Experimental Transmission of Walleye Dermal Sarcoma to Yellow Perch

Bowser, Paul R.; Wooster, Gregory A.; Getchell, Rodman G.; Paul, Thomas A.; Casey, Rufina N.; Casey, James W.

doi:10.1577/1548-8667(2001)013<0214:etowds>2.0.co;2

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…11 Successful experimental infection trials in sauger (Sander canadensis) and yellow perch expanded the potential host range of this virus. 13,30 Walleye Discrete Epidermal Hyperplasia Discrete epidermal hyperplasia in walleye is a benign seasonal disease that is observed most commonly in spring spawning season on adult fish. Lesions typically regress by late summer.…”

Section: Walleye Dermal Sarcomamentioning

confidence: 99%

“…49 Although experimental transmission efforts have not been successful, the limited amount of tissue and virus concentration made available for the referenced study may have been insufficient to replicate the disease experimentally. 13 …”

Section: Yellow Perch Discrete Epidermal Hyperplasiamentioning

confidence: 99%

“…11 Successful experimental infection trials in sauger ( Sander canadensis ) and yellow perch expanded the potential host range of this virus. 13,30…”

Section: Walleye Dermal Sarcomamentioning

confidence: 99%

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Pathology of Tumors in Fish Associated With Retroviruses

2013

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Thirteen proliferative diseases in fish have been associated in the literature with 1 or more retroviruses. Typically, these occur as seasonal epizootics affecting farmed and wild fish, and most lesions resolve spontaneously. Spontaneous resolution and lifelong resistance to reinfection are 2 features of some piscine retrovirus-induced tumors that have stimulated research interest in this field. The purpose of this review is to present the reader with the epidemiological and morphological features of proliferative diseases in fish that have been associated with retroviruses by 1 or more of the following methods: detection of C-type retroviruslike particles or reverse transcriptase activity in tumor tissues; successful tumor transmission trials using well-characterized, tumor-derived, cell-free inocula; or molecular characterization of the virus from spontaneous and experimentally induced tumors. Two of the diseases included in this review, European smelt spawning papillomatosis and bicolor damselfish neurofibromatosis, at one time were attributed to a retroviral etiology, but both are now believed to involve additional viral agents based on more recent investigations. We include the latter 2 entities to update the reader about these developments. Keywords fishes, piscine, neoplasms, Retroviridae, tumor virus infections, oncogenic virusesMembers of several virus families have been implicated in the etiology of tumors in fish. The literature contains numerous publications in which members of virus families Herpesviridae, Papillomaviridae, and Retroviridae are associated with the development of tumors in fish. In this report, we review the epidemiological, gross, microscopic, and ultrastructural features of 13 piscine tumors reported in the literature for which there is evidence of a retroviral involvement. In some instances, the evidence supporting a retroviral association is compelling and includes viral sequencing and successful transmission trials using a well-characterized inoculum. In other instances, a retroviral association is based on detection of retrovirus-like particles or reverse transcriptase activity in tissues from proliferative lesions. These viruses have been the subject of several reviews. 4,48,49 For this review, we have accessed archival materials primarily from the archived Registry of Tumors in Lower Animals as well as cases from the Aquatic Animal Health Program at the College of Veterinary Medicine, Cornell University.Before evaluating a lesion, any case of a fish tumor must be considered in light of the fish as an ectotherm. Much of the biology of fish is affected by water temperature and seasonality of various physiological processes. It is well known that the immune response in fish is modified by changes in water temperature and other physiological stressors, such as spawning activity. 39 A review of the case records of most fish disease diagnostic laboratories will show the largest number of neoplastic cases to occur in the spring, a time of changing water temperature and a tim...

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Section: Walleye Dermal Sarcomamentioning

confidence: 99%

Section: Yellow Perch Discrete Epidermal Hyperplasiamentioning

confidence: 99%

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Pathology of Tumors in Fish Associated With Retroviruses

2013

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“…Poor transmission of disease was observed with cell-free material from naturally occurring invasive tumors, which likely reflects the low levels of infectious virus present in these tumors [ 24 ]. Dermal sarcoma is also experimentally transmissible to sauger ( Stizostedion canadense) and yellow perch ( Perca flavescens ) [ 29 , 30 ]. Transmission of WEH to walleye fingerlings has also been achieved with cell-free material from lesions collected in the spring [ 17 ].…”

Section: Epsilonretroviruses and Associated Diseasesmentioning

confidence: 99%

Walleye Dermal Sarcoma Virus: Molecular Biology and Oncogenesis

Rovnak

Quackenbush

2010

Viruses

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Retroviruses have been detected in most vertebrate species and are etiologic agents of a variety of neoplastic diseases. The study of retroviruses has been instrumental in uncovering the molecular mechanisms responsible for oncogenesis. Retroviruses have been isolated from three neoplastic diseases in fish, two of which affect the dermis and regress naturally coincident with spawning. This feature provides a unique model to study mechanisms of tumor development and regression. Three complex retroviruses, isolated from walleye (Sander vitreus) with dermal sarcoma and epidermal hyperplasia, are the members of the newest retroviral genus, Epsilonretrovirus. Three accessory proteins, encoded by walleye dermal sarcoma virus (WDSV), function in the regulation of host and viral gene expression and cell cycle, alter cell-signaling pathways to promote cell proliferation and block apoptosis, and, finally, induce apoptosis through dissipation of the mitochondrial membrane potential.

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“…In support of this hypothesis, we have successfully transmitted the virus by waterborne exposure (Bowser, Wooster & Getchell 1999). We have also transmitted walleye dermal sarcoma to young yellow perch in laboratory‐based infection trials through intramuscular injection (Bowser, Wooster, Getchell, Paul, Casey & Casey 2001). However, during the 19 years of our field work, we never have observed walleye dermal sarcoma to affect yellow perch in Oneida Lake.…”

mentioning

confidence: 99%