Exploring energy loss by vector flow mapping in children with ventricular septal defect: Pathophysiologic significance

Honda, Takashi; Takanashi, Manabu; Kitagawa, A.; Ando, Hisashi; Kimura, Sumito; Oka, Norihiko; Miyaji, Kagami; Ito, Masahiro

doi:10.1016/j.ijcard.2017.06.035

Cited by 17 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We believe that regional elevation of the viscous EL nearby the infarct region may increase the work requirement of the border zone tissues during cardiac contraction, thus augmenting the oxygen consumption to activate the additional chemical work. This is further supported by a recent study, which observed a positive correlation between intraventricular EL and serum brain natrium peptide (BNP), predominantly secreted from the ventricles in response to volume or pressure load . In another study, serum BNP levels have been shown to reflect compensatory mechanism to preserve heart function .…”

Section: Discussionmentioning

confidence: 99%

Impact of myocardial infarction on intraventricular vortex and flow energetics assessed using computational simulations

Chan

Bakir

Abed

et al. 2019

Numer Methods Biomed Eng

View full text Add to dashboard Cite

Flow energetics have been proposed as early indicators of progressive left ventricular (LV) functional impairment in patients with myocardial infarction (MI), but its correlation with individual MI parameters has not been fully explored. Using electro-fluid-structure interaction LV models, this study investigated the correlation between four MI parameters: infarct size, infarct multiplicity, regional enhancement of contractility at the viable myocardium area (RECVM), and LV mechanical dyssynchrony (LVMD) with intraventricular vortex and flow energetics. In LV with small infarcts, our results showed that infarct appearance amplified the energy dissipation index (DI), where substantial viscous energy loss was observed in areas with high flow velocity and near the infarct-vortex interface. The LV with small multiple infarcts and RECVM showed remarkable DI increment during systole and diastole. In correlation analysis, the systolic kinetic energy fluctuation index (E′) was positively related to ejection fraction (EF) (R 2 = 0.982) but negatively correlated with diastolic E′ (R 2 = 0.970). Diastolic E′ was inversely correlated with vortex kinetic energy (R 2 = 0.960) and vortex depth (R 2 = 0.876). We showed an excessive systolic DI could differentiate infarcted LV with normal EF from healthy LV. Strong flow acceleration, LVMD, and vortex-infarct interactions were predominant factors that induced excessive DI in infarcted LVs. Instead of causing undesired flow turbulence, high systolic E′ suggested the existence of energetic flow acceleration, while high diastolic E′ implied an inefficient diastolic filling. Thus, systolic E′ is not a suitable early indicator for progressive LV dysfunction in MI patients, while diastolic E′ may be a useful index to indicate diastolic impairment in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of myocardial infarction on intraventricular vortex and flow energetics assessed using computational simulations

Chan

Bakir

Abed

et al. 2019

Numer Methods Biomed Eng

View full text Add to dashboard Cite

show abstract

“…Hayashi et al and Akiyama et al have provided EL reference values within the left ventricle in children and adults. Moreover, a recent study performed by Honda et al revealed that in children with ventricular septal defects, diastolic, peak, and systolic EL of the left ventricle were significantly and positively correlated with catheterization parameters (RV systolic pressure and RV end‐diastolic pressure), and serum brain natrium peptide levels. The same group also once used EL as a novel parameter to quantitatively evaluate the pressure overload on the intra‐OP caused by stenotic lesions in a 15‐month‐old boy who suffered from RV failure 8 months after double outlet right ventricle repair .…”

Section: Discussionmentioning

confidence: 96%

Right Ventricular Dissipative Energy Loss Detected by Vector Flow Mapping in Children: Characteristics of Normal Values

Chen

et al. 2018

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…Further studies assessing a large population cohort are required to validate our findings. Second, as we primarily analyzed two-dimensional images, with software that assumed 2D flow, actual regurgitation jet is complex 3D flow, and a three-dimensional evaluation is needed to ensure accurate assessment of the severity of AR 13,17 . Three-dimensional VFM is currently unavailable.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies attempted to elucidate the mechanism of thrombus formation in the left ventricle 7,8 . VFM analysis of valvular [9][10][11][12] and congenital heart disease [13][14][15] can reportedly reveal and evaluate the effectiveness of the surgical treatment. As it does not require the use of contrast, this VFM technology can be easily used in routine clinical practice to assess ventricular vortices and predict patients' outcome 16 .…”

Section: Introductionmentioning

confidence: 99%

Preoperative left ventricular energy loss in the operating theater reflects subjective symptoms in chronic aortic regurgitation

Kainuma

Akiyama

Naito

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Objective: There is currently no subjective, definitive evaluation method for therapeutic indication other than symptoms in aortic regurgitation. Energy loss, a novel parameter of cardiac workload, can be visualized and quantified using echocardiography vector flow mapping. The purpose of the present study was to evaluate whether energy loss in patients with chronic aortic regurgitation can quantify their subjective symptoms more clearly than other conventional metrics. Methods: We studied 15 patients undergoing elective aortic valve surgery for aortic regurgitation. We divided the patients into symptomatic and asymptomatic groups using their admission records. We analyzed the mean energy loss in one cardiac cycle using transesophageal echocardiography during the preoperative period. The relationships between symptoms, energy loss, and other conventional metrics were statistically analyzed. Results: There were seven and eight patients in the symptomatic and asymptomatic groups, respectively. The mean energy loss of one cardiac cycle was higher in the symptomatic group (121 [96 to 184]) than in the asymptomatic group (87 [80 to 103]) (p=0.040), whereas the diastolic diameter was higher in the asymptomatic group (65 [59 to 78]) than in the symptomatic group (57 [51 to 57]) (p=0.040). There was no significant difference between the symptomatic and asymptomatic groups in terms of other conventional metrics. Conclusions: An energy loss can quantify patients' subjective symptoms more clearly than other conventional metrics. The small sample size is the primary limitation of our study, further studies assessing larger cohort of patients are warranted to validate our findings.

show abstract

Exploring energy loss by vector flow mapping in children with ventricular septal defect: Pathophysiologic significance

Cited by 17 publications

References 25 publications

Impact of myocardial infarction on intraventricular vortex and flow energetics assessed using computational simulations

Impact of myocardial infarction on intraventricular vortex and flow energetics assessed using computational simulations

Right Ventricular Dissipative Energy Loss Detected by Vector Flow Mapping in Children: Characteristics of Normal Values

Preoperative left ventricular energy loss in the operating theater reflects subjective symptoms in chronic aortic regurgitation

Contact Info

Product

Resources

About