Experimental Tympanic Membrane Closure With Collagen Film

Patterson, Mack E.

doi:10.1001/archotol.1967.00760050488005

Cited by 13 publications

(3 citation statements)

References 12 publications

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“…20,21 Collagen, a major extracellular matrix component, also has desirable physical characteristics such as high tensile strength, flexibility, nonreactivity, nontoxicity, and noncarcinogenicity. 7,22 As the main constituent of the lamina propria of the TM, collagen helps in maintaining the resilience and integrity of the TM and, hence, plays a key role in hearing. 23,24 However, only limited studies on silk and collagen as TM scaffolds have been performed, and the hearing outcomes for these scaffold materials have yet to be investigated.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have shown silk fibroin to be cytocompatible, free of toxicity and genotoxity. 44 Collagen has also been known to be nonreactive, nontoxic, and noncarcinogenic 7,22 ; hence, many collagen-based materials have been approved by the Food and Drug Administration (FDA). Since the introduction of Gelfoam in 1945, it has been extensively used in otology mainly as a middle ear packing agent due to its nonantigenicity and nontoxicity.…”

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confidence: 99%

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Scaffolds for Tympanic Membrane Regeneration in Rats

Shen

Redmond

Teh

et al. 2013

Tissue Engineering Part A

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Tympanic membrane (TM) perforations lead to significant hearing loss and result in possible infection of the middle ear. Myringoplasty is commonly performed to repair chronic perforations. Although various grafts and materials have been used to promote TM regeneration, all have associated limitations. The aim of this study was to evaluate the efficacy and feasibility of two graft materials, silk fibroin scaffold (SFS) and porcine-derived acellular collagen type I/III scaffold (ACS), compared with two commonly used graft materials (paper patch and Gelfoam) for the promotion of TM regeneration. These scaffolds were implanted using on-lay myringoplasty in an acute TM perforation rat model. Surface morphology of the scaffolds was observed with scanning electron microscopy. The morphology of the TM was assessed at various time points postimplantation using otoscopy, light and electron microscopy, and functional outcomes by auditory brainstem responses. We found that SFS and ACS significantly accelerated the TM perforation closure, obtained optimal TM thickness, and resulted in better trilaminar morphology with well-organized collagen fibers and early restoration of hearing. However, paper patch and Gelfoam lost their scaffold function in the early stages and showed an inflammatory response, which may have contributed to delayed healing. This study indicates that compared with paper patch and Gelfoam, SFS and ACS are more effective in promoting an early TM regeneration and an improved hearing, suggesting that these scaffolds may be potential substitutes for clinical use.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Scaffolds for Tympanic Membrane Regeneration in Rats

Shen

Redmond

Teh

et al. 2013

Tissue Engineering Part A

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“…A clear-cut middle fibrous layer of connective tissue rich in fibroplasts was evident 2-5 weeks after grafting. Patterson (1967) also tried collagen film reconstituted from bovine Achilles tendon to close eardrum perforations in seven cats (14 ears). Intense inflammatory reaction was incited by the chrome-tanned collagen.…”

Section: Review Of Literaturementioning

confidence: 99%

Pathology as it relates to ear surgery

Belal

1987

J. Laryngol. Otol.

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The surgical anatomy and pathology of the middle ear have been reviewed in relation to tympanoplasty. The results of tympanoplasty in providing a disease-free and functional middle ear varies widely with the pathology involving the eardrum, ossicles, mucoperiosteum, mastoid air cells and eustachian tube. Post-tympanoplasty changes in the eardrum graft, ossicular grafts, and middle ear have been described in six cases which underwent surgery one to eleven years before death. Proper understanding of the pathophysiology of the different diseases of the middle ear is mandatory in planning tympanoplastic procedures. The causes of graft failure and of post-operative conductive hearing loss are discussed and the ways to avoid technical complications are emphasized.

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