Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa

Couto, Eduardo Vieira; Ballin, Carlos Roberto; Sampaio, Cláudia Paraguaçu Pupo; Maeda, Carlos Augusto Seije; Ballin, Carlos Henrique; Dassi, Camila; Miura, Lilian Yukari

doi:10.1016/j.bjorl.2014.12.009

Cited by 5 publications

(7 citation statements)

References 14 publications

(20 reference statements)

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“…86 On the other hand, Kiliç et al (2013) showed general increase in macrophage infiltration on Day 5 post-treatment with glutathione; however, this study lacked quantitative evidence besides H&E staining on the epidermis and lamina propria. 89 Couto et al (2016) studied the effects of applying bismuth subgallate in the buccal wounds of Wistar rat but results found a chronic inflammation status and a possible negative effect leading to delayed healing. 142 Similarly, Ophof et al (2008) stated that treatment with autologous mucosa using de-epidermized dermis or AlloDerm Ò decreased overall degree of inflammation of the experimental wound through semi-quantitative analysis using H&E staining, yet did not support the data with additional quantitative measures.…”

Section: Discussion: Characterizing Oral Wound Healing In Emerging Therapiesmentioning

confidence: 99%

“…89 Couto et al (2016) studied the effects of applying bismuth subgallate in the buccal wounds of Wistar rat but results found a chronic inflammation status and a possible negative effect leading to delayed healing. 142 Similarly, Ophof et al (2008) stated that treatment with autologous mucosa using de-epidermized dermis or AlloDerm Ò decreased overall degree of inflammation of the experimental wound through semi-quantitative analysis using H&E staining, yet did not support the data with additional quantitative measures. 143 Though most studies analyzed inflammatory infiltrates through histological staining, Ballestas et al (2019) additionally included flow cytometric data for quantitative analysis of immune infiltration around the ONF injury in the hard palate.…”

Section: Discussion: Characterizing Oral Wound Healing In Emerging Therapiesmentioning

confidence: 99%

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Oral wound healing models and emerging regenerative therapies

Toma

Fuller

Willett

et al. 2021

Translational Research

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Following injury, the oral mucosa undergoes complex sequences of biological healing processes to restore homeostasis. While general similarities exist, there are marked differences in the genomics and kinetics of wound healing between the oral cavity and cutaneous epithelium. The lack of successful therapy for oral mucosal wounds has influenced clinicians to explore alternative treatments and potential autotherapies to enhance intraoral healing. The present in-depth review discusses current gold standards for oral mucosal wound healing and compares endogenous factors that dictate the quality of tissue remodeling. We conducted a review of the literature on in vivo oral wound healing models and emerging regenerative therapies published during the past twenty years. Studies were evaluated by injury models, therapy interventions, and outcome measures. The success of therapeutic approaches was assessed, and research outcomes were compared based on current hallmarks of oral wound healing. By leveraging therapeutic advancements, particularly within in cell-based biomaterials and immunoregulation, there is great potential for translational therapy in oral tissue regeneration.

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Section: Discussion: Characterizing Oral Wound Healing In Emerging Therapiesmentioning

confidence: 99%

Section: Discussion: Characterizing Oral Wound Healing In Emerging Therapiesmentioning

confidence: 99%

Oral wound healing models and emerging regenerative therapies

Toma

Fuller

Willett

et al. 2021

Translational Research

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“…Microscopically, angiogenesis within the tonsillar fossae commences from pre-existing vessels in the extracellular matrix, facilitating granulation tissue formation 38 . The granulation tissue further proliferates within the tonsillar fossae, often protruding beyond the pillars by day 5 34 , 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Angiogenesis within the tonsillar fossae commences from pre-existing vessels in the extracellular matrix, facilitating the formation of granulation tissue. 38 The granulation tissue further proliferates within the tonsillar fossae, often protruding beyond the pillars by day 5. 34,36 Continued oropharyngeal epithelial ingrowth from the periphery and epithelial contracture results in separation of the fibrinous clot by day 7, exposing the underlying granulation tissue, 34,36 often coinciding with a period of increased risk of secondary hemorrhage.…”

