Experimental validation of genetic selection for resistance against<i>Streptococcus agalactiae</i>via different routes of infection in the commercial Nile tilapia breeding programme

Joshi, Rajesh; Skaaurd, Anders; Alvarez, Alejandro Tola

doi:10.1111/jbg.12516

Cited by 11 publications

(11 citation statements)

References 17 publications

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“…Here we compared two types of survival definitions; binary traits and continuous traits for our genetic evaluation, with both showing similar heritability estimates ( Table 3 ). While this result did not fit our earlier assumption that continuous traits would improve the results for heritability estimates via adding more survival time information to mortality events, similar findings have been reported for genetic analysis of survival data in experimental challenge tests on aquaculture species (Joshi et al, 2021a; Vu et al, 2021). Binary trait recording however, is much more simple (0, 1) to score than continuous survival data in practice and thus, should be considered more feasible for routine genetic evaluation in aquaculture breeding programs.…”

Section: Discussionsupporting

confidence: 47%

“…This finding agrees with a systematic review paper on c 2 estimation in aquaculture breeding that suggests that full-sib effects contribute only a small proportion of total phenotypic variance at earlier growth stages for growth related traits, but for growth traits in an individual’s later stages or with other phenotypic traits, full-sib effects ( c 2 ) are not significant in most cases and are essentially zero (Nguyen, 2021). As an example routine genetic evaluation models applied in commercial tilapia selection breeding programs based on current published genetic animal models do not include full-sib effects ( c 2 ) (Joshi et al, 2021 b).…”

Section: Discussionmentioning

confidence: 99%

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Insight on Selective Breeding the Robustness Based on Field Survival Records: New Genetic Evaluation of Survival Traits in White-leg Shrimp (Penaeus vannamei) Breeding Line

Ren

Mather

Tang

et al. 2022

Preprint

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Survival is an old trait in animal breeding, yet commonly neglected nowadays for its simple binary records and low levels of heritability in aquaculture species. These traits however, can provide valuable field data when selecting for robustness in genetic improvement programs. In the current study, linear multivariate animal model (LMA) was used for the genetic analysis of survival records from two-year classes (BL2019 and BL2020) of white-leg shrimp (Penaeus vannamei) breeding lines with a total number of 52, 248 individuals from 481 fullsib families recorded for data collection. During grow-out test period, 10 day intervals of survival data were considered as independent traits. Two survival definitions, binary survivability (S) and continuous survival in days (SL), were used for the genetic analysis of survival records to investigate; i) whether adding more survival time information could improve estimation of genetic parameters; ii) the trajectory of survival heritability across time, and iii) patterns of genetic correlations of survival traits across time. Levels of heritability estimates for both S and SL were low (0.005 to 0.076), while heritability for survival day number was found to be similar with that of binary records at each observation time and were highly genetically correlated (rg >0.8). Heritability estimates of body weight (BW) for BL2019 and BL2020 were 0.486 and 0.373, respectively. Trajectories of survival heritability across time showed a gradual increase across the grow-out test period but slowed or reached a plateau during the later grow-out test period. Genetic correlations among survival traits in the grow-out tests were moderate to high, and the closer the times were between estimates, the higher were their genetic correlations. In contrast, genetic correlations between both survival traits and body weight were low but positive. Here we provide the first report of the trajectory of heritability estimates for survival traits across time in aquaculture. Results will be useful for developing robust improved white-leg shrimp culture strains in selective breeding programs based on field survival data.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Insight on Selective Breeding the Robustness Based on Field Survival Records: New Genetic Evaluation of Survival Traits in White-leg Shrimp (Penaeus vannamei) Breeding Line

Ren

Mather

Tang

et al. 2022

Preprint

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“…Using genetics to control disease in aquaculture has become a common practice 14 , which is because breeders were able to reduce the incidence of a major viral disease, infectious pancreatic necrosis (IPN), to near zero in salmon farming via selective breeding 15 . The power of genetics to control Streptococcosis is increasingly being recognised 6 , 7 with various breeding programs incorporating this trait in their selective breeding program 16 and Streptococcus resistant tilapia fingerlings being made available to the farmers 17 .…”

Section: Discussionmentioning

confidence: 99%

“…The development of tilapia strains resistant to Streptococcosis has been proposed as the alternative long-term sustainable strategy to control the disease 6 , 7 . However, the economic analysis to weigh the different strategies for controlling Streptococcosis infection is lacking, with only one such study available for vaccination 8 .…”

