“…However, the different distribution in experimental amyloidosis may reflect the technique of the experiment rather than the nature of the degener ative process. When amyloidogenic agents are given orally, the lesions may be confined to the liver, as found by Murata and Yoshikawa (1927) who fed rabbits and mice with various forms of silicate. Using subcutaneous injections, short term experiments disclose in volvement of the spleen only.…”