Experimental Substantiation of the Use of Xenogenic Cerebrospinal Fluid in Herniology to Reduce the Periprosthetic Reaction

Abstract

The aim of this study was to experimentally validate the possibility and advisability of the treatment of polypropylene mesh implants with xenogenic cerebrospinal fluid in order to reduce a local acute inflammatory response. An experimental evaluation of the effectiveness of the proprietary method of polypropylene mesh implant processing during their implantation in the tissues of the anterior abdominal wall (Patent of Ukraine No. 146637) is presented. It has been proven that the use of the proposed new technology for the treatment of polypropylene mesh implants with a biocompatible component is a simple, safe and effective method that optimizes the reparative processes in the peri-implant zone without affecting the mechanical properties of mesh implants. All of the treatment effects were found to increase the biocompatibility and improve the survival rate of mesh implants. The thickness of the inflammatory ridge around the elements of mesh implants significantly decreased on average by 35.3% when xenogenic cerebrospinal fluid was used.