Exploration of a Multicapillary Column for Use in Elevated Speed Gas Chromatography

Baumbach, Jan; Eiceman, Gary A.; Klockow, D.; Sielemann, Stefanie; Irmer, Andreas

doi:10.1080/03067319708028366

Cited by 39 publications

(11 citation statements)

References 26 publications

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“…Suitable columns for IMS are the so called Multi-capillary columns (MCC), which were created at what is now known as the Institute for Ap-plied Physics and the Institute of Catalysis, both in Novosibirsk, Russia, 25,26 and commercialized by the companies SIBERTECH (Novosibirsk, Russia) and ALLTECH (U.S.). The columns consist of a capillary bundle of over 1000 individual capillaries with inner diameters of 43 m. Measurements to characterize these columns performed previously 27 show that the number of theoretical plates per column was high enough (5000 per meter) to merit further evaluation. The sizes of these columns, up to 30 cm for rodshaped columns and up to 100 cm for spiral columns and 3 mm in bundle diameter with potential high volumetric flows are advantageous for portable instruments that perform best at elevated flow rates, such as those necessary for IMS operation.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of benzene, toluene, and m‐xylene with the use of a UV–ion mobility spectrometer

Sielemann

Baumbach

Schmidt

et al. 2000

Field Analytical Chem & Tech

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An ion mobility spectrometer (IMS) equipped with a 10.6 eV low‐pressure gas‐discharge lamp usually used in photoionization detectors for gas chromatographic applications was developed for the continuous detection of benzene, toluene, and m‐xylene. To improve the resolution of the IMS for single substances a customized IMS with a doubled drift tube length was built. The responses of both IMS (drift tube lengths of 6 and 12 cm) to the compounds selected were determined and compared. The advantages of the combination of multi‐capillary columns with IMS are discussed with the aim of achieving further enhancements to the resolution of the instrument. This coupling leads to a significant increase in the scope of application of ion mobility spectrometry for environmental applications. The influence of intermolecular charge‐transfer reactions on the peak can be reduced and more complex matrices considered. The presented three‐dimensional correlation supports the interpretation of the spectra acquired from the mixtures. © 2000 John Wiley & Sons, Inc. Field Analyt Chem Technol 4: 157–169, 2000

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Section: Introductionmentioning

confidence: 99%

Quantitative analysis of benzene, toluene, and m‐xylene with the use of a UV–ion mobility spectrometer

Sielemann

Baumbach

Schmidt

et al. 2000

Field Analytical Chem & Tech

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“…Recently, a multicapillary (MC) column (a bundle of 919 40-μm capillaries) became commercially available (Alltech, Deerfield, IL) in the form of a 1-m helix . The MC column was shown to preserve the advantages of both packed and capillary columns while eliminating their drawbacks , and turned out to be an attractive tool for GC analysis of organohalogen compounds ,, and for time-resolved introduction of organometallic compounds in atomic spectrometry. − Baseline separations could be achieved within a fraction (one-tenth) of the time required in capillary GC. They were reached in the isothermal mode that allowed some reduction of the oven size and increased the sample throughput.…”

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confidence: 99%

Species-Selective Analysis by Microcolumn Multicapillary Gas Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection

Rodrı́guez

Mounicou²,

Łobiński³

et al. 1999

Anal. Chem.

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A glass rod (5-20 cm long, 2 mm o.d.) containing more than 1200 parallel microchannels (< 40 microns i.d.) was converted into a high-resolution (> 100 theoretical plates cm-1) GC column by coating the inside of each channel in a way that compensated for the dispersion of the channel inner diameter. The columns were evaluated for the separation of mixtures of several organometallic (Hg, Sn, Pb) compounds prior to on-line sensitive metalselective detection by ICPMS. Chromatographic separation conditions were optimized to enable a rapid (within a maximum 30 s) multielemental speciation analysis. Absolute detection limits were 0.1 pg for Hg, 0.05 pg for Sn, and 0.03 pg for Pb using the carrier gas flows of approximately 200 mL min-1. The microcolumn multicapillary GC/ICPMS developed was applied to the analysis of a number of environmental samples. The results were validated with certified reference materials for tin (BCR477, PACS-2) and mercury (DORM-1, TORT-1).

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“…For MCCs, which are composed of a large number of parallel glass capillaries (~1000), nonpolar OV-5 (5% diphenyl, 95% dimethylpolysiloxane) was used [ 78 , 99 ]. Compared to the ordinary CC, MCCs allow the separation to be carried out at an elevated speed and can be operated at increased carrier gas flows, which may pose an advantage for IMS analysis [ 100 ]. However, Garrido-Delgado and coworkers obtained the better predictive accuracy for the classification ( k NN classifier with k = 3) between different qualities of olive oil (EVOO, OO, and LVOO), when CC-IMS (83%) versus MCC-IMS (79%) was employed for the separation of the VOCs [ 32 ].…”

Section: Nts-workflowmentioning

confidence: 99%

Non-Targeted Screening Approaches for Profiling of Volatile Organic Compounds Based on Gas Chromatography-Ion Mobility Spectroscopy (GC-IMS) and Machine Learning

Capitain

Weller

2021

Molecules

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Due to its high sensitivity and resolving power, gas chromatography-ion mobility spectrometry (GC-IMS) is a powerful technique for the separation and sensitive detection of volatile organic compounds. It is a robust and easy-to-handle technique, which has recently gained attention for non-targeted screening (NTS) approaches. In this article, the general working principles of GC-IMS are presented. Next, the workflow for NTS using GC-IMS is described, including data acquisition, data processing and model building, model interpretation and complementary data analysis. A detailed overview of recent studies for NTS using GC-IMS is included, including several examples which have demonstrated GC-IMS to be an effective technique for various classification and quantification tasks. Lastly, a comparison of targeted and non-targeted strategies using GC-IMS are provided, highlighting the potential of GC-IMS in combination with NTS.

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Exploration of a Multicapillary Column for Use in Elevated Speed Gas Chromatography

Cited by 39 publications

References 26 publications

Quantitative analysis of benzene, toluene, and m‐xylene with the use of a UV–ion mobility spectrometer

Quantitative analysis of benzene, toluene, and m‐xylene with the use of a UV–ion mobility spectrometer

Species-Selective Analysis by Microcolumn Multicapillary Gas Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection

Non-Targeted Screening Approaches for Profiling of Volatile Organic Compounds Based on Gas Chromatography-Ion Mobility Spectroscopy (GC-IMS) and Machine Learning

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