Experimental subacute spinal cord compression: correlation of serial S100B and NSE serum measurements, histopathological changes, and outcome

Abstract

The initial degree of paresis is not a prognostic factor to predict outcome. Despite timely decompression, pronounced structural lesions of the cord may develop, resulting in an unfavorable outcome. In cases with favorable outcome, sufficient tissue is preserved to maintain function regardless of the initial extent of paresis. This different reaction of the cord may be followed indirectly with serial measurements of S100B serum levels. Thus, S100B is a reliable biochemical marker allowing for prediction of outcome. NSE does not have this prognostic significance.

A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

“…However, although there is a good correlation to spinal cord ischaemia and rises in CSF lactate, there is a lag between its rise and development of CSF lactate [25]. There is now considerable interest with respects to specific biomarkers that can be biochemically analysed and are more sensitive to spinal cord ischaemia than lactate [26][27][28][29][30][31]. In particular, interest has arisen in the area of protein level monitoring, and so the aim of this work is to determine the ability of EM wave sensors to measure varying quantities of protein.…”

The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood

“…the Liaison 184 automatic analyser for S100β and NSE (9,33), but it seems unlikely that the use of automated indicate neuronal damage (34). Of the three NF subunits (i.e.…”

Ex vivo 1H MR spectroscopy and histology after experimental chronic spinal cord compression

“…The assessment, however, was blinded and performed by an expert. However in a previous study using cell counting and Nissl staining, we could show clearly a measurable demise of cells (24). Furthermore we did not quantitatively measure myelin content.…”