Experimentelle Untersuchungen zur Spezifität der Sensibilisierung gegen Phenylhydroxylamin

Positive Skin Reaction Induced by 4,4′-Azoxybenzenedisulfonamide in Relationship to the Sulfanilamide Allergy

“…Further, our findings differ from those of Schwarz and Speck [8] in the im-portance of the sulfonamide group. The 4,4'-AZOBDSA appears to be reduced at the skin site into biotransformed intermedi ates which might combine irreversibly with tissue macromolecules, i.e., proteins, form ing thereby complete antigens.…”

“…As shown in table I, in both groups sen sitized with SA and 4-HABSA, positive eli- Table I reaction in group C. Schwarz and Speck [8] have reported that azoxybenzene was inac tive in guinea pigs sensitized to phenylhydroxylamine. Therefore, it is interesting that all animals used exhibited sensitivity reac tions 24-48 h after application of 4,4'-AZOBDSA to abdominal skin.…”

“…Thauer et al [11] have also reported that 4-HABSA may be formed by catalysis of washed rat liver microsomes, by the N4-hydroxylation of SA in the presence of NADPH and Oa. Schwarz and Speck [8] have further demonstrated a high degree of skin sensitivity to the hydroxylaminobenzene group in testing a number of compounds for cutaneous hypersensitivity. These include aniline, nitrobenzene, azoxybenzene, azobenzene, hydrazobenzene, p-, o-, and m-aminophenol, p-phenylenediamine, SA, 4-HABSA and 4-nitrosoben-zene.…”