Gender medicine is attracting more and more attention also in clinical practice [1]. Differences between genders exist in many diseases. The evaluation of the gender impact on asthma arouses current and outstanding interest and is an interesting research field, as recently pointed out [2].Currently, asthma control is the cornerstone strategy in the management of patients with asthma, as stated by the Global Initiative for Asthma (GINA) document [3]. The asthma control evaluation should be based on a global assessment of symptoms, lung function, medications' use, limitations, and respiration perception. The asthma control perception may be assessed in a standardized way by the Asthma Control Test (ACT) questionnaire. In this regard, a recent study evaluated a large group of outpatients with asthma in a real-world setting [4]. Interestingly, the asthma control, assessed by objective and subjective measures, was not influenced by gender. However, differences between female and male adults concerned only lung function and smoking. Asthmatic women had higher FVC and FEV1 values than men, but men smoked more than women. Otherwise, there were no significant differences between genders. Consistently, we reported no difference between female and male children with asthma concerning the lung function and the perception of breathlessness [5].However, some pediatric studies do not investigate the assessment of asthma control. In this regard, the Italian Society of Paediatric Allergy and Immunology recently established a prospective study ("ControL'Asma") to investigate the asthma control in children and adolescents managed in clinical practice. As asthma and allergy are dynamic events, the present study aimed to compare genders about asthma control and other clinical-functional characteristics in children and adolescents recruited in a real-world setting, such as Italian pediatric third-level allergy and asthma clinics.This cross-sectional study included 471 children and adolescents consecutively visited across 10Italian pediatric third-level allergy clinics. Asthma diagnosis was performed following the GINA document criteria. All patients were currently treated according to the GINA guidelines based on the asthma control level.