“…However, though numerous studies and reviews have been published, as of recently, for the promotion of honey as more than a naturally occurring edible substance with a potential as a novel nutraceutical, the material is not without its own inherent limitations—especially within clinical settings. Some of the main limitations that clinical application of honey’s inherent properties may face include: variability in its composition, highlighting that, although honey is composed of many beneficial and exploitable compounds, without strict, precise, and accurate standardization of different honey types, any therapeutic properties may vary between different geographical samples of honey or even samples of the same geographical type of honey harvested from different points in a particular season or the year; and processing methods, namely illustrating the various commercial processes that honey may pass through, such as filtration, pasteurization, etc., that may negatively impact the therapeutic properties of heat-sensitive compounds within honey, such as enzymes, phenols, peptides, and vitamins, and, thus, its therapeutic potential would be affected [ 62 ].…”