Experimental Vitreous Syneresis

Intravitreal gas injection for the treatment of experimental vitreous hemorrhage in rabbits

“…New non-invasive approaches, based on a biomechanical alteration of the vitreous gel, hold promise, as already indicated for the use of hyaluronidase in non-clearing vitreous hemorrhage. 7 The induced vitreous liquefaction [8][9][10][11][12][13][14] and blood-retinal barrier breakdown 10,15,16 associated with the use of expansive gases in vivo have led the authors to consider its therapeutic use in experimental vitreous hemorrhage. The purpose of this study was to evaluate the effectiveness of a single injection of an expanding gas in the vitreous cavity in order to accelerate the clearance rate in experimental vitreous hemorrhage.…”

“…The gas bubble absorption causes rehydration, accompanied by extreme and irreversible liquefaction of the rabbit vitreous. [8][9][10][11][12][13][14] Although an expanding gas bubble cannot remove formed vitreous, it compresses the vitreous into a smaller fraction of the total cavity volume, thereby displacing the vitreous as a natural barrier to passive cell diffusion 25 and enabling red cell lysis and phagocytosis to occur. Indeed, studies have shown that hemorrhage into a space outside the formed vitreous or recurrent hemorrhage after vitrectomy clears more rapidly than hemorrhage into the vitreous gel.…”

Spectrum of morphological and visual changes due to vitreomacular interface disorders encountered in a large consecutive cohort of patients

“…[2][3][4][5] This gives rise to a hyper-reflective line anterior to the retinal surface visible on optical coherence tomography (OCT) scans, which is either not associated with any structural changes of the retinal parenchyma, so-called vitreomacular Adhesion (VMA) or VMT, where some effect of traction is visible. [6][7][8] The ease with which VMT can be diagnosed using OCT has enabled accurate selection of patients for therapeutic interventions with surgery or pharmacological vitreolysis and also enabled detailed studies on classification, staging, and further understanding of the natural history of VMT.…”

The Vitreous

“…When rabbit eyes with intravitreal C3F 8 were followed for 6 months, no liquefaction or vitreous detachment was present and the ultrastructural appearance of the vitreous was normal. However, Miller et al (1985) found that the expansion of intravitreal C3F 8 induced central vitreous synchisis. Biochemically, there is a loss of hyaluronic acid within the vitreous (Lincoff et aI, 1986b) and an increased protein content (Constable and Swann, 1971;Lincoff et aI, 1983).…”