Explaining heterogeneity in disability with major depressive disorder: Effects of personal and environmental characteristics

Verboom, Charlotte Eline; Sentse, Miranda; Sijtsema, Jelle J.; Nolen, Willem A.; Ormel, Johan; Penninx, Brenda W. J. H.

doi:10.1016/j.jad.2011.01.016

Cited by 28 publications

(22 citation statements)

References 43 publications

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“…In addition, low conscientiousness predicted greater functional impairment over a prolonged period of time in both persons with subthreshold disorder and controls. This finding is in line with Verboom et al, [13] who found that low conscientiousness was associated with greater functional impairment in full-syndromal MDD. High levels of conscientiousness have been found to predict active coping strategies, [37] health-related behavior, and beneficial social environmental factors, such as higher socioeconomic status, [38] all of which may boost functioning in daily life.…”

Section: Discussionsupporting

confidence: 91%

Course and Risk Factors of Functional Impairment in Subthreshold Depression and Anxiety

et al. 2012

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Background: Although persons with subthreshold depression or anxiety are known to be at risk for full-syndromal disorders, little is known about their functioning over time. In this study, we investigate the functional impairment of persons with subthreshold depression or anxiety over time, compared to that of controls. Furthermore, we evaluate which illness, personal, and environmental risk factors influence its course. Methods: Data come from the Netherlands Study of Depression and Anxiety (N = 1,266, aged 18-65). Linear mixed models were used to identify predictors of functional impairment at baseline, 1-, and 2-year follow-up. Risk factors were evaluated in their overall effect on functioning and on change in functioning over time, and whether they differed for respondents with and without subthreshold depression or anxiety. Results: Functional impairment in subthreshold respondents improved over time, but remained much higher than in controls. Prior anxiety disorder, high neuroticism, low conscientiousness, more somatic conditions, and more childhood trauma all predicted greater functional impairment. Older age predicted lower functioning only in subthreshold respondents, while the effect of neuroticism was stronger in subthreshold respondents relative to controls. Conclusions: Functional impairment in subthreshold respondents improved over time, but remained elevated compared to that of controls. Given continuously elevated levels of impairment, preventive interventions should be focused on persons with subthreshold symptoms; in particular those with prior anxiety disorder, high neuroticism, low conscientiousness, somatic conditions, or childhood trauma. Depression and Anxiety 30:386-394, 2013.C 2012 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Course and Risk Factors of Functional Impairment in Subthreshold Depression and Anxiety

et al. 2012

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“…Although functional impairment is a required dimension of DSM‐IV psychiatric diagnoses, there are also individual differences in the extent of impairment, even for a given level of symptom severity [Eack and Newhill, ; Priebe et al, ; Verboom et al, ]. This evidence coincides with clinical observations that some patients are nearly incapacitated by relatively mild symptoms of psychiatric disorders while other patients are able to sustain activities of daily living despite moderate to severe psychiatric symptoms.…”

Section: Introductionmentioning

confidence: 56%

Genetic predictors of risk and resilience in psychiatric disorders: A cross‐disorder genome‐wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia

McGrath

Cornelis²,

Lee

et al. 2013

American J of Med Genetics Pt B

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Functional impairment is one of the most enduring, intractable consequences of psychiatric disorders and is both familial and heritable. Previous studies have suggested that variation in functional impairment can be independent of symptom severity. Here we report the first genome-wide association study (GWAS) of functional impairment in the context of major mental illness. Participants of European-American descent (N=2,246) were included from three large treatment studies of bipolar disorder (STEP-BD) (N=765), major depressive disorder (STAR*D) (N=1091), and schizophrenia (CATIE) (N=390). At study entry, participants completed the SF-12, a widely-used measure of health-related quality of life. We performed a GWAS and pathway analysis of the mental and physical components of health-related quality of life across diagnosis (~1.6 million single nucleotide polymorphisms), adjusting for psychiatric symptom severity. Psychiatric symptom severity was a significant predictor of functional impairment, but it accounted for less than one-third of the variance across disorders. After controlling for diagnostic category and symptom severity, the strongest evidence of genetic association was between variants in ADAMTS16 and physical functioning (p=5.87 × 10−8). Pathway analysis did not indicate significant enrichment after correction for gene clustering and multiple testing. This study illustrates a phenotypic framework for examining genetic contributions to functional impairment across psychiatric disorders.

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“…In these studies personality characteristics (neuroticism, openness and contentiousness) were associated with impaired work functioning (Verboom et al, 2011) and coping (believing that depressive symptoms are caused by factors outside of their control) with impaired general functioning (Brown et al, 2007). Personality characteristics (neuroticism, external locus of control and lower self-esteem) were also more important than having a mental disorder (mood disorder, anxiety disorder and substance-use disorder) in predicting work functioning in a general Dutch population (Michon et al, 2008).…”

Section: Predictorsmentioning

confidence: 99%

Predictors of impaired work functioning in employees with major depression in remission

Vries

Koeter

Nieuwenhuijsen

et al. 2015

Journal of Affective Disorders

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Explaining heterogeneity in disability with major depressive disorder: Effects of personal and environmental characteristics

Cited by 28 publications

References 43 publications

Course and Risk Factors of Functional Impairment in Subthreshold Depression and Anxiety

Course and Risk Factors of Functional Impairment in Subthreshold Depression and Anxiety

Genetic predictors of risk and resilience in psychiatric disorders: A cross‐disorder genome‐wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia

Predictors of impaired work functioning in employees with major depression in remission

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