Exploiting nanotechnology to target cancer

Sengupta, Shiladitya; Sasisekharan, Ram

doi:10.1038/sj.bjc.6603707

Cited by 84 publications

(73 citation statements)

References 27 publications

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“…Meanwhile, metallic (e.g., gold) or metal oxide (e.g., iron oxide) nanoparticles have recently demonstrated a reasonable therapeutic efficacy, selectivity, tumor affinity, and concomitant in vivo tolerance in cancer therapy [32]- [37]. The treatments are based on targeted delivery of the functionalized (e.g., using glucoproteins) nanoparticles to the tumor-affected areas and using either a brachytherapeutic or hyperthermal/photothermal treatment.…”

Section: Interaction Of Nanoparticles With Cellsmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

107

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To cite this version:M G Kong, M Keidar, K Ostrikov. Plasmas meet nanoparticleswhere synergies can advance the frontier of medicine. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (17) AbstractNanoparticles and low-temperature plasmas have been developed, independently and often along different routes, to tackle the same set of challenges in biomedicine. There are intriguing similarities and contrasts in their interactions with cells and living tissues, and these are reflected directly in the characteristics and scope of their intended therapeutic solutions, in particular their chemical reactivity, selectivity against pathogens and cancer cells, safety to healthy cells and tissues, and targeted delivery to diseased tissues. Time has come to ask the inevitable question of possible plasma-nanoparticle synergy and the related benefits to the development of effective, selective, and safe therapies for modern medicine. This perspective article offers a detailed review of the strengths and weakenesses of nanomedicine and plasma medicine as a stand-alone technology, and then provides a critical analysis of some of the major opportunities enabled by synergising the nanotechnology and the plasma technology. It is shown that the plasma-nanoparticle synergy is best captured through the plasma nanotechnology and its benefits for medicine are highly promising.

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Section: Interaction Of Nanoparticles With Cellsmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

107

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“…This superparamagnetism characteristic is unique to NPs (Schmidt, 2007). SPIONs have been used for both therapeutic and imaging purposes in cancer therapy (Sengupta & Sasisekharan, 2007;Ruoslahti et al, 2010).…”

Section: Magnetic-responsive Polymersmentioning

confidence: 99%

Classification of stimuli–responsive polymers as anticancer drug delivery systems

et al. 2014

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Although several anticancer drugs have been introduced as chemotherapeutic agents, the effective treatment of cancer remains a challenge. Major limitations in the application of anticancer drugs include their nonspecificity, wide biodistribution, short half-life, low concentration in tumor tissue and systemic toxicity. Drug delivery to the tumor site has become feasible in recent years, and recent advances in the development of new drug delivery systems for controlled drug release in tumor tissues with reduced side effects show great promise. In this field, the use of biodegradable polymers as drug carriers has attracted the most attention. However, drug release is still difficult to control even when a polymeric drug carrier is used. The design of pharmaceutical polymers that respond to external stimuli (known as stimuli-responsive polymers) such as temperature, pH, electric or magnetic field, enzymes, ultrasound waves, etc. appears to be a successful approach. In these systems, drug release is triggered by different stimuli. The purpose of this review is to summarize different types of polymeric drug carriers and stimuli, in addition to the combination use of stimuli in order to achieve a better controlled drug release, and it discusses their potential strengths and applications. A survey of the recent literature on various stimuli-responsive drug delivery systems is also provided and perspectives on possible future developments in controlled drug release at tumor site have been discussed.

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“…Nowadays, much attention is paid to QDs application in oncology, namely, cancer diagnostics and treatment [1]. The QDs application for finding and visualization of a tumor is based on their ability to be accumulated in a spread vascular system of a tumor when injected into a body [2]. Nanovalues of sizes, narrow fluorescence peaks high-fluorescence intensity being several tens greater than that of organic fluorophores traditionally used for visualization of cell inner compartments, are the useful specifications of the quantum dots.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Toxicity of Cdse/Cds/Zns/S,S-Dihydrolipoic Acid/Polyacrylic Acid Quantum Dots at Danio rerio Embryos and Larvae

Zolotarev

Kashirtseva

Mishin³

et al. 2012

ISRN Nanotechnology

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Quantum dots (QDs) are nanosized semiconductor crystals. They are currently applied in different science fields such as medicine, namely, cancer diagnostics and treatment. QD toxicity is caused by the toxicity of their components. In vivo application of QDs requires their toxicity assessment, so the purpose of this work has been the estimation of acute and chronic toxicity of the QDs at Danio rerio embryos and larvae, QDs being composed of CdSe/CdS/ZnS/S,S-dihydrolipoic acid/polyacrylic acid. We have found no QD acute toxicity during 48 hours of QDs action at the embryo up to the concentration of 185 µM Cd. QDs have been found to be toxic only at 5-7 days of action, it shows that QDs act accumulatively. Beside lethality, we have observed different larval development defects, that is, differently localized edemas, lag of development, tail curvature, and swimming bladder malformation. Our experimental data as well as literature data show that toxicity of the quantum dots at Danio rerio embryos and larvae is primarily caused by toxic action of Cd 2+ ion which arises from partial dissociation of CdSe and CdS molecules.

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Exploiting nanotechnology to target cancer

Cited by 84 publications

References 27 publications

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Classification of stimuli–responsive polymers as anticancer drug delivery systems

Assessment of Toxicity of Cdse/Cds/Zns/S,S-Dihydrolipoic Acid/Polyacrylic Acid Quantum Dots at Danio rerio Embryos and Larvae

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