Exploring Antiurolithic Effects of Gokshuradi Polyherbal Ayurvedic Formulation in Ethylene-Glycol-Induced Urolithic Rats

Shirfule, Amol L.; Racharla, Venkatesh; Qadri, Syed S.Y.H.; Khandare, Arjun L.

doi:10.1155/2013/763720

Cited by 17 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A significant decrease in SOD and CAT activity in kidney homogenate was observed in lithiatic rats. Similar results have been reported previously [39][40][41].…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Kyada¹,

Mansuri²,

Patel³

2017

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

Aim: Antiurolithiatic activity of magnesium lactate gluconate (MLG) and aqueous extract of Garcinia cambogia (GC) fruit was studied. Materials and Methods: The study was performed during December 2016 to April 2017. Urolithiasis was induced in male Wistar rats by administration of 0.75% v/v ethylene glycol for 21 days. From 8 th day onward, intervention with MLG (200 and 400 mg/kg b.w.) and GC (100 and 200 mg/kg b.w.) was started. At the end of the treatment period, biochemical parameters affecting renal stone formation were estimated in the serum, urine, kidney homogenate, and histopathology of harvested kidneys was performed. Results: From in vivo evaluation, it was observed that MLG 400 mg/kg b.w., GC 100 mg/kg b.w., and GC 200 mg/kg b.w. significantly reduced nitrogenous waste products in serum (blood urea nitrogen, creatinine, and uric acid) as well as calculogenic promoters in urine (phosphate and oxalate) and kidney homogenate (calcium, phosphate, and oxalate) when compared to disease control animals. The MLG 200 and MLG 400 were ineffective in restoring superoxide dismutase (SOD) and catalase (CAT) enzyme activity, whereas GC 100, GC 200, and Cystone ® 400 mg/kg b.w. significantly elevated SOD and CAT enzymes in urolithiatic rat kidney. Conclusions: MLG and GC extracts are capable of preventing calcium oxalate (CaOx) crystal formation and subsequent deposition in renal tubules. The principle mechanism underlying nephroprotective effect of test drugs might be attributed to their calcium ion chelating ability and CaOx crystallization inhibitory activity. It is further asserted that GC was more potent than MLG in overall kidney protection by virtue of its antioxidant potential.

show abstract

“…A significant decrease in SOD and CAT activity in kidney homogenate was observed in lithiatic rats. Similar results have been reported previously [39][40][41].…”

Section: Discussionsupporting

confidence: 93%

“…A significant increase in kidney TBARS levels on EG and AC challenge is indicative of excessive ROS generation and subsequent depletion of endogenous antioxidant enzymes [39][40][41]. Accumulation of lipid peroxides may further damage EG-administered rat kidneys.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Kyada¹,

Mansuri²,

Patel³

2017

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

show abstract

“…Urine elements such as phosphate and magnesium were not significantly affected by either urolithiasis or saffron extract treatments which is in agreement with some previous studies (Shirfule et al, 2013[ 29 ]).…”

Section: Discussionsupporting

confidence: 92%

Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats

Amin

Feriz

Hariri

et al. 2015

EXCLI Journal; 14:Doc411; ISSN 1611-2156

View full text Add to dashboard Cite

“…Urolithiasis is a common urologic disorder with high prevalence and recurrence [ 1 – 4 ]. It has been reported that kidney stones are a significant and independent risk factor for chronic kidney disease in the general population.…”

Section: Introductionmentioning

confidence: 99%

An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease

Shen

Man

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Pharmacological therapy for urolithiasis using medicinal plants has been increasingly adopted for the prevention of its recurrence. A Drosophila melanogaster model developed for translational research of urolithiasis was applied to evaluate agents with potential antilithic effects and calcium oxalate (CaOx) formation. Potential antilithic herbs were prepared in a mixture of food in a diluted concentration of 5,000 from the original extract with 0.5% ethylene glycol (EG) as the lithogenic agent. The control group was fed with food only. After 3 weeks, flies (n ≥ 150 for each group) were killed using CO2 narcotization, and the Malpighian tubules were dissected, removed, and processed for polarized light microscopy examination of the crystals. The crystal formation rate in the EG group was 100.0%. In the study, 16 tested herbal drugs reached the crystal formation rate of 0.0%, including Salviae miltiorrhizae, Paeonia lactiflora, and Carthami flos. Scutellaria baicalensis enhanced CaOx crystal formation. Two herbal drugs Commiphora molmol and Natrii sulfas caused the death of all flies. Our rapid screening methods provided evidence that some medicinal plants have potential antilithic effects. These useful medicinal plants can be further studied using other animal or human models to verify their effects.

show abstract

Exploring Antiurolithic Effects of Gokshuradi Polyherbal Ayurvedic Formulation in Ethylene-Glycol-Induced Urolithic Rats

Cited by 17 publications

References 25 publications

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Protective effect of magnesium lactate gluconate and Garcinia cambogia fruit extract in experimentally induced renal calculi in rats

Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats

An Emerging Translational Model to Screen Potential Medicinal Plants for Nephrolithiasis, an Independent Risk Factor for Chronic Kidney Disease

Contact Info

Product

Resources

About