Exploration of the main active components and pharmacological mechanism of Yerba Mate based on network pharmacology

Yue, Zhaodi; Fu, Hui; Ma, Huiqin; Li, Li; Zhang, Feng; Yin, Yadong; Wang, Fangqi; Du, Bingyu; Liu, Yibo; Zhao, Ruyan; Sun, Helin; Zhang, Zhongwen; Yu, Shaohong

doi:10.5603/ep.a2022.0026

Cited by 1 publication

(1 citation statement)

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“…Researchers indicate the possibility of using its bioactive ingredients in the treatment of as many as 350 diseases, including breast cancer, asthma and Alzheimer's disease. They determined that the target of the pharmacological action of yerba mate is mainly amyloid-beta precursor protein and vascular endothelial growth factor A [6]. Among the many biological properties of YM, the protective effect on the cardiovascular system and the prevention of obesity are also noteworthy [7,8].…”

Section: Health-promoting Propertiesmentioning

confidence: 99%

The correlation between Yerba Mate and cancer - a review

Wróblewska

Wróblewski

Zajączkowska

et al. 2023

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Introduction and objective Yerba Mate (YM) is a popular drink obtained from the dried and ground leaves of the Ilex paraguariens. The beneficial effects of Yerba Mate on the cardiovascular system, lipid-lowering, anti-diabetic, hepatoprotective and stimulating properties are known, however, there are also reports supporting its toxicity, that the consumption of Yerba Mate may predispose to the development of cancer. The purpose of this article is to present and organize information on the correlation between drinking Yerba Mate and cancer. Review methods A review of the available literature was performed by searching the PubMed and Google Scholar databases using the following keywords: Yerba Mate and cancer, Yerba Mate. Abbreviated description of the state of knowledge Substances contained in Yerba Mate have a positive impact on the human body. They exert health-promoting effects, e.g. increasing HDL levels and enhancing the antioxidant effect. A particularly desirable effect of Yerba Mate is its modulating effect on the course of the carcinogenesis process. Current knowledge on this subject is not complete. There are no evidences that substances in Yerba Mate without other risk factors increase the risk of oesophageal cancer. It is worth emphasizing that the properties of the Yerba Mate components are related to the reduction of the development of metastases of other cancers. Summary Despite the carcinogenic PAHs contained in the YM extract, there is no clear evidence that drinking it alone, without taking into account the temperature of the drink, could predispose to the development of esophageal cancer. Many substances found in YM have a beneficial effect on the human body.

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Section: Health-promoting Propertiesmentioning

confidence: 99%