Experimental Substantiation of Application of Autoplasma to Reduce Inflammatory Response to Implants in Herniology

Abstract

The article represents an experimental assessment of the effectiveness of the author's method of processing polypropylene mesh implants during their implantation in the tissue of the anterior abdominal wall (Patent of Ukraine No. 146133). It has been demonstrated that the use of the proposed new technology for processing polypropylene mesh implants with a biocompatible component, being a simple, safe, and effective method, optimizes reparative processes in the peri-implantation zone without deteriorating the mechanical properties of mesh implants (MI). All the discovered effects make it possible to increase biocompatibility and improve the survival rate of MI. The thickness of the inflammatory shaft around the elements of MI was significantly decreased, on average, by 28.4% (P<0.05) when using autogenous blood plasma.

Experimental Substantiation of the Use of Xenogenic Cerebrospinal Fluid in Herniology to Reduce the Periprosthetic Reaction

“…Materials of natural origin include embryonic fibroblasts, mesenchymal stem cells, cell-free xenograft, and deproteinized dialysate from calf blood [8,9,10,11,12,13]. The possibility of using xenopericardium [14], amniotic membrane [15], xenoperitoneal extracellular matrix [16], bacterial nanocellulose [17], and autoplasma [18] has been widely studied. Thus, the search for new ways to improve the biocompatibility of MI remains an urgent problem of modern herniology, indicating the relevance of this topic and the need for further research in this area [12,19].…”