Experimental study on magnesium wire–polylactic acid biodegradable composite implants under in vitro material degradation and fatigue loading conditions

Rizvi, Syed Hasan Askari; Jiale-Che,; Mehboob, Ali; Zaheer, Usama; Chang, Seung‐Hwan

doi:10.1016/j.compstruct.2021.114267

Cited by 14 publications

(7 citation statements)

References 35 publications

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“…Polymer materials that are used in bio-medical applications are cellulose [26], collagen [27], deoxyribonucleic acid [28], polyvinyl chloride (PVC) [24], polypropylene (PP) [29] and polymethyl methacrylate (PMMA) [30]. The properties of polymers such as polylactic acid (PLA) can be tailored for biodegradation with controlled degradation [31].…”

Section: Polymer Based Implantsmentioning

confidence: 99%

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Zwawi

2022

Eng. Res. Express

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Bio-medical implants have increased demand to treat different medical conditions and complications. Latest research in medical and material science is paving the path for new generation of biomedical implants that mimic the natural bone and tissues for enhanced bio compatibility. Bio-medical implant is required to be bio-compatible, non-toxic and bioactive. Main reasons for implantation are aging, overweight, accidents and genetic diseases such as arthritis or joint pain. Diseases such as osteoporosis and osteoarthritis have ability to severely damage the mechanical properties of bones overtime. Different materials including polymers, ceramics and metals are used for biomedical implants. Metallic implants have high strength, high resistance to corrosion and wear. Biocompatible metallic materials include Ti, Ta, Zr, Mo, Nb, W and Au while materials such as Ni, V, Al and Cr are considered as toxic and hazardous to the body. Bioresorbable and degradable materials dissolve in the body after the healing process. Mg based metallic alloys are highly degradable in the biological environment. Similarly, different polymers such as Poly-lactic acid (PLA) are used as bio-degradable implants and in tissue engineering. Biodegradable stents are used in slow release of drugs to avoid the blood clotting and other complications. Shape memory alloys are employed for bio-implants due to unique set of properties. Different surface physical and chemical modification methods are used to improve the interfacial properties and interaction of implant materials with biological environment. This review explains properties, materials, modifications and short comings for bio-implants.

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Section: Polymer Based Implantsmentioning

confidence: 99%

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Zwawi

2022

Eng. Res. Express

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“…These features enable PLA to replace petroleum-based polymers for several Polymers 2021, 13, 3620 2 of 25 biomedical, textile, plastic, 3D printing materials, and packaging applications [14,15]. However, some drawbacks of PLA include its high price and water sensitivity, low crystallinity rate, and fragility [16]. Many researchers aim towards overcoming these limitations, commonly by mixing PLA with natural fibers [17].…”

Section: Introductionmentioning

confidence: 99%

Physical, Mechanical, and Morphological Properties of Treated Sugar Palm/Glass Reinforced Poly(Lactic Acid) Hybrid Composites

et al. 2021

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This research was performed to evaluate the physical, mechanical, and morphological properties of treated sugar palm fiber (SPF)/glass fiber (GF) reinforced poly(lactic acid) (PLA) hybrid composites. Morphological investigations of tensile and flexural fractured samples of composites were conducted with the help of scanning electron microscopy (SEM). Alkaline and benzoyl chloride (BC) treatments of SPFs were performed. A constant weight fraction of 30% total fiber loading and 70% poly(lactic acid) were considered. The composites were initially prepared by a Brabender Plastograph, followed by a hot-pressing machine. The results reported that the best tensile and flexural strengths of 26.3 MPa and 27.3 MPa were recorded after alkaline treatment of SPF, while the highest values of tensile and flexural moduli of 607 MPa and 1847 MPa were recorded after BC treatment of SPF for SPF/GF/PLA hybrid composites. The novel SPF/GF/PLA hybrid composites could be suitable for fabricating automotive components.

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“…[242][243][244][245] It was evident from the studies that the impact-bearing ability, stiffness, compression strength and corrosion resistance were improved when Mg particle (4 wt%) or wire (5% w/w), AZ31 fibers (4 wt%) were reinforced in PLA polymer. [246][247][248][249] Further, techniques to counterbalance and control the corrosion were to treat Mg alloy with microarc-oxidation (MAO) or doped in stearic acid or coating with Mg(OH) 2 , MgF 2 , MgO. [250][251][252][253][254][255][256] These methods significantly improved the interfacial adhesion of Mg alloy by providing micro-anchoring action with PLA, leading to better degradation performance, mechanical strength and cell viability.…”

Section: Magnesium Microparticlesmentioning

confidence: 99%

“…It was evident from the studies that the impact‐bearing ability, stiffness, compression strength and corrosion resistance were improved when Mg particle (4 wt%) or wire (5% w/w), AZ31 fibers (4 wt%) were reinforced in PLA polymer 246‐249 …”

Section: Pla‐bioresorbable Metal Biocompositementioning

confidence: 99%

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

Srivastava,

Bhati,

Singh

et al. 2024

Polymer Engineering & Sci

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Poly(lactic acid) (PLA) is one of the most promising biopolymers extensively used in food, packaging, medical and pharmaceutical industries. It is due to favorable physicochemical properties, in‐situ hydrolytic degradation and well‐established processing parameters. However, in medical engineering applications, PLA shows some drawbacks like low cell adhesion, biological inertness, slow degradation rate and high acid inflammation. These shortcomings of pure PLA could be addressed by blending it with other bioresorbable materials and compatibilizers. This review provides comprehensive information on different PLA composites in the field of tissue engineering, implants, injury management and drug delivery systems. The PLA‐based composites are divided into four parts: PLA/polymer, PLA/metal, PLA/ceramic, and PLA/nanoparticles. It also investigates various synthesis process, role of different compatibilizers, in vitro studies and their in vivo applications.Highlights Review the trends of bioresorbable PLA blends/composites. Extensively focused on PLA blend with polymer, metal, ceramic, and nanoparticles. Role of reinforcement and compatibilizer to overcome shortcomings of PLA implant. Highlights advantages, limitations, and properties of different types of PLA implants. Discuss various clinical applications and future of PLA blends/composite scaffolds.

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Experimental study on magnesium wire–polylactic acid biodegradable composite implants under in vitro material degradation and fatigue loading conditions

Cited by 14 publications

References 35 publications

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Recent advances in bio-medical implants; mechanical properties, surface modifications and applications

Physical, Mechanical, and Morphological Properties of Treated Sugar Palm/Glass Reinforced Poly(Lactic Acid) Hybrid Composites

A review on polylactic acid‐based blends/composites and the role of compatibilizers in biomedical engineering applications

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