Experimental Tumors of the Nervous System

Mennel, H. D.

doi:10.1007/978-3-642-80786-2_22

Cited by 4 publications

References 19 publications

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Nerve growth factor and neural oncology

Vinores¹,

Perez‐Polo²

1983

J of Neuroscience Research

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The precise role of the nerve growth factor protein (NGF) during the growth and development of the human nervous system is not determined. Although it appears to influence a number of neural functions, its mechanism of action is poorly understood. A number of researchers have proposed that NGF may be involved in several pathological conditions including cancer. It has been shown that NGF is secreted by certain sarcoma (23), neuroblastoma (113), and glioma (7,102,136) cell lines and can bind to neuroblastoma and metastatic melanoma cell lines (42). Neuroblastoma (136,181) and pheochromocytoma (165) cells in vitro can be induced by NGF to differentiate toward a morphologically "more benign" state and appropriate NGF treatment of rats can reduce the number of chemically induced gliomas and neurinomas (174,178). NGF can also reduce the growth of intracerebrally inoculated anaplastic glioma cells (172). Anti-NGF treatment of rats (178) and mice (179) can alter the tumor distribution observed following ethylnitrosourea or benzo(a)pyrene treatment (10). In humans, it has been reported that serum levels of NGF are usually elevated in persons "at risk" for neurofibromatosis (156). The precise nature of the NGF role is not known in these instances. Further understanding of the action of NGF could be of clinical importance.

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Nerve growth factor and neural oncology

Vinores¹,

Perez‐Polo²

1983

J of Neuroscience Research

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Intracranial Tumours of Infancy and Childhood

Zülch¹

1982

Tumours of the Central Nervous System in Infancy and Childhood

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Gross vascularization of experimentally induced transplanted tumors of the central and peripheral nervous system

Pakula

1978

Acta Neuropathol

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Subcutaneously and intracerebrally transplanted neurinomas as well as intracerebrally grafted gliomas, both derived from primary tumors with resorptive carcinogens were investigated after injection of micropaque by conventional histologic methods and by postmortem X-ray analysis. Growth pattern and vasculature were similar in subcutaneously and intracerebrally transplanted malignant neurinomas. The most common feature was a parallel arrangement of vessels as shown by microradiography and vessel free zones. In intracerebrally grafted glioma, the growth of tumors was confined to or starting from the ventricular system. Sinusoidal vessels, capillary proliferations and proliferation of vessel wall were found. The outstanding feature was the occurrence of extravascular contrast deposits, thus indicating the vulnerability of tumor vessels and frequency of hemorrhages into these tumors.

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Experimental Tumors of the Nervous System

Cited by 4 publications

References 19 publications

Nerve growth factor and neural oncology

Nerve growth factor and neural oncology

Intracranial Tumours of Infancy and Childhood

Gross vascularization of experimentally induced transplanted tumors of the central and peripheral nervous system

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