Explanatory Notes – General

Wittekind, Christian; Brierley, James D.; Lee, Anne; Eycken, E. Van

doi:10.1002/9780471420194.tnms01.pub4

Cited by 4 publications

(5 citation statements)

References 57 publications

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“…Therefore, in extreme cases, many general hospitals may be able to replace the pathological invasive size with the solid CT size after histological diagnosis and pathological diagnosis of pleural or chest wall invasion. This is not an impractical idea and is actually stated in the UICC TNM supplement that “in cases of discrepancies of clinically and pathologically detected tumor size the clinical measurement should be used also for the pathological T classification” [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter

Funai

Kawase

Mizuno

et al. 2020

Cancers

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The biggest change in the 8th edition of the tumor, lymph node, and metastasis (TNM) classification is the recommendation of the solid component diameter and invasive size for determining the clinical and pathological T-factor, respectively. Here, we validated new proposals for the Lung Cancer TNM classification’s revision and compared clinical and pathological T-stages. We retrospectively analyzed 177 cases of non-small cell lung cancers without lymph node metastasis, and involving complete resection, that occurred in our department between January 2017 and March 2019. We reviewed the overall tumor diameter, solid component diameter, and clinical T-factor on computed tomography (CT), and the pathological tumor diameter, pathological invasion diameter, pathological T-factor, and prognosis. The difference between the pathological invasive size and solid size on CT was within 5 mm in 99 cases (56%). At a two-year recurrence-free survival rate, the clinical T-stage demonstrated a better prognostic outcome than the pathological T-stage. Despite including the benign findings, the solid component diameter was better correlated with prognosis than the invasive size. Therefore, in cases of discrepancies of clinically and pathologically detected tumor size, the solid CT size should also be used for the pathological T classification.

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Section: Discussionmentioning

confidence: 99%

8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter

Funai

Kawase

Mizuno

et al. 2020

Cancers

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“…Between 2017 and 2020, three different studies confirmed the prognostic value of the IASLC definition [ 17 , 18 , 19 ].…”

Section: Port After Complete Resectionmentioning

confidence: 99%

“…The International Association for the Study of Lung Cancer (IASLC) staging committee defined complete resection as follows: microscopically free resection margins (R0), systematic nodal dissection or lobe-specific systematic nodal dissection, lack of extracapsular nodal extension (ENE) and negativity for tumor infestation at the highest mediastinal node removed [ 17 , 18 , 19 ].…”

Section: Port After Complete Resectionmentioning

confidence: 99%

Role of Adjuvant Radiotherapy in Non-Small Cell Lung Cancer—A Review

Süveg

Plaßwilm

Iseli

et al. 2022

Cancers

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Background: For patients with completely resected non-small cell lung cancer (NSCLC) with ipsilateral mediastinal lymph node involvement (pN2), the administration of adjuvant chemotherapy is the standard of care. The role of postoperative radiation therapy (PORT) is controversial. Methods: We describe the current literature focusing on the role of PORT in completely resected NSCLC patients with pN2 involvement and reflect on its role in current guidelines. Results: Based on the results of the recent Lung ART and PORT-C trials, the authors conclude that PORT cannot be generally recommended for all resected pN2 NSCLC patients. A substantial decrease in the locoregional relapse rate without translating into a survival benefit suggests that some patients with risk factors might benefit from PORT. This must be balanced against the risk of cardiopulmonary toxicity with potentially associated mortality. Lung ART has already changed the decision making for the use of PORT in daily practice for many European lung cancer experts, with lower rates of recommendations for PORT overall. Conclusions: PORT is still used, albeit decreasingly, for completely resected NSCLC with pN2 involvement. High-level evidence for its routine use is lacking. Further analyses are required to identify patients who would potentially benefit from PORT.

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“…The reference document TNM Supplement: A commentary on uniform use, 5th edition (C Wittekind et al editors) may be of assistance when staging (83).…”

Section: Provisional Pathologic Staging (Core)mentioning

confidence: 99%

Data Set for the Reporting of Carcinomas of the Vulva: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

Hoang

Webster

Bosse

et al. 2022

International Journal of Gynecological Pathology

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A cogent and comprehensive pathologic report is essential for optimal patient management, cancer staging, and prognostication. This article details the International Collaboration on Cancer Reporting (ICCR) process and the development of the vulval carcinoma reporting data set. It describes the "core" and "noncore" elements to be included in pathology reports for vulval carcinoma, inclusive of clinical, macroscopic, microscopic, and ancillary testing considerations. It provides definitions and commentary for the evidence and/or consensus-based deliberations for each element included in the data set. The commentary also discusses controversial issues, such as p16/human papillomavirus testing, tumor grading and measurements, as well as elements that show promise and warrant further evidence-based study. A summary and discussion of the updated vulval cancer staging system by the International Federation of Obstetricians and Gynaecologists (FIGO) in 2021 is also provided. We hope the widespread implementation of this data set will facilitate consistent and accurate reporting, data collection, comparison of epidemiological and pathologic parameters between different populations, facilitate research, and serve as a platform to improve patient outcomes.

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Explanatory Notes – General

Cited by 4 publications

References 57 publications

8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter

8th Edition Tumor, Node, and Metastasis T-Stage Prognosis Discrepancies: Solid Component Diameter Predicts Prognosis Better than Invasive Component Diameter

Role of Adjuvant Radiotherapy in Non-Small Cell Lung Cancer—A Review

Data Set for the Reporting of Carcinomas of the Vulva: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

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