A Clinical Study of Human Type IV Collagen as Tympanic Membrane Grafting Material: Preliminary Noncomparative Study

Truy, Éric; Disant, F.; Tiollier, Jérôme; Froehlich, Patrick; Morgon, A

doi:10.1001/archotol.1994.01880360027005

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…Collagen calcium‐alginate films have been used as wound dressing to treat burn patients, demonstrating significant increase in epithelialization, while patients experienced reduced pain levels . Collagen type IV films have been implanted into patients suffering from tympanic pocket retraction and demonstrated complete healing 6 month postimplantation, a potential alternative to autologous tissue . Collagen films have been implanted and assessed after transvesical prostatectomy, exhibiting no adverse reactions .…”

Section: Collagen Scaffoldsmentioning

confidence: 99%

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

et al. 2018

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Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their respective structures, conformation, and biosynthesis is provided. The advances and shortfalls of various collagen preparations (e.g., mammalian/marine extracted collagen, cell‐produced collagens, recombinant collagens, and collagen‐like peptides) and crosslinking technologies (e.g., chemical, physical, and biological) are then critically discussed. Subsequently, an array of structural, thermal, mechanical, biochemical, and biological assays is examined, which are developed to analyze and characterize collagenous structures. Lastly, a comprehensive review is provided on how advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures (e.g., tissue grafts, biomaterials, cell‐assembled tissue equivalents) that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, collagens have a long history in both evolution and biotechnology and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice.

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Section: Collagen Scaffoldsmentioning

confidence: 99%

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

et al. 2018

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“…ACS also achieved similar outcomes as SFS in this study. Although previous studies have shown promising results for collagen membranes for TM reconstruction, 14,31,32 no commonly used scaffolds were used as control materials in these studies, and different animal models were used. AlloDerm, a decellularized extracellular matrix in which the main component is collagen, has recently reported high perforation closure rates (87.5% to 100%).…”

mentioning

confidence: 99%

“…11,45 In this study, the SFS and ACS accelerated and improved TM healing, partly attributed to minimal inflammatory response at the implantation sites, which is consistent with previous reports. 13,32 The biocompatibility of SFS has been established after the removal of sericin, an antigenic glue-like coating protein. 18 We recently showed its biocompatibility and ability to support human TM keratinocyte growth in vitro.…”

mentioning

confidence: 99%

Scaffolds for Tympanic Membrane Regeneration in Rats

Shen

Redmond

Teh

et al. 2013

Tissue Engineering Part A

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Tympanic membrane (TM) perforations lead to significant hearing loss and result in possible infection of the middle ear. Myringoplasty is commonly performed to repair chronic perforations. Although various grafts and materials have been used to promote TM regeneration, all have associated limitations. The aim of this study was to evaluate the efficacy and feasibility of two graft materials, silk fibroin scaffold (SFS) and porcine-derived acellular collagen type I/III scaffold (ACS), compared with two commonly used graft materials (paper patch and Gelfoam) for the promotion of TM regeneration. These scaffolds were implanted using on-lay myringoplasty in an acute TM perforation rat model. Surface morphology of the scaffolds was observed with scanning electron microscopy. The morphology of the TM was assessed at various time points postimplantation using otoscopy, light and electron microscopy, and functional outcomes by auditory brainstem responses. We found that SFS and ACS significantly accelerated the TM perforation closure, obtained optimal TM thickness, and resulted in better trilaminar morphology with well-organized collagen fibers and early restoration of hearing. However, paper patch and Gelfoam lost their scaffold function in the early stages and showed an inflammatory response, which may have contributed to delayed healing. This study indicates that compared with paper patch and Gelfoam, SFS and ACS are more effective in promoting an early TM regeneration and an improved hearing, suggesting that these scaffolds may be potential substitutes for clinical use.

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“…Several other types of grafts have also been used in myringoplasty, including a collagen Type IV film. Its success rate in an uncontrolled study was comparable to that of underlay fascia myringoplasty (21,22). There is evidence, however, that collagen is not a prerequisite for postoperative healing of a chronic perforation of the tympanic membrane because fatty patch myringoplasty has also shown good success rates (23,24).…”

Section: Lamina Propriamentioning

confidence: 86%

Collagen Type Distribution in the Healthy Human Tympanic Membrane

Knutsson¹,

Bagger‐Sjöbäck²,

Unge³

2009

Otology &Amp; Neurotology

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The differences in distribution of collagen types in the different fiber layers of the lamina propria suggest that the lattice of connective tissue supporting the tympanic membrane is not uniform. Understanding the differences in collagen type distribution and in the physical properties of the individual collagen types themselves may contribute to a comprehensive model of retraction pocket pathogenesis.

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A Clinical Study of Human Type IV Collagen as Tympanic Membrane Grafting Material: Preliminary Noncomparative Study

Cited by 10 publications

References 13 publications

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development

Scaffolds for Tympanic Membrane Regeneration in Rats

Collagen Type Distribution in the Healthy Human Tympanic Membrane

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