Exploration on the Mechanism of Ubiquitin Proteasome System in Cerebral Stroke

Abstract

Stroke’s secondary damage, such as inflammation, oxidative stress, and mitochondrial dysfunction, are thought to be crucial factors in the disease’s progression. Despite the fact that there are numerous treatments for secondary damage following stroke, such as antiplatelet therapy, anticoagulant therapy, surgery, and so on, the results are disappointing and the side effects are numerous. It is critical to develop novel and effective strategies for improving patient prognosis. The ubiquitin proteasome system (UPS) is the hub for the processing and metabolism of a wide range of functional regulatory proteins in cells. It is critical for the maintenance of cell homeostasis. With the advancement of UPS research in recent years, it has been discovered that UPS is engaged in a variety of physiological and pathological processes in the human body. UPS is expected to play a role in the onset and progression of stroke via multiple targets and pathways. This paper explores the method by which UPS participates in the linked pathogenic process following stroke, in order to give a theoretical foundation for further research into UPS and stroke treatment.

Proteomic analysis of jugular venous blood in acute large vessel occlusion stroke with futile recanalization

“…Based on the GO analysis, we found an abnormality mainly associated with oxidative stress before EVT, whereas after EVT, the abnormality was primarily related to immune regulation. Besides, the ubiquitin-proteasome system (UPS) is expected to play a role in the onset and progression of stroke via multiple targets and pathways, 17 and is closely related to the pathways of post-stroke related pathological changes such as mitochondrial autophagy, oxidative stress, hypoxia and inflammatory response. 18 We found that the expression of two proteasome core subunits, proteasome subunit alpha type-6 (PreV, FR up-regulated) and proteasome subunit alpha type-5 (PostV, FR down-regulated), which belong to component of the 20S core proteasome complex that participates in the degradation of ubiquitinated proteins, were dysregulated inconsistently.…”

Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study

“…The ubiquitin proteasome pathway is involved in the degradation of proteins and is key in the maintenance of the correct neuronal and synaptic function. After stroke, different pathological pathways are activated in response to the neuronal injury such as mitochondrial autophagy, oxidative stress and inflammatory response [ 53 ]. All these processes are related to the ubiquitin proteasome system.…”

“…All these processes are related to the ubiquitin proteasome system. The specific role of the ubiquitin proteasome system in physiological and pathological processes after stroke is still in investigation but it has been suggested as a potential target for new drugs [ 53 ].…”