Section: Introductionmentioning

confidence: 99%

Economic appraisal of using genetics to control Streptococcus agalactiae in Nile tilapia under cage and pond farming system in Malaysia

Delphino¹,

Joshi²,

Alvarez³

2022

Sci Rep

Self Cite

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Disease outbreaks have been seen as the major threat to sustainable aquaculture worldwide. Injectable vaccines have been one of the few strategies available to control the diseases, however, the adoption of this technology globally is limited. Genetic selection for disease resistance has been proposed as the alternative strategy in livestock and aquaculture. Economic analysis for such strategies is lacking and this study assesses the economic worth of using tilapia fingerlings resistant to Streptococcosis in both cage and pond production systems. The paper also assesses the profitability of paying the higher price for such fingerlings. Partial-budgeting was used to develop a stochastic simulation model that considers the benefits and costs associated with the adoption of tilapia fingerlings resistant to Streptococcosis at the farm level, in one production cycle. In both ponds and cage production systems, the use of genetically selected Streptococcus resistant tilapia fingerlings was found to be profitable where Streptococcus infection is prevalent. In the cages and ponds where Streptococcus related mortality was ≥ 10%, the Nile tilapia aquaculture was found to be profitable even if the amount paid for genetically selected Streptococcus resistant tilapia fingerlings was 100% higher than the amount paid for standard fingerlings.

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“…Fish streptococcosis is a vital disease affecting many species of fish and is characterized by septicemia, meningoencephalitis, and exophthalmia [ 6 ]. S. agalactiae is the most prevalent pathogen among Streptococcus species and causes high morbidity and mortality, and its economic impact on the tilapia industry is greater than 1 billion USD, which has been a hindrance to tilapia farming worldwide [ 1 , 7 , 8 ]. Vaccination prevention and antibiotic treatment are primary measures for reducing tilapia damage caused by S. agalactiae .…”

Section: Introductionmentioning

confidence: 99%

In Vitro Pharmacodynamics and Bactericidal Mechanism of Fungal Defensin-Derived Peptides NZX and P2 against Streptococcus agalactiae

Yang

Mao

et al. 2022

Microorganisms

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(1) Background: Based on the hazard of Streptococcus agalactiae to human and animal health and the increasing drug resistance, it is urgent to develop new antimicrobial agents with high bactericidal activity and low drug resistance against S. agalactiae. This study aims to investigate in vitro pharmacodynamics and bactericidal mechanism of fungal defensin-derived peptides NZX and P2 against S. agalactiae. (2) Methods: Minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) were determined by broth dilution method and AGAR plate dilution method. Cell membrane integrity was determined by flow cytometer. Cell morphological changes were observed by scanning electron microscope (SEM) and transmission electron microscope (TEM). (3) Results: MIC values (NZX: 0.11 μM, P2: 0.91 μM) and MPC (NZX: 1.82 μM) showed their higher antibacterial activity and stronger inhibition ability of drug resistance mutation. The bactericidal mechanism was elucidated that P2 caused S. agalactiae ACCC 61733 cells to deform, bound to the cell wall, and perturbed cell membrane, resulting in K+ leakage, membrane hyperpolarization, ATP release, and reduced cell contents. Compared with P2, NZX focuses on the cell wall, and it bound to the cell wall causing cells boundary disappearance. (4) Conclusion: NZX and P2 are promising antimicrobial agents for streptococcicosis treatment.

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Experimental validation of genetic selection for resistance againstStreptococcus agalactiaevia different routes of infection in the commercial Nile tilapia breeding programme

Cited by 11 publications

References 17 publications

Insight on Selective Breeding the Robustness Based on Field Survival Records: New Genetic Evaluation of Survival Traits in White-leg Shrimp (Penaeus vannamei) Breeding Line

Insight on Selective Breeding the Robustness Based on Field Survival Records: New Genetic Evaluation of Survival Traits in White-leg Shrimp (Penaeus vannamei) Breeding Line

Economic appraisal of using genetics to control Streptococcus agalactiae in Nile tilapia under cage and pond farming system in Malaysia

In Vitro Pharmacodynamics and Bactericidal Mechanism of Fungal Defensin-Derived Peptides NZX and P2 against Streptococcus agalactiae

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