Metabolism of the heart in health and disease. Part III

Opie, Lionel H.

doi:10.1016/0002-8703(69)90197-5

Cited by 156 publications

(37 citation statements)

References 452 publications

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“…The acylation reaction in starved rabbits, in which plasma FFA concentration is higher than in fed animals [2], is similar to the reaction observed in fed rabbits (table 1).…”

Section: Resultssupporting

confidence: 77%

“…Earlier, we observed an increased myocardial TG content following ethanol administration [ 161, which may be explained by the depressed FA oxidation under the condition of the unchanged FA uptake by the heart. A similar mechanism has been proposed for hypoxic hearts [2] .…”

Section: Resultssupporting

confidence: 58%

“…In the hearts of hyperthyroid guinea pigs, however, the myocardial triglyceride (TG) content and FA oxidation were simultaneously increased [4] . This is difficult to explain by evidence presently available, because i) the precursor of cardiac TG, plasma FFA, is increased in the hyperthyroid state [2,3] , and the incorporation of [14C]palmitate or [ 14C] tripalmitin into tissue glycerides can increase by the action of catecholamines [2,6], which may be potentiated by the hormone [3,7] , ii) however, there are results showing that a supply of a second substrate for esterification, glycerophosphate (snglycerol-3-phosphate), is restricted, since the activity of phosphofructokinase, the rate-controlling step of glycolysis, does not increase in hyperthyroidism [8-lo].…”

Section: Introductionmentioning

confidence: 93%

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Acylation of glycerol‐3‐phosphate by rabbit heart mitochondria and microsomes: Triiodothyronine‐induced increase in its activity

Kako¹,

Liu²

1974

FEBS Letters

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“…The acylation reaction in starved rabbits, in which plasma FFA concentration is higher than in fed animals [2], is similar to the reaction observed in fed rabbits (table 1).…”

Section: Resultssupporting

confidence: 77%

Section: Resultssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Acylation of glycerol‐3‐phosphate by rabbit heart mitochondria and microsomes: Triiodothyronine‐induced increase in its activity

Kako¹,

Liu²

1974

FEBS Letters

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“…Except for the unlikely possibility of unidentified reaction(s) from another exogenous substrate, [32][33][34] this discrepancy suggests a marked increase in myocardial utilization of endogenous substrates. Carbohydrate energy reserves in the myocardium are markedly lower than those in skeletal muscle, since the glycogen content of cardiac muscle is about 5 g/kg wet weight, a third to a quarter of that in skeletal muscle.35 In addition, it has been shown that the isolated heart perfused without exogenous substrate cannot maintain contractility for long period of time without failing36 or exhibiting marked endogenous lipid depletion.7 Such a myocardial utilization of endogenous reserves might underlie progressive cardiac depression.…”

Section: Discussionmentioning

confidence: 83%

Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock.

Dhainaut¹,

Huyghebaert²,

Monsallier³

et al. 1987

Circulation

336

122

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To investigate disturbances in the coronary circulation and myocardial metabolism during septic shock, we examined coronary sinus blood flow and myocardial substrate extraction in 40 patients with septic shock and 13 control patients. Patients with coronary artery disease were excluded from this study. The global hemodynamic pattern of the septic patients was characterized by a lower stroke volume, despite an elevated cardiac index. Coronary sinus blood flow was high (187 + 47 vs 130 ± 21 ml/min in the control group, p < .001) due to marked coronary vasodilation, especially in the subgroup of nonsurvivors. In contrast to the control group, myocardial lactate uptake was elevated, while that of free fatty acids, glucose, and ketone bodies was diminished in patients with septic shock. These findings were especially prominent in the nonsurvivors. Expressed as oxygen equivalents, the contribution of free fatty acids as an energy source of the myocardium was markedly diminished in septic patients (12% vs 54% in the control group, p < .005), while that of lactate was increased (36% vs 12%, p < .01). The observed shift in myocardial substrate extraction was associated with a discrepancy between measured myocardial oxygen consumption and that calculated chemically from commonly available exogenous substrates: 41 % of myocardial oxygen consumption was not explained by the utilization of commonly available substrates extracted from coronary circulation in all patients with septic shock. These data indicate that myocardial utilization of endogenous substrates may probably account for this discrepancy, suggesting that a "mandatory" utilization of endogenous energy sources might underlie progressive cardiac involvement in septic shock. Circulation 75, No. 3, 533-541, 1987. SEPTIC SHOCK is a frequent and serious disorder with a high mortality. In recent years, increasing attention has been directed to the study of the hemodynamic and metabolic alterations accompanying septic shock.

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“…Since blood glucose concentration is maintained within a narrow range, glucose is a most reliable substrate for energy production in the heart. The importance of glucose metabolism via glycolysis is well appreciated in ischemic and hypertrophied heart muscle, [1][2][3][4] but aerobic glucose metabolism for support of normal contractile function has received less attention, mainly because of the well-known fact that fatty acids are normally the predominant fuel for cardiac energy production. 2,5,6 We have drawn attention to the heart as a true "omnivore," ie, an organ that functions best when it oxidizes different substrates simultaneously.…”

mentioning

confidence: 99%