Collagen Type Distribution in the Healthy Human Tympanic Membrane

Knutsson, Johan; Bagger‐Sjöbäck, Dan; Unge, Magnus von

doi:10.1097/mao.0b013e3181c0e621

Cited by 47 publications

(40 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent histological study demonstrated that a healthy human tympanic membrane consists of collagen type I, II, III and IV. 35 All these collagen types have different mechanical properties. The type I collagen fibers are resistant to force, and type II fibers are resistant to deformation.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Type III provides less strain resistance than Type II. Its role may therefore be mechanoacoustic, promoting the complex vibration patterns of the tympanic membrane that congregate in the umbo velocity [31]. Temporalis fascia consists primarily of collagen type I [32].…”

Section: Discussionmentioning

confidence: 99%

Cartilage–Perichondrium: An Ideal Graft Material?

Chhapola¹,

Matta²

2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Temporalis fascia has long been regarded as the ideal graft material for tympanic membrane repair. However it often does not seem to withstand negative middle ear pressure in the post operative period. Tragal cartilage with perichondrium would appear to be a better graft material with good hearing outcome. It can be obtained easily with cosmetically acceptable incision. In the present study, we have compared the graft properties of temporalis fascia verses tragal cartilage perichondrium with respect to healing, hearing and rate of post operative retraction or reperforation. 132 patients of chronic otitis media with pure conductive hearing loss were posted for tympanoplasty. Temporalis fascia graft was used in 71 patients and cartilage perichondrium (composite graft) was used in 61 patients. Post operative healing, hearing and rate of retraction or reperforation was compared for both the graft materials. All the patients were followed up for 2 years. Patients where temporalis fascia graft was used, 60 (84.5%) showed a good neotympanum, 7(9.85%) had reperforation and 5(7.04%) had retraction pockets. Patients where tragal cartilage perichondrium was used, 60(98.36%) showed a healed tympanic membrane and only 1(1.63%) had reperforation. None of the patients showed retraction pocket or cholestetoma. Postoperative hearing was accessed 6 months after surgery. Patients with temporalis fascia graft showed an air bone gap of less than 10 dB in 49 (82%) patients and more than 10 dB in 11 (18%) patients. Air bone gap closure with tragal cartilage perichondrium was less than 10 dB in 45 (78%) patients and more than 10 dB in 13 patients (22%). Tragal cartilage perichondrium (\0.5 mm) seems to be an ideal graft material for tympanic membrane in terms of postoperative healing and acoustic properties. It can easily withstand negative middle ear pressure which may have contributed to the development of otitis media and significantly affect healing outcomes in postoperative period. Tragal cartilage being composed of collagen type II is also physiologically similar to the nature of the tympanic membrane.

show abstract

“…This might be a reason for the good hearing results after myringoplasty with airbone gaps <30 dB in 90% of the cases, when these materials are used. [18] But they may not withstand negative middle ear pressure in the postoperative period causing retraction and re-perforation. For optimal acoustic transfer behavior, the cartilage should be cut as thin as Springer possible.…”

Section: Methodsmentioning

confidence: 99%

“…He cut the cartilage by a dermatome into plates with thicknesses of 0.2-1 mm. [18] The placement of the cartilage also determines the influence of its stiffness on the acoustic behavior of the reconstructed tympanic membrane. If the cartilage strips or plates are suspended in between the osseous annular rim, the acoustic transfer characteristics of the tympanic membrane are determined by the stiffness.…”

Section: Methodsmentioning

confidence: 99%

Comparative Study of Results of Cartilage-Perichondrium vs Temporalis Fascia Grafting in Active Tubotympanic Type of Chronic Suppurative Otitis Media

Reddy¹

2014

jemds

View full text Add to dashboard Cite

Temporalis fascia has long been regarded as the ideal graft material for tympanic membrane repair. However it often does not seem to withstand negative middle ear pressure in the post-operative period. Tragal cartilage with perichondrium would appear to be a better graft material with good hearing outcome. It can be obtained easily with cosmetically acceptable incision. In the present study, we have compared the graft properties of Temporalis fascia versus Tragal cartilage perichondrium with respect to healing, hearing and rate of postoperative retraction or reperforation. 132 patients of chronic otitis media with pure conductive hearing loss were posted for tympanoplasty. Temporalis fascia graft was used in 71 patients and cartilage perichondrium (composite graft) was used in 61 patients. Post-operative healing, hearing and rate of retraction or re-perforation were compared for both the graft materials. All the patients were followed up for 2 years. Patients where temporalis fascia graft was used, 60 (84.5%) showed a good neotympanum, 7(9.85%) had re-perforation and 5(7.04%) had retraction pockets. Patients where tragal cartilage perichondrium was used, 60(98.36%) showed a healed tympanic membrane and only 1(1.63%) had re-perforation. None of the patients showed retraction pocket or cholestetoma. Postoperative hearing was accessed 6 months after surgery. Patients with temporalis fascia graft showed an air bone gap of less than 10 dB in 49 (82%) patients and more than 10 dB in 11(18%) patients. Air bone gap closure with tragal cartilage perichondrium was less than 10 dB in 45(78%) patients and more than 10 dB in 13 patients (122%). Tragal cartilage perichondrium (<0.5 mm) seems to be an ideal graft material for tympanic membrane in terms of postoperative healing and acoustic properties. It can easily withstand negative middle ear pressure which may have contributed to the development of otitis media and significantly affect healing outcomes in postoperative period. Tragal cartilage being composed of collagen type II is also physiologically similar to the nature of the tympanic membrane.

show abstract

Collagen Type Distribution in the Healthy Human Tympanic Membrane

Cited by 47 publications

References 22 publications

Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis

Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis

Cartilage–Perichondrium: An Ideal Graft Material?

Comparative Study of Results of Cartilage-Perichondrium vs Temporalis Fascia Grafting in Active Tubotympanic Type of Chronic Suppurative Otitis Media

Contact Info

Product

Resources

About