The Vitreous

Sebag, J.

doi:10.1007/978-1-4613-8908-8

Cited by 82 publications

(10 citation statements)

References 164 publications

(290 reference statements)

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“…The interpretation of cellularity, cell types and cellular predominance can thus be difficult for cytopathologists without experience in ophthalmic pathology. For a long time, vitreous fluid has been deemed to be almost acellular and contain only a few resident cells called hyalocytes [1]. In our study, only 6 cases were acellular.…”

Section: Discussionmentioning

confidence: 50%

“…In our study, only 6 cases were acellular. Cells with the morphological characteristics of hyalocytes were observed in only 15 cases; these cells were preferentially located at the posterior vitreous cortex, belonged to the monocyte/macrophage family and had a fibroblast-like morphology [1]. Moreover, hyalocytes can be difficult to identify because their morphological description is mainly based on electron microscopy and due to a lack of specific antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…It has a role in maintaining the structural stability of the eye and retinal health [1]. Several afflictions may impair vision by damaging vitreous fluid transparency or vitreo/retinal interface integrity.…”

Section: Introductionmentioning

confidence: 99%

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Cytopathology of Vitreous Humor Samples in Routine Practice

Boulagnon-Rombi¹,

Ducasse

Patey³

et al. 2016

Acta Cytologica

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Objective: To describe findings in vitreous fluid samples in routine cytology practice. Study Design: The pathology archives from 1988 to 2008 at our institution were searched for vitreous samples. The slides were reviewed and clinical and follow-up information was obtained. Results: One hundred and eighty-two vitreous fluid samples from 166 patients were analyzed. Most of the samples had been collected for vitreous hemorrhage (75 cases). The second reason for vitreous sample cytological evaluation was an intraocular inflammatory process (55 cases). A specific cause of inflammation was found by combining clinical, microbiological and cytopathological findings in 19 cases, i.e. infection in 7, sarcoidosis in 3, retinal necrosis in 3, lens-induced endophthalmitis in 2, uveitis associated with systemic disease in 2, retrobulbar neuritis in 1 and sympathetic ophthalmia in 1. Among the 19 samples from 16 patients collected to rule out malignancy, 8 had a confirmed intraocular malignancy. Malignant cells were observed in 5 cases (3 lymphomas, 1 melanoma and 1 carcinoma). Undiagnosed malignancies included 2 lymphomas and 1 choroidal melanoma. Other samples were collected during surgery for retinal detachment and cataracts. Conclusions: In routine practice,cytology of the vitreous fluid is performed in many and varied situationsthat are most often nonneoplastic.In nonneoplastic cases, cytology is a useful adjunct to vitrectomy, in spite of its limitations.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Cytopathology of Vitreous Humor Samples in Routine Practice

Boulagnon-Rombi¹,

Ducasse

Patey³

et al. 2016

Acta Cytologica

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“…Moreover, the finding of free cells (morphologically similar to the hyalocytes) in the posterior chamber is in itself novel and outstanding. To our knowledge, free cells have not been reported to occur inside the posterior chamber, much less the ones known as hyalocytes which are supposed to be confined to the cortical vitreous adjacent to the retina (Balazs et al, 1982 ;Sebag, 1992). The boundaries between the anterior vitreous and the posterior chamber depend much on the topography of the anterior hyaloid membrane.…”

Section: Discussionmentioning

confidence: 93%

“…The work of Balazs and coworkers (Balazs et al, 1964) and comprehensive reviews on the vitreous body (Balazs and Ozanics, 1982 ;Sebag, 1992) show that these cells are located primarily in the cortical vitreous at an average distance of 50 µm from the inner surface of the retina and are concentrated anteriorly in the vitreous base and posteriorly in the vicinities of the optic papilla. Morphological studies using both light and electron microscopy have indicated that the hyalocytes, although smaller, are very similar to macrophages, and, indeed, the most popular concept about their origin proposes that the hyalocytes originate from the blood monocytes (Balazs, Toth and Ozanics, 1980).…”

Section: Introductionmentioning

confidence: 98%

Hyalocyte-Like Cells are more Numerous in the Posterior Chamber than they are in the Vitreous of the Rabbit Eye

Haddad¹,

André²

1998

Experimental Eye Research

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Optical Scattering from Vitreous Floaters

Harmer

Luff²,

Gini

2021

Bioelectromagnetics

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Vitreous “floaters” are a common entoptic phenomenon that can result in significant reduction in quality of life in a proportion of sufferers. The authors use a computational mathematical model based on Fourier optics and reflection and transmission coefficients calculated for a planar type II collagen opacity suspended in aqueous to show that floaters are perceived by the patient through interference effects that result in significant variations in intensity on the retina when viewing a constant brightness surface. The model also predicts that backscattered intensity from floaters is ten thousand to one million times lower than the variations in intensity produced on the retina, which demonstrates that the visible effects of floaters for the patient can be highly significant, whereas clinical observation of the vitreous may be entirely unremarkable. Importantly, the results also demonstrate that floaters do not need to be opaque to cause symptoms, with only small differences in refractive index between the floater material and the surrounding vitreous needed to produce significant optical effects. The model predicts that pupil size is an important factor in determining the severity of symptoms from floaters, with constricted pupils giving much greater effect than dilated pupils. Finally, the authors’ model predicts that floaters degrade contrast sensitivity function, with greatest degradation occurring in the 5–40 cycles per degree spatial frequency range and that the effects of shadowing caused by floaters are very strongly correlated to the predicted degradation of contrast sensitivity function. Bioelectromagnetics. 43:90–105, 2022. © 2021 The Authors. Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society.

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The Vitreous

Cited by 82 publications

References 164 publications

Cytopathology of Vitreous Humor Samples in Routine Practice

Cytopathology of Vitreous Humor Samples in Routine Practice

Hyalocyte-Like Cells are more Numerous in the Posterior Chamber than they are in the Vitreous of the Rabbit Eye

Optical Scattering from Vitreous Floaters

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