Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders

Roy, Bhaskar; Yoshino, Yuta; Allen, Lauren; Prall, Kevin; Schell, Grant; Dwivedi, Yogesh K.

doi:10.1007/s40291-020-00464-9

Cited by 54 publications

(46 citation statements)

References 121 publications

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“…MicroRNAs regulate mRNAs at the post-transcriptional level and therefore affecting protein translation [19]. Changed miRNA expression patterns epigenetically affect almost every aspect of CNS function (i.e., in neurogenesis, synaptogenesis and neuronal migration) and its development [20][21][22]. For instance, miR-532, is reliably expressed in the human brain, localized as distinct granules in distal axons and growth cones, and proposed to play a role in axon growth and guidance [23].…”

Section: Discussionmentioning

confidence: 99%

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Identification of microRNAs Associated With Human Fragile X Syndrome Using Next Generation Sequencing

Anvari¹,

Vasei²,

Najmabadi³

et al. 2021

Preprint

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Fragile X syndrome (FXS) is caused by a mutation in the FMR1 gene which can lead to a loss or shortage of the FMR1 protein. This protein interacts with specific miRNAs, and a change can cause a range of neurological disorders. Therefore, miRNAs could act as a novel class of potential biomarkers for common CNS diseases. The aim of this study was to test this theory by exploring the expression profiles of various miRNAs in Iranian FXS patients using deep sequencing-based technologies, and validate the miRNAs affecting expression of the FMR1 gene. Blood samples were taken from 15 patients with FXS (9 males, 6 females) and 12 controls. 25 miRNAs were differentially expressed in individuals with FXS compared to controls. Levels of 9 miRNAs were found to be significantly changed (3 upregulated and 6 downregulated). In FXS patients, the levels of hsa-miR-532-5p, hsa-miR-652-3p and hsa-miR-4797-3p were significantly upregulated while levels of hsa-miR-191-5p, hsa-miR-181-5p, hsa-miR-26a-5p, hsa-miR-30e-5p, hsa-miR-186-5p, and hsa-miR-4797-5p exhibited significant downregulation; and these dysregulations were confirmed by RT‐qPCR. This study present altered miRNA expression in blood samples from FXS patients, which could be used for diagnostic, prognostic, and treatment purposes. Larger studies are required to confirm these preliminary results.

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Section: Discussionmentioning

confidence: 99%

“…Third, we examined miRNA expression changes in non-neuronal cells due to the fact that neuronal tissue is not easily accessible. However, it has been shown that miRNA expression changes in the peripheral circulation are highly correlated with those of neuronal tissue from patients with various neuropsychiatric disorders [20].…”

Section: Discussionmentioning

confidence: 99%

Identification of microRNAs Associated With Human Fragile X Syndrome Using Next Generation Sequencing

Anvari¹,

Vasei²,

Najmabadi³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Through those mechanisms one miRNA molecule can influence expression of hundreds of target genes, thus, together they have an enormous impact on transcriptome and proteome [ 10 ]. It is then not surprising that changes of their expression have been found to be involved in etiopathogenesis of many disorders, including cancers, diabetes [ 126 ], neurodegenerations and neuropsychiatric ones [ 127 , 128 , 129 ]. This is also true for depression, where in the last decade several dozen miRNAs have been found to be deregulated.…”

Section: Mirnamentioning

confidence: 99%

The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder

Czarny

Białek

Ziółkowska

et al. 2021

JPM

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Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are able to influence the severity of the disease and the outcome of the therapy. This article summarizes the most recent literature data on this topic, i.e., usage of histone deacetylases as therapeutic agents with an antidepressant effect and miRNAs or lncRNAs as markers of depression. Due to the noteworthy potential of the role of epigenetics in MDD diagnostics and therapy, we have gathered the most relevant data in this area.

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“…Because of the stability, non-invasiveness, and sensitivity of miRNAs, the abnormal expression of miRNAs might be useful for disease diagnosis [63][64][65]. The serum levels of miR-16-5p, miR-23-3p, miR125b-5p, miR-126-3p, miRN-146α-5p, and miR-223-3p in RA patients were identified as potential novel biomarkers for predicting and monitoring therapy outcomes to anti-TNFα/DMARD combination therapies [66].…”

Section: Intestinal Microbiome Dysbiosis and Abnormal Mirna Profiles Accompany Ra Developmentmentioning

confidence: 99%

Microbiome–miRNA interactions in the progress from undifferentiated arthritis to rheumatoid arthritis: evidence, hypotheses, and opportunities

et al. 2021

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The human microbiome has attracted attention for its potential utility in precision medicine. Increasingly, more researchers are recognizing changes in intestinal microbiome can upset the balance between pro- and anti-inflammatory factors of host immune system, potentially contributing to arthritis immunopathogenesis. Patients who develop rheumatoid arthritis from undifferentiated arthritis can face multiple irreversible joint lesions and even deformities. Strategies for identifying undifferentiated arthritis patients who have a tendency to develop rheumatoid arthritis and interventions to prevent rheumatoid arthritis development are urgently needed. Intestinal microbiome dysbiosis and shifts in the miRNA profile affect undifferentiated arthritis progression, and may play an important role in rheumatoid arthritis pathophysiologic process via stimulating inflammatory cytokines and disturbing host and microbial metabolic functions. However, a causal relationship between microbiome–miRNA interactions and rheumatoid arthritis development from undifferentiated arthritis has not been uncovered yet. Changes in the intestinal microbiome and miRNA profiles of undifferentiated arthritis patients with different disease outcomes should be studied together to uncover the role of the intestinal microbiome in rheumatoid arthritis development and to identify potential prognostic indicators of rheumatoid arthritis in undifferentiated arthritis patients. Herein, we discuss the possibility of microbiome–miRNA interactions contributing to rheumatoid arthritis development and describe the gaps in knowledge regarding their influence on undifferentiated arthritis prognosis that should be addressed by future studies.

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Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders

Cited by 54 publications

References 121 publications

Identification of microRNAs Associated With Human Fragile X Syndrome Using Next Generation Sequencing

Identification of microRNAs Associated With Human Fragile X Syndrome Using Next Generation Sequencing

The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder

Microbiome–miRNA interactions in the progress from undifferentiated arthritis to rheumatoid arthritis: evidence, hypotheses, and opportunities

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