Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats

York, Denis; Vigne, Robert; Verwoerd, Daniel Wynand; Quérat, Gilles

doi:10.1128/jvi.66.8.4930-4939.1992

Cited by 165 publications

(86 citation statements)

References 40 publications

(29 reference statements)

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“…Previous studies also determined a recombinatorial origin for the Type D env [12,38]. However, this conclusion was reached prior to the sequencing of the genome of JSRV [48], which does not possess a gammaretrovirus-like Env, and its subsequent classification as a Type D retrovirus. As such, it was hypothesized that it was this recombination event that gave rise to the Type D lineage of betaretroviruses [12,38].…”

Section: Discussionmentioning

confidence: 98%

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

et al. 2013

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BackgroundBetaretroviruses infect a wide range of species including primates, rodents, ruminants, and marsupials. They exist in both endogenous and exogenous forms and are implicated in animal diseases such as lung cancer in sheep, and in human disease, with members of the human endogenous retrovirus-K (HERV-K) group of endogenous betaretroviruses (βERVs) associated with human cancers and autoimmune diseases. To improve our understanding of betaretroviruses in an evolutionarily distinct host species, we characterized βERVs present in the genomes and transcriptomes of mega- and microbats, which are an important reservoir of emerging viruses.ResultsA diverse range of full-length βERVs were discovered in mega- and microbat genomes and transcriptomes including the first identified intact endogenous retrovirus in a bat. Our analysis revealed that the genus Betaretrovirus can be divided into eight distinct sub-groups with evidence of cross-species transmission. Betaretroviruses are revealed to be a complex retrovirus group, within which one sub-group has evolved from complex to simple genomic organization through the acquisition of an env gene from the genus Gammaretrovirus. Molecular dating suggests that bats have contended with betaretroviral infections for over 30 million years.ConclusionsOur study reveals that a diverse range of betaretroviruses have circulated in bats for most of their evolutionary history, and cluster with extant betaretroviruses of divergent mammalian lineages suggesting that their distribution may be largely unrestricted by host species barriers. The presence of βERVs with the ability to transcribe active viral elements in a major animal reservoir for viral pathogens has potential implications for public health.

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Section: Discussionmentioning

confidence: 98%

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

et al. 2013

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“…The theory of a possible infectious origin of BAC gains support from animal studies. Ovine pulmonary carcinoma (jaagsiekte), probably caused by a retrovirus, resembles BAC morphologically (Geddes, 1987;York et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

p53 protein accumulation and the presence of human papillomavirus dna in bronchiolo‐alveolar carcinoma correlate with poor prognosis

Nuorva

Soini

Kamel

et al. 1995

Intl Journal of Cancer

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Accumulation of the tumour suppressor gene p53 product due to a gene mutation is frequently seen in human carcinomas, including lung carcinoma. Another indirect mechanism involving p53 in malignant growth relates to the E6 protein of the human papillomavirus (HPV), which is able to bind and degrade wild-type p53 protein, thus eliminating its tumour suppressor activities. Bronchiolo-alveolar carcinoma (BAC) is a rare type of lung carcinoma. The aim of our study was to examine the occurrence of p53 accumulation and the presence of HPV DNA in BAC. Sections of 22 BACs were immunohistochemically stained using a p53 antibody, CM-1. The presence of HPV DNA in BACs was verified by in situ hybridisation for HPV types 6, 11, 16, 18, 31 and 33 and confirmed by PCR. Thirty-six percent of the tumours showed abnormal p53 nuclear accumulation, and HPV DNA, revealed by in situ hybridisation, was found in 36%. Unexpectedly, only 13% of the type 1 BACs were positive for p53, whereas 45% of the type 2 BACs were positive. During a follow-up of 12-176 months, only 10% of the patients with BACs negative for both p53 and HPV died of the disease, compared with 42% of the patients with either p53 or HPV positivity. No inverse relationship between abnormal p53 protein accumulation and the presence of HPV DNA was found.

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“…it is important to note that the genome of the ovine pulmonary adenomatosis virus is 7,434 nucleotides long thereby exhibiting a genetic organization of type B as well as D oncoviruses. The enzootic nasal tumor virus is closely related to the Jaagsiekte retrovirus of sheep as well as to sheep endogenous retroviruses [146,147]. Diagnosis of enzootic nasal tumors is based on mainly clinical findings.…”

Section: Enzootic Nasal Tumors and Ovine Pulmonary Adenomatosis (Jaagmentioning

confidence: 99%

Advances in Diagnosis of Respiratory Diseases of Small Ruminants

Chakraborty¹,

Kumar

Tiwari

et al. 2014

Veterinary Medicine International

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Irrespective of aetiology, infectious respiratory diseases of sheep and goats contribute to 5.6 percent of the total diseases of small ruminants. These infectious respiratory disorders are divided into two groups: the diseases of upper respiratory tract, namely, nasal myiasis and enzootic nasal tumors, and diseases of lower respiratory tract, namely, peste des petits ruminants (PPR), parainfluenza, Pasteurellosis, Ovine progressive pneumonia, mycoplasmosis, caprine arthritis encephalitis virus, caseous lymphadenitis, verminous pneumonia, and many others. Depending upon aetiology, many of them are acute and fatal in nature. Early, rapid, and specific diagnosis of such diseases holds great importance to reduce the losses. The advanced enzyme-linked immunosorbent assays (ELISAs) for the detection of antigen as well as antibodies directly from the samples and molecular diagnostic assays along with microsatellites comprehensively assist in diagnosis as well as treatment and epidemiological studies. The present review discusses the advancements made in the diagnosis of common infectious respiratory diseases of sheep and goats. It would update the knowledge and help in adapting and implementing appropriate, timely, and confirmatory diagnostic procedures. Moreover, it would assist in designing appropriate prevention protocols and devising suitable control strategies to overcome respiratory diseases and alleviate the economic losses.

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Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats

Cited by 165 publications

References 40 publications

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

p53 protein accumulation and the presence of human papillomavirus dna in bronchiolo‐alveolar carcinoma correlate with poor prognosis

Advances in Diagnosis of Respiratory Diseases of Small Ruminants

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