Experimental Study on the Lipid Metabolism in the Heart Muscle

Goto, Yuichiro; Hasegawa, Tsuneo; Takitsuka, Hisashi; Kanda, Akinori; Mori, Kosuke; Katayama, Tetsuji; Yoshida, Kentaroh; Nagano, Shiro; Nakamura, Haruo; Hori, Sadaaki; Kato, Masahiro

doi:10.1253/jcj.28.301

Cited by 4 publications

(1 citation statement)

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“…Subsequent A-V studies on nondiabetic humans found that TAG-emulsion accounted for only ~ 17% of cardiac FA uptake; moreover, the heart accounted for only 3% of systemic TAG uptake [2]. Studies in dog heart found that 56% myocardial oxygen consumption (mVO 2 ) was accounted for by total (NEFA+TAG) FA oxidation, of which 71% was calculated to be from TAG (hence about 40% of mVO 2 was TAG oxidation) [3].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The role of triacylglycerol in cardiac energy provision

Evans

Hui‐Kang

2016

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Triacylglycerols (TAG) constitute the main energy storage resource in mammals, by virtue of their high energy density. This in turn is a function of their highly reduced state and hydrophobicity.Limited water solubility, however, imposes specific requirements for delivery and uptake mechanisms on TAG-utilising tissues, including the heart, as well as intracellular disposition. TAGs constitute potentially the major energy supply for working myocardium, both through bloodborne provision and as intracellular TAG within lipid droplets, but also provide the heart with fatty acids (FA) which the myocardium cannot itself synthesise but are required for glycerolipid derivatives with (non-energetic) functions, including membrane phospholipids and lipid signalling molecules. Furthermore they serve to buffer potentially toxic amphipathic fatty acid derivatives.Intracellular handling and disposition of TAGs and their FA and glycerolipid derivatives similarly requires dedicated mechanisms in view of their hydrophobic character. Dysregulation of utilisation can result in inadequate energy provision, accumulation of TAG and/or esterified species, and these may be responsible for significant cardiac dysfunction in a variety of disease states. This review will focus on the role of TAG in myocardial energy provision, by providing FAs from exogenous and endogenous TAG sources for mitochondrial oxidation and ATP production, and how this can change in disease and impact on cardiac function. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 3Key words:heart; triacylglycerol; very-low-density lipoprotein; VLDL; chylomicron; lipid droplet Highlights: Triacylglycerols are supplied to the myocardium within chylomicrons and VLDL  Heart assimilates triacylglycerol-rich lipoproteins by LPL and receptor-mediated routes  Exogenous triacylglycerol-derived fatty acids enter an intracellular lipid pool  Intracardiac triacylglycerol is an important source of fatty acids for oxidation  Dysregulation of triacylglycerol metabolism is associated with cardiac dysfunction

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Section: Accepted Manuscriptmentioning

confidence: 99%