2021
DOI: 10.14309/ajg.0000000000001149
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Exploratory Comparative Effectiveness Trial of Green Kiwifruit, Psyllium, or Prunes in US Patients With Chronic Constipation

Abstract: INTRODUCTION: Psyllium and prunes are proven treatments for chronic constipation (CC). Asian studies suggest that kiwifruit may also benefit CC symptoms. We report a partially randomized, comparative effectiveness trial evaluating kiwifruit, psyllium, and prunes in US patients with CC. METHODS: Adults with CC at a US medical center were randomized to 3 natural treatments. Eligible patients had ≤3 complete spontaneous bowel movements (CSBMs) per week and… Show more

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Cited by 33 publications
(72 citation statements)
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References 21 publications
(29 reference statements)
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“…In total, 229 articles (PubMed: 85; EMBASE: 106; Cochrane Library: 38) were retrieved, and eight of them, describing nine clinical studies, were considered eligible for inclusion in this review [30][31][32][33][34][35][36][37]. The PRISMA flow diagram summarising the article selection process is displayed in Figure 1.…”
Section: Qualitative Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In total, 229 articles (PubMed: 85; EMBASE: 106; Cochrane Library: 38) were retrieved, and eight of them, describing nine clinical studies, were considered eligible for inclusion in this review [30][31][32][33][34][35][36][37]. The PRISMA flow diagram summarising the article selection process is displayed in Figure 1.…”
Section: Qualitative Resultsmentioning
confidence: 99%
“…Most included trials were controlled interventional studies with a cross-over design. In seven out of nine studies, the intervention was associated with a significant increase in complete bowel movements or defecation frequency [30,[32][33][34][35][36][37]; in seven out of nine studies, the intervention was associated with a significant decrease in stool consistency (see Tables 3 and 4 for further details) [30][31][32][33]35,37]. Studies A, C, D, and F were characterised by a good methodological quality (Jadad score ≥ 3), thus providing the highest level of available scientific evidence (Table 2).…”
Section: Qualitative Resultsmentioning
confidence: 99%
“…Plums (species of the genus Prunus), in the form of dried plums (prunes) or plum juice, are the most widely investigated for their impact on gut motility and constipation, with 7 RCTs and a systematic review published in total about these effects, [68][69][70][71][72][73][74][75][76] yet few of them looked into mechanistic outcomes. One RCT in healthy males, reported a higher fecal weight after the consumption of 100 g/d of prunes for four weeks compared to 360 mL of grape juice, with no changes in fecal water content 76 .…”
Section: Stone Fruitsmentioning
confidence: 99%
“…The authors conclude that daily consumption of three gold-fleshed kiwis is associated with a significant increase in bowel frequency and a reduction in pain and gastrointestinal discomfort. Chey et al report a partially randomized, comparative effectiveness trial evaluating kiwifruit, psyllium, and prunes in 79 patients with CC [57]. Eligible patients had <three complete spontaneous bowel movements (CSBMs) per week and were partially randomized to green kiwifruit (2/d), prunes (100 g/d), or psyllium (12 g/d) for 4 weeks.…”
Section: The Role Of Foodmentioning
confidence: 99%