Exploitation of shifts of eutectic compositions in crystallization-based enantioseparation

Lorenz, Heike; Lê, Minh Tâm; Kaemmerer, Henning; Buchholz, Hannes Konrad; Seidel‐Morgenstern, Andreas

doi:10.1016/j.cherd.2013.08.013

Cited by 11 publications

(16 citation statements)

References 22 publications

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“…A detailed explanation of basic principles of the ternary phase diagram and their relevance for enantioseparation purposes has been presented. Similarly derived equilibrium-based approaches were already successful to isolate pure enantiomers of other chiral systems [26,27]. Given the importance of phase diagrams in numerous research fields, the guidelines provided here offer a strong basis for other applications.…”

Section: Discussionmentioning

confidence: 95%

Exploiting Ternary Solubility Phase Diagrams for Resolution of Enantiomers: An Instructive Example

2020

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Ternary phase diagrams are essential research tools in several scientific fields. They provide fundamental understanding and guidance in designing separation experiments. While their utility and relevance is undisputed in the chemical and chemical engineering community, yet much progress remains to be done in understanding and exploiting ternary phase diagrams for crystallization-based chiral separation purposes. A guide in the interpretation of the ternary solubility phase diagram of a chiral molecule to design the separation of its enantiomers is provided. On the basis of the discussion of fundamental relationships in the phase diagram, basic enantioseparation experiments are performed for D-/L-methionine in water exploiting the characteristic shift of the eutectic composition in the chiral system. The rational approach followed in separation process design is described together with the experimental procedures applied and the results obtained.

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Section: Discussionmentioning

confidence: 95%

Exploiting Ternary Solubility Phase Diagrams for Resolution of Enantiomers: An Instructive Example

2020

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“…B., wenn sich die eutektische Zusammensetzung im chiralen System mit der Temperatur und/oder der Lçsungsmittelzu-sammensetzung ändert. [151,152] Zusammenfassend ist abzuleiten, dass (mit Ausnahme der Bevorzugten Kristallisation von Konglomeraten) kristallisationsbasierte Racematspaltungen für gewçhnlich eine gewisse Enantiomerenanreicherung erfordern, die z. B. in einem integrierten Verfahren über eine partiell selektive Synthese oder einen anderen alternativen Trennschritt bereitgestellt werden kann.…”

Section: Angewandte Chemieunclassified

“…[191] Die temperaturabhängige Verschiebung der eutektischen Zusammensetzung in chiralen Systemen wurde genutzt, um ein alternatives zweistufiges (Zwei-Schritt-)Verfahren zur Enantiomerentrennung vorzuschlagen. Das Prinzip ist in [151] Im nächsten Abschnitt werden Prinzip und Verfahrenskonzepte der präparativen Chromatographie als vielseitige und häufig eingesetzte Methode zur Enantiomerentrennung vorgestellt.…”

Section: Methionin Und Trçgersche Baseunclassified

Verfahren zur Enantiomerentrennung

Lorenz

Seidel‐Morgenstern

2014

Angewandte Chemie

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Die Verfügbarkeit reiner Enantiomere ist von steigender Bedeutung für die pharmazeutische Industrie sowie auch für die Agrochemie und Biotechnologie. Generell gibt es zwei konkurrierende Ansätze zur Gewinnung von reinen Enantiomeren. Der “chirale” Ansatz basiert auf der Entwicklung einer asymmetrischen Synthese, die selektiv eines der Enantiomere liefert. Der “racemische” Ansatz basiert auf der Trennung eines Gemischs der beiden Enantiomere, wobei hier in den letzten Jahren bemerkenswerte Fortschritte erzielt werden konnten. Dieser Aufsatz fokussiert insbesondere auf enantioselektive Kristallisationsprozesse und präparative Chromatographie, einschließlich hybrider Trennprozesse und der zusätzlichen Integration von Racemisierungsschritten. Zur Illustration dienen mehrere in unserem Arbeitskreis untersuchte Trennungen.

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“…In order to design chemical processes, crystallization and separation operations, the concept of an equilibrium phase diagram is required [34,35]. Thus, many articles, including phase diagram process, have been published concerning the salt extraction from mixtures of salt lakes, natural brines, seawater and wastewater [36,37].…”

Section: Introductionmentioning

confidence: 99%

Continuous and simultaneous conversion of Moroccan phosphogypsum waste to Na2SO4, and K2SO4 using the quaternary system Na+, K+ // Cl-, SO42- - H2O at 25°C

Laaboubi

Bouargane

Pérez-Moreno

et al. 2022

Preprint

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In this present work, the transformation of the Moroccan phosphogypsum (PG) waste, considered as a potential source of sulfate, into potassium sulfate compound could help to reduce environmental impact and to create a new value chain for the phosphate industry. Generally, solidliquid equilibria are frequently applied in chemical industries. They are a valuable aid for visualizing the precipitation, separation, purification of a solid phase and pathways through which crystallization can proceed. The aim of this process is to produce potassium sulfate, a high-value fertilizer, from sulfate solutions obtained after dissolving Moroccan phosphogypsum in NaOH medium. The quaternary phase diagram Na + , K + // Cl - , SO 4 2- - H 2 O at 25°C was especially used to determine the operating conditions and the design of a crystallization process during the phosphogypsum conversion into potassium sulfate. The Jänecke representation of this system enables the determination of the optimal trajectory in the phase diagram for the double decomposition reaction. X-ray Fluorescent (XRF) and X-ray diffraction (XRD) techniques were conducted to identify the crystalline phases formed. The results of this study could be contributing to the development of a sustainable valorization of Moroccan phosphogypsum. Furthermore, the potassium sulfate represents a good alternative to potassium chloride for chloride-sensitive crops.

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Exploitation of shifts of eutectic compositions in crystallization-based enantioseparation

Cited by 11 publications

References 22 publications

Exploiting Ternary Solubility Phase Diagrams for Resolution of Enantiomers: An Instructive Example

Exploiting Ternary Solubility Phase Diagrams for Resolution of Enantiomers: An Instructive Example

Verfahren zur Enantiomerentrennung

Continuous and simultaneous conversion of Moroccan phosphogypsum waste to Na2SO4, and K2SO4 using the quaternary system Na+, K+ // Cl-, SO42- - H2O at 25°C

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