Experimentelle und klinische Studien zur Behandlung der postoperativen Tetanie mit A. T. 10

A Comparison of the Effects of A.T. 10 (Dihydrotachysterol) and Vitamin D on Calcium and Phosphorus Metabolism in Hypoparathyroidism

“…Holtz, Gissel, and Rossmann (7) studied the various derivatives of ergosterin. It was found (7,8) that upon irradiation of ergosterin with ultraviolet light one obtained the following substances: ergosterin, lumisterin, tachysterin, vitamin D, toxisterin, suprasterin I, and suprasterin II. Of these, tachysterin, vitamin D, and toxisterin contained the "Calcinosefaktor"; vitamin D alone, contained the antirachitic factor.…”

“…A method of standardizing the toxic effect of ergosterin derivatives has been worked out (7). The unit of toxicity is designated the " Toxische Grenzdosis " (T.G.)…”

Quantitative Studies Upon Some Blood Constituents of Helix Pomatia

“…Almost every month of the years 1933 to 1936 the blood of two lots of snails (10 to 12 animals each) was collected by puncture of the lateral vein. The following determinations were performed : dry substance by drying a sample at 100 C., total inorganic substances by incineration of dry substance, P according to Embden (1921), Ca according to Holtz (1934).…”

Incidence of dystrophies caused by fluorine in organs regulated by the parathyroid glands

“…Macroscopically such dental changes thus resemble those produced by a lowered function of the parathyroid glands, whether resulting from surgical damage or from chemical destruction. On the other hand, Smith et al (1935) and Smith (1936) demonstrated that mottled teeth, which are the result of decalcification produced by the destructive action of fluorine, cannot be prevented either by means of dietary improvement or by the addition of vitamins A, C or D. Yet, the facts that rickets is cured by vitamin D, and that tetany, even when resulting from damage done to the parathyroid glands in the course of strumectomy, is capable of being held in check by the administration of cod-liver oil or irradiated ergosterin, even without the addition of parathyroid extract (Holtz, 1933;Holtz, Gissel & Rossmann, 1934), or with its addition in small doses (Boothby, 1931(Boothby, , 1932Boothby, Haines & Pemberton, 1930, 1931Boothby & Woltman, 1935); these facts and several experiments based on the principle of substituting vitamin D for the parathyroid extract which has become deficient in parathyroidectomnized animals (Jones, 1926;Urechia & Popoviciu, 1928;Brougher, 1928;Shelling, 1930;Comel, 1930;Taylor, Weld, Branion & Kay, 1931;Spreter von Kreudenstein, 1937, 1938; all quoted by Thoma, 1941), would seem to indicate a similarity in the actions of vitamin D and the parathyroid hormone. Both regulate the calcium metabolism, and each of them is capable of replacing the other, should such a replacement become necessary as a result of its deficiency.…”