Experimentelle Untersuchungen über die Manganpneumonie und ihre Beziehungen zur Thomasschlackenpneumonie

Supplement

“…Histological examinations of lung tissue of rabbits exposed to Mn02 via inhalation showed infiltration of leukocytes in the peripheral alveolar region within 19 days of exposure (36). In another experiment on mice by the same author, no pneumonic changes W,ere seen within 20 days after Mn02 exposure.…”

“…J6tten et al (36) exposed 32 rabbits to Mn02 dust 1 hlday for 39 days in the first of a set of experiments. No data were given on the aerosol concentration.…”

“…Results from experimental studies attempting to produce pneumonia in animals exposed to manganese are also contradictory. Jotten et al (36) showed that exposure to Mn02 dust, or to manganese as a 10 % part of Thomasslachen smoke, resulted in an increased mortality rate and typical pneumonialike changes in lung tissue of rabbits. In combined exposures to draft and pneumococci the effect was increased.…”

Manganese Pneumonitis

“…Jotten (1939), described the histological changes in rabbits' lungs after exposure to manganese dust as a severe bronchitis with bronchiolitic changes. No signs of croupous pneumonia were present and these authors described the cellular reaction as a leucocytic and partly lymphocytic infiltration.…”

“…of basic slag workers die of pneumonia, and a sudden death in an agricultural worker (Koch, 1942) who had been employed in spreading basic slag has been ascribed to broncho-pneumonia caused by slag. As Jotten and Reploh (1938) The present experiments were undertaken with the object of determining whether manganese causes an increase in susceptibility to the pneumococcus. For the investigation of the effect of manganese on the lungs a larger animal would have been chosen, but the histological effects were so uniform and so striking that a detailed description is warranted.…”