Exploration the active compounds of Astragali Radix in treatment of adriamycin nephropathy by network pharmacology combined with transcriptomic approach

Li, Aiping; He, Shengsheng; Zhang, Wang-Ning; Zhang, Lichao; Li, Ke; Qin, Xuemei

doi:10.1016/j.jep.2019.112537

Cited by 23 publications

(12 citation statements)

References 35 publications

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“…, progressive proteinuria, lipid dys-homeostasis, tubulointerstitial damage, and renal fibrosis) are similar to those observed in human NS. 7,8 The detailed mechanisms of ADR-induced NS remain unclear. Understanding the mechanisms involved in renal injury is important for developing novel therapies for the treatment and prevention of NS.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of procyanidin B2 on adriamycin-induced nephrotic syndrome mice: the multi-action mechanism for ameliorating glomerular permselectivity injury

Zhao

Tang

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Beneficial effects of procyanidin B2 on adriamycin-induced nephrotic syndrome mice: the multi-action mechanism for ameliorating glomerular permselectivity injury

Zhao

Tang

et al. 2022

Food Funct.

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“…The source plants are mainly distributed in Shanxi, Inner Mongolia and Gansu in China (Fu et al, 2014). AR has immune‐enhancing (Wang et al, 2012), anti‐tumor (Li, He, et al, 2020; Li, Sun, et al, 2020), anti‐inflammatory (Ying et al, 2021), hepatoprotective (Zou et al, 2021), antioxidant (Wang, Ding, et al, 2021), antiviral (Liang et al, 2019) and other effects, and is widely used in drugs, cosmetics, food, health products and beverages (Napolitano et al, 2013). AR appears most frequently in herbal prescriptions for the prevention of New Coronary Pneumonia (COVID‐19) and has received a lot of attention from scholars (Chinsembu, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…As the network pharmacology is rapidly developing, there has been a shift from a "one target, one drug" to a "network target, multicomponent" strategy, which has drawn attention because it conforms to the characteristics of the holistic theory of traditional Chinese medicines (TCMs) (Zhang et al, 2016). Most of the current studies on the network pharmacology of AR are related to a particular disease to specifically show the association, such as type 2 diabetes mellitus (Guo et al, 2019), chronic atrophic gastritis (Xu et al, 2020), liver fibrosis (Wang et al, 2019) and adriamycin nephropathy (Li, He, et al, 2020). These show that AR is associated with a variety of diseases.…”

mentioning

confidence: 99%

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

Guo

Sha

et al. 2022

Biomedical Chromatography

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Nowadays, cultivated variants and adulterants of Astragali Radix (AR) have flooded the market, causing the quality assurance of AR to be challenging. To address this issue, we combined network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of AR. Specifically, through network pharmacology, a complete understanding of the active components and pharmacological activities of AR was established. In addition, establishing fingerprint profiles and multicomponent quantitation by high-performance liquid chromatography (HPLC) is convenient and comprehensive, and can more fully reflect the overall situation of the distribution of various chemical components. To evaluate and differentiate AR from different origins, hierarchical cluster analysis and principal component analysis were performed. The result showed that AR acts synergistically through multiple targets and pathways. The content of chemical components in AR from different origins varied significantly. Combining network pharmacology and multicomponent quantification results, astragaloside II and IV and formononetin can be used as quality markers for the quality control of AR. This study provides a comprehensive and reliable strategy for the quality evaluation of AR and identifies its quality markers to ensure the quality of the herb.

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“…However, the potential active ingredients and molecular mechanism of ZJP on UC are hardly clarified. With the rapid development of bioinformatics, systems biology, and polypharmacology, the pharmacology method based on network pharmacology has been proved to be an effective means to explore the compatibility and mechanisms of traditional Chinese medicine [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis

Wei

Ren

Jing

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Zuojin Pill (ZJP), a classic prescription, has the potential to prevent ulcerative colitis (UC). However, the active components and mechanisms of ZJP are still arcane. This study aimed to use a network pharmacology approach to find the bioactive compounds and potential action mechanisms of ZJP in the treatment of UC. Methods. Firstly, the components and putative targets of ZJP were collected based on herbal medicine target databases, and a network containing the interaction between the targets of ZJP and the potential therapeutic targets of UC was established. Then, topological parameters were calculated to identify the key targets in the network and, in turn, to import them into the David database to perform path enrichment analysis. Results. 14 potential therapeutic components of ZJP and 26 key targets were obtained. These targets were related to signal transduction, MAPK cascade, inflammatory response, immune response, and the apoptotic process of UC. Moreover, the PI3K-Akt signaling pathway, MAPK signaling pathway, toll-like receptor signaling pathway, and Prolactin signaling pathway were predicted to participate in ZJP treating UC. Among them, 14 active components of ZJP directly regulate these pathways. Conclusion. ZJP could alleviate UC through the predicted components and mechanisms. The 14 predicted active components of ZJP may mainly play a therapeutic role for UC through synergistic regulation of the PI3K-Akt signaling pathway and MAPK signaling pathway.

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Exploration the active compounds of Astragali Radix in treatment of adriamycin nephropathy by network pharmacology combined with transcriptomic approach

Cited by 23 publications

References 35 publications

Beneficial effects of procyanidin B2 on adriamycin-induced nephrotic syndrome mice: the multi-action mechanism for ameliorating glomerular permselectivity injury

Beneficial effects of procyanidin B2 on adriamycin-induced nephrotic syndrome mice: the multi-action mechanism for ameliorating glomerular permselectivity injury

Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix

Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis

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