Experimental transmission of sheep pulmonary adenomatosis (Jaagsiekte)

Wandera, JG

doi:10.1136/vr.83.19.478

Cited by 13 publications

(6 citation statements)

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“…The virus replicates predominantly in the tumour cells (Palmarini and others 1996) and virus is released into the respiratory secretions. Transmission of JSRV occurs mostly through the aerosol route (Dungal and others 1949, Wandera and others 1968), but also via colostrum and milk (Grego and others 2008). …”

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Assessment of transthoracic ultrasound diagnosis of ovine pulmonary adenocarcinoma in adult sheep

Cousens

Scott

2015

Veterinary Record

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Ovine pulmonary adenocarcinoma (OPA), caused by Jaagsiekte sheep retrovirus (JSRV), is a disease of increasing concern in the sheep industry. There is no commercial antemortem test for OPA; therefore, an early evaluation phase study was undertaken to examine the accuracy of transthoracic ultrasound examination using a 5-6.5 MHz sector ultrasound machine widely available in veterinary practice in the UK to diagnose OPA. Restraint, preparation and examination time was restricted to five minutes per sheep to represent the cost limitations of commercial sheep farming. One hundred sheep were examined. All 41 cases identified with suspect OPA lesions during transthoracic ultrasound examination had the diagnosis confirmed at postmortem examination, while sheep without ultrasonographic changes characteristic of OPA had no gross lesions of OPA at postmortem examination. This demonstrates the specificity of transthoracic ultrasound for diagnosis of OPA. The authors propose that, in the absence of any other reliable preclinical diagnostic test, the use of transthoracic ultrasound examination should be considered for a second opinion on an initial diagnosis of OPA, for screening purchased adult flock replacements for OPA, or for screening sheep in a known OPA-affected flock. However, the authors emphasise that a negative scan cannot provide a guarantee that the animal is free of JSRV infection nor early OPA.

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Assessment of transthoracic ultrasound diagnosis of ovine pulmonary adenocarcinoma in adult sheep

Cousens

Scott

2015

Veterinary Record

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“…Depending on country and breed of animal, the incidence varies from less than 1% to as high as 20% (48). Although a number of agents have been implicated in its etiology (45,49), it is now generally accepted that the disease is caused by a retrovirus named the jaagsiekte sheep retrovirus (JSRV) (6,48). Progress in research has been hampered because of the lack of an in vitro culture system.…”

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Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats

York

Vigne

Verwoerd

et al. 1992

J Virol

165

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The complete genome of the jaagsiekte sheep retrovirus (JSRV), the suspected etiological agent of ovine pulmonary carcinoma, has been cloned from viral particles secreted in lung exudates of affected animals and sequenced. The genome is 7,462 nucleotides long and exhibits a genetic organization characteristic of the type B and D oncoviruses. Comparison of the amino acid sequences of JSRV proteins with those of other retrovirus * Corresponding author.

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“…Jaagsiekte (JS), or ovine pulmonary adenomatosis, is a naturally occurring contagious bronchioalveolar adenocarcinoma primarily affecting sheep (4,36,39,43) and, to a lesser extent, goats (30,37). The disease has morphological similarities to human bronchioalveolar carcinoma (19,34).…”

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“…The disease has morphological similarities to human bronchioalveolar carcinoma (19,34). Although a number of agents were implicated in the etiology of JS (36,43), it is now generally accepted that the disease is caused by a retrovirus, the JS retrovirus (JSRV) (4,39). Serological (31), biochemical (5,8,40), and morphological (17) characteristics of JSRV suggest that it is more closely related to the B and D prototype oncoviruses than to the type C retroviruses.…”

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Isolation, identification, and partial cDNA cloning of genomic RNA of jaagsiekte retrovirus, the etiological agent of sheep pulmonary adenomatosis

York

Vigne

Verwoerd

et al. 1991

J Virol

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The genome of the jaagsiekte (JS) retrovirus (JSRV), the etiological agent of sheep pulmonary adenomatosis (jaagsiekte), has been identified, isolated, and partly cloned. The JSRV genome is ca. 8.7 kb long. cDNA of the genomic RNA was synthesized and cloned. A clone, JS 46.1, was isolated and characterized. It has an insert of 2.1 kb which hybridizes to the same 8.7-kb RNA in all the JSRV-infected sheep lung washes tested but does not hybridize to maedi-visna virus, a sheep lentivirus often found coinfecting JSRV-infected lungs. Comparison of the amino acid sequence encoded by JS 46.1 with those encoded by other retroviruses revealed that JSRV has homology to the type D and B oncoviruses and to human endogenous retrovirus.

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Experimental transmission of sheep pulmonary adenomatosis (Jaagsiekte)

Cited by 13 publications

References 0 publications

Assessment of transthoracic ultrasound diagnosis of ovine pulmonary adenocarcinoma in adult sheep

Assessment of transthoracic ultrasound diagnosis of ovine pulmonary adenocarcinoma in adult sheep

Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats

Isolation, identification, and partial cDNA cloning of genomic RNA of jaagsiekte retrovirus, the etiological agent of sheep pulmonary adenomatosis

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