Section: Microscopicmentioning

confidence: 99%

Wound healing after tonsillectomy – a review of the literature

et al. 2018

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ObjectiveTo summarise the available literature related to wound healing post tonsillectomy, including the stages of healing, experimental models for assessing healing (in animals and humans) and the various factors that affect wound healing.MethodsA search of the English literature was conducted using the Ovid Medline database, with the search terms ‘tonsillectomy’ or ‘tonsil’ and ‘wound healing’. Thirty-one articles that objectively assessed tonsillectomy wound healing were included for analysis.ResultsThe majority of assessments in humans investigating tonsillectomy wound healing involve serial direct clinical examinations of the oral cavity. Many patient and surgical factors have been shown to affect wound healing after tonsillectomy. There is some research to suggest that the administration of adjunctive treatment in the post-operative period may be beneficial to tonsillectomy wound healing.ConclusionWound healing post tonsillectomy has been poorly researched. Having a better understanding of the process of wound healing would allow surgeons to potentially prevent, anticipate and manage complications from the surgery that arise as part of the healing process.

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“…Fonte: Autores. Na Tabela 2, apenas o estudo do Couto, et al 2016, relatou uma interação negativa referente a cicatrização após o uso do SB. Portanto, todos os outros estudos mostram que não houve interferência no reparo tecidual e indo de acordo com os estudos clínicos, mostrando que o uso do SB é seguro para hemostasia sem prejudicar no reparo tecidual.…”

Section: Luzzi Et Al (2018)unclassified

Uso do subgalato de bismuto como agente hemostático e sua influência no reparo tecidual em cirurgias odontológicas

Mazzoni¹,

Baldi²,

Roque³

et al. 2021

RSD

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Durante os procedimentos cirúrgicos odontológicos, há o risco de ocorrerem episódios hemorrágicos que podem estar associados a fatores locais e/ou sistêmicos. Um dos materiais que podem ser utilizados como hemostático local é o subgalato de bismuto (SB). O objetivo desse estudo foi avaliar o uso do SB em cirurgias odontológicas, abordando sua eficácia como substância hemostática. Para a revisão de literatura, foram pesquisados artigos nas bases de dados SciELO, PubMed e Scopus, e selecionados artigos pré-clínicos e clínicos que discorressem sobre a influência do subgalato de bismuto em cirurgias odontológicas. O subgalato de bismuto é um metal pesado e insolúvel em água que pode ser utilizado por via oral ou aplicado topicamente. Apresenta eficácia na hemostasia de áreas doadoras palatais, em cirurgias de extrações dentárias e até mesmo em pacientes dialisados. Apesar da sua efetividade como agente hemostático, ele pode provocar alterações no reparo tecidual, como demonstram alguns estudos in vivo na medicina. Esses estudos demonstram efeitos deletérios sobre o reparo tecidual advindos do SB, limitando seu emprego a casos específicos a fim de evitar os riscos de hemorragia trans ou pós-operatória. Já em estudos na área odontológica, tais efeitos não foram observados. Portanto, apesar da literatura demonstrar vantagens no uso do SB como agente hemostático, vale ressaltar que os estudos clínicos em humanos não são numerosos, havendo necessidade de mais pesquisas para verificar sua eficácia clínica e influência sobre o reparo tecidual na busca de protocolos clínicos efetivos.

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Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa

Abstract: Bismuth subgallate had a negative influence on the healing process, delaying the rate of new vessel formation and optimal wound healing.

Cited by 5 publications

References 14 publications

Oral wound healing models and emerging regenerative therapies

Oral wound healing models and emerging regenerative therapies

Wound healing after tonsillectomy – a review of the literature

Uso do subgalato de bismuto como agente hemostático e sua influência no reparo tecidual em cirurgias odontológicas

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