EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

Abstract

To establish the wound healing activity of aqueous and ethanolic extract of roots of Morus alba. Two models were performed to evaluate the wound healing activity i.e., Incision and Excision model. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization was established for both the extracts. Reference standard drug was Aloe vera ointment for comparison with other groups. From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups. In conclusion, our findings suggest that aq. extract of Morus alba possess better healing ability than the ethanolic extract.

EFFICACY OF HONEY BEE AND <I>FAGOPYRUM ESCULENTUM</I> MOENCH OINTMENT IN THE TREATMENT OF SUB CHRONIC WOUND IN RABBITS: A CASE CONTROL STUDY

“…Wound healing is stepwise process, which consists of different phases such as hemostasis, inflammation, proliferative and remodeling (Kaushik et al, 2013). This process is often negatively affected by microbial infection or pathological condition leading into a development of chronic wound (Polakovicova et al, 2011).…”

Aktivitas Anti Inflamasi dan Penyembuhan Luka dari Ekstrak Kulit Batang Murbei (Morus alba L.)

“…Golongan senyawa bioaktif yang terkandung dalam tanaman murbei (Morus alba L.) sebagian besar merupakan zat polifenol, flavonoid, antosianin, lektin, oligosakarida, glikosida, zat anti-bakteri, asam lemak tak jenuh yang terdapat pada daun, batang, buah dan akar (Lin & Lay, 2013). Golongan kandungan kimia yang lain telah dilaporkan seperti tanin, steroid, saponin dan senyawa kimia lainnya (Kaushik et al, 2013). Bagian batang murbei mengandung senyawa seperti triterpenoid (alfa-betaamyrin, sitosterol, sitosterol-alfa-glucoside), kumarin (umbelliferone dan scopoletin) dan flavonoid (morusin, siklomorusin dan oxyhidromorusin).…”

Transcriptomic Analysis Reveals Wound Healing of Morus alba Root Extract by Up‐Regulating Keratin Filament and CXCL12/CXCR4 Signaling

“…For these reasons, the total demand of the world market for herbal products is at around $83 billion, and Europe accounts for over 50% of the total. A previous study suggested the potential healing action by performing test on treatment with MA extract (Kaushik et al ., ). However, it was not sufficient to explain the mode of action of the extract nor wound epithelialization at the molecular level.…”