The time constant values for modeling the K IR channels with non-inactivating and inactivating currents were obtained from a recently published modified model [10] in which, the parameters were derived from mammalian (rat) MS neurons instead of those from the non-mammalian Aplysia neurons used by Wolf and his colleagues [9]. Single EPSP was generated using a colocalized NMDA-AMPA synapse modeled using published data.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Inactivation of KIR current modulates subthreshold synaptic inputs in striatal medium spiny neurons: A computational study

John¹,

Steephen

Manchanda

2013

IFMBE Proceedings

View full text Add to dashboard Cite

Abstract-Nucleus accumbens (NAc) has been identified as a major structure of brain involved in goal-directed behavior and learning. However, the cellular mechanisms underlying this are still not clear. The medium spiny (MS) neurons, the primary neurons of NAc, possess a wide variety of dendritic active conductances that are capable of modulating the subthreshold synaptic inputs impinging on them. K IR conductance, being a major conductance active during resting conditions, is a potential candidate to influence this modulation. In 40% of NAc MS neurons, the current through this conductance is found to inactivate significantly. In this study we investigate the role of this inactivation in modulating the subthreshold synaptic inputs and their integration. This in turn will influence the excitability of the cell as well as its synaptic plasticity that underlie the learning process in brain. We find that inactivation of K IR current depolarizes the RMP of the cell and increases the cell's input resistance. This enhanced input resistance, in turn, augments the EPSP parameters such as amplitude and half width, thus promoting better temporal summation of synaptic inputs and consequently will result in enhanced cell excitability.

show abstract

Section: Ifmbe Proceedings Vol 39mentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Inactivation of KIR current modulates subthreshold synaptic inputs in striatal medium spiny neurons: A computational study

John¹,

Steephen

Manchanda

2013

IFMBE Proceedings

View full text Add to dashboard Cite

show abstract

“…In ventral striatum, inward rectifying potassium (K IR ) currents in 40% of MSNs inactivate [1]. K IR current inactivation appears to alter spike frequency and onset during upstates [2]. However, it is not known whether these translate into significant changes in calcium dynamics in the dendrites.…”

Section: Introductionmentioning

confidence: 99%