The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder

Czarny, Piotr; Białek, Katarzyna; Ziółkowska, Sylwia; Strycharz, Justyna; Barszczewska, Gabriela; Śliwiński, Tomasz

doi:10.3390/jpm11030167

Cited by 17 publications

(6 citation statements)

References 212 publications

(153 reference statements)

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“…DNA methylation is one of the most widely studied epigenetic mechanisms regulating gene expression and mediated by DNA methyltransferases (DNMTs), among which DNMT1 mediates hemi-methylation and DNMT3A and DNMT3B were responsible for de novo methylation [ 21 ]. DNA methylation in CpG-rich promoter regions is linked to gene repression and DNA methylation within gene bodies is associated with gene activation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism

Luo

Wang

et al. 2021

Clin Epigenet

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Background Type 2 diabetes mellitus (T2DM) and hypothyroidism are two common endocrine diseases and the phenomenon that the prevalence of diabetes-related hypothyroidism shows a significant upward trend deserves further attention, but the specific pathogenesis is not yet clear. The study aimed to explore the molecular mechanisms on DNA methylation regulating gene expression and participating in diabetes-related hypothyroidism through genome-wide DNA methylation and RNA sequencing. Results The prevalence of hypothyroidism in T2DM patients was significantly higher than that in patients without T2DM (P = 0.018). Meanwhile, high TSH and low T3 and T4 levels were detected in diabetic mice. Low T3 and T4 levels were detected in Nthy-ori3-1 cells incubated in high-glucose medium. Differentially expressed genes (DEGs) and differentially methylated regions (DMRs) were detected by RNA sequencing and reduced representation bisulfite sequencing in Nthy-ori3-1 cells cultured in high-glucose and normal medium. Functional enrichment analyses reveled that DMRs and DEGs were related to significant pathways including Ras, Wnt and MAPK pathways. Conclusions We observed the potential connection between T2DM and hypothyroidism. This study was the first one carrying out DNA methylation and gene expression profiles to explore epigenetic modification in diabetes-related hypothyroidism, which provided information for the detailed study of the molecular mechanism in diabetes-related hypothyroidism.

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Section: Discussionmentioning

confidence: 99%

Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism

Luo

Wang

et al. 2021

Clin Epigenet

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“…), the namely epigenetic mechanism ( Alshaya, 2022 ). The current research mainly involves three pathways: post-translational histone modifications, RNA interference, and DNA methylation ( Czarny et al, 2021 ).…”

Section: Potential Mechanism Of Gut Microbiota Involved In the Regula...mentioning

confidence: 99%

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

Han

Wang²,

Han³

et al. 2022

Front. Neurosci.

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The relationship between gut microbiota (GM) and mental health is one of the focuses of psychobiology research. In recent years, the microbial-gut-brain axis (MGBA) concept has gradually formed about this bidirectional communication between gut and brain. But how the GM is involved in regulating brain function and how they affect emotional disorders these mechanisms are tenuous and limited to animal research, and often controversial. Therefore, in this review, we attempt to summarize and categorize the latest advances in current research on the mechanisms of GM and depression to provide valid information for future diagnoses and therapy of mental disorders. Finally, we introduced some antidepressant regimens that can help restore gut dysbiosis, including classic antidepressants, Chinese materia medica (CMM), diet, and exogenous strains. These studies provide further insight into GM’s role and potential pathways in emotion-related diseases, which holds essential possible clinical outcomes for people with depression or related psychiatric disorders. Future research should focus on clarifying the causal role of GM in disease and developing microbial targets, applying these findings to the prevention and treatment of depression.

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“…Methylation refers to the regulation of gene expression by a family of DNA methyltransferases via the addition of a methyl group to the 5-carbon of the cytosine base. Studies have demonstrated that the abnormal methylation of genes can result in disease progression, and that relatively stable methylation patterns can act as biomarkers for the diagnosis and treatment of depression [ 8 , 9 ]. These studies focused on genes that had previously been implicated in the pathophysiology of depressive disorder and found to be frequently methylated.…”

Section: Introductionmentioning

confidence: 99%

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

Tao

Zhang

et al. 2022

BMC Psychiatry

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Objective We aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment. Methods After recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis. Results The gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress. Conclusions Our results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression. Trial registration ChiCTR, ChiCTR2000033402, 31/05/2020, http://www.chictr.org.cn/index.aspx

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The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder

Cited by 17 publications

References 212 publications

Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism

Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism

Reviewing the role of gut microbiota in the pathogenesis of depression and exploring new therapeutic options

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

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