Experimental Urolithiasis. I. Development of Calculi Upon Foreign Bodies Surgically Introduced into Bladders of Rats

Vermeulen, C.W.; Grove, William J.; Goetz, Robert H.; Ragins, Herzl; Correll, N.O.

doi:10.1016/s0022-5347(17)68674-9

Cited by 104 publications

(19 citation statements)

References 4 publications

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“…Vermeulen et al [51] developed a foreign-body model of production of urinary stones. Foreign bodies of a variety of substances were implanted in urinary bladders.…”

Section: Foreign-body Stonesmentioning

confidence: 99%

Animal models of kidney stone formation: an analysis

1997

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Calcific kidney stones in both humans and mildly hyperoxaluric rats are located on renal papillary surfaces and consist of an organic matrix and crystals of calcium oxalate and/or calcium phosphate. The matrix is intimately associated with the crystals and contains substances that can promote as well as inhibit calcification. Osteopontin, Tamm-Horsfall protein, bikunin, and prothrombin fragment 1 have been identified in matrices of both human and rat stones. Hyperoxaluria can provoke calcium oxalate nephrolithiasis in both humans and rats. Kidney-stone-forming rats are hypomagnesuric and hypocitraturic during nephrolithiasis. Human stone formers may have the same disorders. Males of both species are prone to develop calcium oxalate nephrolithiasis, whereas females tend to form calcium phosphate stones. Oxalate metabolism is considered to be almost identical between rats and humans. Thus, there are many similarities between experimental nephrolithiasis induced in rats and human kidney-stone formation, and a rat model of calcium oxalate nephrolithiasis can be used to investigate the mechanisms involved in human kidney stone formation.

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“…Vermeulen et al [51] developed a foreign-body model of production of urinary stones. Foreign bodies of a variety of substances were implanted in urinary bladders.…”

Section: Foreign-body Stonesmentioning

confidence: 99%

Animal models of kidney stone formation: an analysis

1997

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“…The rats were sacrificed, zinc discs along with adhered crystals from the urinary bladders of individual rats were removed, washed in distilled water and were allowed to dry [25,26]. The dried discs were weighed and the difference between the initial and final weights of zinc discs gave the weight of the stone deposited [21].…”

Section: Foreign Body Insertion Techniquementioning

confidence: 99%

A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats

Hwisa¹,

Assaleh²,

Gindi³

et al. 2014

AJPS

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The objective was to investigate the antiurolithiatic activity of aqueous plant extract of Melia azadirachta using the zinc disc implantation model in male Wistar albino rats. A significant increase in urinary excretion of calcium, oxalate, magnesium and phosphate was observed after four weeks of implantation of zinc discs. After treatment with aqueous extract of Melia azadirachta caused a significant reduction (p < 0.001) in stone weight and urinary excretion of electrolytes in both the preventive and curative group of animals as compared to those of control groups. This explains the effect of the aqueous extract of Melia azadirachta in preventing urolithiasis (59%) and dissolving the pre-formed magnesium ammonium phosphate type of stones (46%). The possible mechanism could be due to the urinary stone-formation, lowering, antioxidant, diuretic, nephroprotective constituents present in Melia azadirachta. These results suggest the usefulness of aqueous plant extract of Melia azadirachta as an antiurolithiatic agent.

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“…19 Annual urologic surveillance allows for timely intervention and prevents any long-term complications. Cystoscopic screening examination and subsequent calculi removal done for all three cases establish its utility as an excellent modality for both diagnostic and therapeutic intervention of bladder calculi.…”

Section: -11mentioning

confidence: 99%

Bladder calculi formed over a hair nidus in spinal injury cases

Joshi

Mittal

2013

The Journal of Spinal Cord Medicine

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Clean intermittent catheterization has been demonstrated to be a safe and effective method of bladder drainage in patients with neurogenic bladder dysfunction. However, breakdowns in technique may allow the introduction of foreign matter into the bladder and thereby result in bladder calculi. The three cases reported herein demonstrate this potential problem in persons with spinal cord injury (SCI) with hair nidus as the source of bladder calculi causing neurogenic bladder. In each situation, the problem was identified, calculi were removed cystoscopically and the patient and/or the ancillary aid were reinstructed. We recommend annual renal function tests, ultrasound and cytoscopic screening in high suspicion cases to allow early detection of bladder calculi in persons with SCI and prevent further urinary tract infections. This report also emphasizes the need for patient education and a careful follow-up preventing bladder calculi and thus, minimizing the morbidity in persons with SCI.

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Experimental Urolithiasis. I. Development of Calculi Upon Foreign Bodies Surgically Introduced into Bladders of Rats

Cited by 104 publications

References 4 publications

Animal models of kidney stone formation: an analysis

Animal models of kidney stone formation: an analysis

A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats

Bladder calculi formed over a hair nidus in spinal injury cases

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