Exploring associations of maternal sleep during periconceptional period with congenital heart disease in offspring

et al. 2020

Preprint

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Background: Early life exposure in the uterus had a long-term effect on children's health. As the prevalence of allergies is increasing with a remarkable sex difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein sleep, physical activity, and screen time during pregnancy is associated with childhood respiratory allergies. The sex difference would be examined. Methods: 6236 mother-child pairs from Shanghai Children Allergy Study (SCAS) were enrolled, The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate respiratory allergic diseases. Results: 14.6%, 16.2%, and 21.0% of children had asthma, wheeze, and allergic rhinitis, respectively. Maternal short sleep duration, lack of physical activity, and too much screen exposure during pregnancy could increase the risk of childhood respiratory allergies, however, the significance was found only in males. Moreover, a dose-response trend was clearly shown, any two of the three combined could increase the risk (OR,1.921; 95%CI,1.217-3.033), and the coexistence of all three further amplified the risk (OR,2.412; 95%CI,1.489-3.906). The findings can be verified in allergen test subgroup and each single type of respiratory allergies in most cases. Conclusions: Maternal unhealthy behaviors during pregnancy could increase the risk of childhood respiratory allergies with a dose-response pattern. Males were more susceptible to the association. The identification of modifiable maternal risk behaviors lies in the emphasis of intervention in early life to face up increasing childhood allergies.

Section: Maternal Behavioral Variablessupporting

confidence: 61%

Effect of Maternal Sleep, Physical Activity and Screen Time during Pregnancy on the Risk of Childhood Respiratory Allergies: a Sex-specific Study

Chen

Lyu

et al. 2020

Preprint

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“…The optimal duration of sleep for pregnant woman is not yet known, the cutoff for short sleep duration was de ned as less than 8 hours/day in this study with the reference of most studies. 18,19 Meanwhile, 8 hours/day was close to the 25th percentile of the distribution of total sleep duration during pregnancy in our dataset. The answers for daily physical activity were classi ed into two groups: <1hr./day vs. ≥1hrs./day; and screen exposure were classi ed into two groups: ≥2hrs./day vs. <2hrs./day.…”

Section: Maternal Behavioral Variablessupporting

confidence: 61%

Effect of Maternal Sleep, Physical Activity and Screen Time during Pregnancy on the Risk of Childhood Respiratory Allergies: a Sex-specific Study

Chen

Lyu

et al. 2020

Preprint

Self Cite

Background: Early life exposure in the uterus had long-term effect on children's health. As the prevalence of allergies is increasing with a remarkable gender difference, very few studies have traced back to their early origins. We sought to investigate if maternal behavioral exposure, herein sleep, physical activity and screen time during pregnancy, is associated childhood respiratory allergies. The sex difference would be examined. Methods: 6236 mother-child pairs from Shanghai Children Allergy Study (SCAS) were enrolled, The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate respiratory allergic diseases. Results: 14.6%, 16.2% and 21.0% of children had asthma, wheeze, and allergic rhinitis, respectively. Maternal short sleep duration, lack of physical activity and too much screen exposure during pregnancy could increase the risk of childhood respiratory allergies. Moreover, a dose-response trend was clearly shown. However, the significance was found only in males, any two of the three combined could increase the risk (OR,1.921; 95%CI,1.217-3.033), and the coexistence of all three further amplified the risk (OR,2.412; 95%CI,1.489-3.906). The findings can be verified in allergen test subgroup and single type of respiratory allergies in most cases. And gender difference was identified, all above associations were mainly observed in males. Conclusions: Maternal unhealthy behaviors during pregnancy could increase the risk of childhood respiratory allergies with a dose-response pattern. Males were more susceptible to the association. The identification of modifiable maternal risk behaviors lies in the emphasis of intervention in early life to face up increasing childhood allergies.

“…Information on socio-demographic characteristics and parental health-related behaviours was retrospectively collected through the Parental Behaviours and Environmental Exposure Questionnaire, a self-made questionnaire used in our previous study. 12 For both cases and controls, only those mothers who signed the informed consent were invited to fill out the questionnaires whilst in hospital.…”

Section: Methodsmentioning

confidence: 99%

“…The detailed information of the case-control study has been described elsewhere. 12 The CHD diagnoses were based on the codes of the International Classification of Diseases, the Tenth Revision, Clinical Modification. A team of experts, including paediatric cardiothoracic surgeons and fetal ultrasonologists, evaluated and ensured the accuracy of the final diagnosis.…”

Section: Study Design and Subjectspatientsmentioning

confidence: 99%

Periconceptional use of cod liver oil, a vitamin D source, could decrease the risk of CHD in offspring

Zhao

et al. 2020

Cardiol Young

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Objective: To explore if there is association between vitamin D supplementation through cod liver oil ingestion around the periconceptional period and the risk of developing severe CHD in offspring. Furthermore, we would examine the interaction between vitamin D and folic acid supplementation in the association. Methods: A case–control study was conducted in Shanghai Children’s Medical Center, in which, a total of 262 severe CHD cases versus 262 controls were recruited through June 2016 to December 2017. All children were younger than 2 years. To reduce potential selection bias and to minimise confounding effects, propensity score matching was applied. Results: After propensity score matching, vitamin D supplementation seemed to be associated with decreased odds ratio of severe CHD (odds ratio = 0.666; 95% confidence intervals: 0.449–0.990) in the multivariable conditional logistic analysis. Furthermore, we found an additive interaction between vitamin D and folic acid supplementation (relative excess risk due to interaction = 0.810, 95% confidence intervals: 0.386–1.235) in the association. Conclusion: The results suggested that maternal vitamin D supplementation could decrease the risk of offspring severe CHD; moreover, it could strengthen the protective effect of folic acid. The significance of this study lies in providing epidemiological evidence that vitamin D supplementation around the periconceptional period could be a potential nutritional intervention strategy to meet the challenge of increasing CHD.